PL2968249T3 - Gamma-diketony jako aktywatory szlaku sygnałowego Wnt/beta-kateniny - Google Patents

Gamma-diketony jako aktywatory szlaku sygnałowego Wnt/beta-kateniny

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Publication number
PL2968249T3
PL2968249T3 PL14753569T PL14753569T PL2968249T3 PL 2968249 T3 PL2968249 T3 PL 2968249T3 PL 14753569 T PL14753569 T PL 14753569T PL 14753569 T PL14753569 T PL 14753569T PL 2968249 T3 PL2968249 T3 PL 2968249T3
Authority
PL
Poland
Prior art keywords
diketones
wnt
gamma
beta
signaling pathway
Prior art date
Application number
PL14753569T
Other languages
English (en)
Inventor
Sunil Kumar Kc
David Mark Wallace
John Hood
Charlene Barroga
Original Assignee
Samumed, Llc
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Publication date
Application filed by Samumed, Llc filed Critical Samumed, Llc
Publication of PL2968249T3 publication Critical patent/PL2968249T3/pl

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
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    • C07D411/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
PL14753569T 2013-02-22 2014-02-21 Gamma-diketony jako aktywatory szlaku sygnałowego Wnt/beta-kateniny PL2968249T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361768033P 2013-02-22 2013-02-22
EP14753569.4A EP2968249B1 (en) 2013-02-22 2014-02-21 Gamma-diketones as wnt/beta -catenin signaling pathway activators
PCT/US2014/017794 WO2014130869A1 (en) 2013-02-22 2014-02-21 Gamma-diketones as wnt/beta -catenin signaling pathway activators

Publications (1)

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PL2968249T3 true PL2968249T3 (pl) 2019-06-28

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US (5) US9533976B2 (pl)
EP (2) EP2968249B1 (pl)
JP (2) JP6401189B2 (pl)
KR (1) KR102252567B1 (pl)
CN (1) CN105188696A (pl)
AU (2) AU2014218720B2 (pl)
BR (1) BR112015020391B1 (pl)
CA (1) CA2901671C (pl)
CL (2) CL2015002363A1 (pl)
CY (1) CY1122751T1 (pl)
DK (1) DK2968249T3 (pl)
ES (1) ES2709824T3 (pl)
HK (1) HK1214953A1 (pl)
HR (1) HRP20190142T1 (pl)
HU (1) HUE042001T2 (pl)
IL (1) IL240628B (pl)
LT (1) LT2968249T (pl)
MA (1) MA38421A1 (pl)
ME (1) ME03296B (pl)
MX (1) MX368663B (pl)
MY (1) MY176004A (pl)
PE (1) PE20151721A1 (pl)
PH (1) PH12015501847A1 (pl)
PL (1) PL2968249T3 (pl)
PT (1) PT2968249T (pl)
RS (1) RS58432B1 (pl)
RU (2) RU2680716C2 (pl)
SG (2) SG10201606032VA (pl)
SI (1) SI2968249T1 (pl)
TR (1) TR201901496T4 (pl)
WO (1) WO2014130869A1 (pl)
ZA (1) ZA201506438B (pl)

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ES2835553T3 (es) 2009-08-10 2021-06-22 Biosplice Therapeutics Inc Inhibidores de indazol de la vía de señalización de Wnt y sus usos terapéuticos
RS62051B1 (sr) 2010-08-18 2021-07-30 Biosplice Therapeutics Inc Diketoni i hidroksiketoni kao aktivatori katenin signalnog puta
TR201901496T4 (tr) 2013-02-22 2019-02-21 Samumed Llc Wnt/Beta -katenin sinyal yolağı aktivatörleri olarak gamma-diketonları.
ES2762559T3 (es) 2014-08-20 2020-05-25 Samumed Llc Gamma-dicetonas para tratamiento y prevención de envejecimiento de la piel y arrugas
CN104311544A (zh) * 2014-09-22 2015-01-28 湖南华腾制药有限公司 一种苯并恶唑衍生物的制备方法
CN104292179A (zh) * 2014-10-19 2015-01-21 湖南华腾制药有限公司 一种2-氯苯并[d]恶唑-5-甲醛的制备方法
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CN109678687B (zh) * 2018-12-11 2022-02-11 沾化大荣化工科技有限公司 一种邻羟基苯乙酮类化合物的高效制备方法
CA3136920A1 (en) * 2019-06-06 2020-12-10 Fermenta Biotech Limited An improved process to synthesize 5-(3-pyridyl)-2,2'-bithiophene(sensitizer)
CN111632147A (zh) * 2020-06-07 2020-09-08 重庆医科大学 骨细胞Wnt激活剂在制备骨折加速愈合、防治骨不连及不运动或失重骨丢失药物中的应用
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