PL2173751T3 - Metabolity inhibitora kinazy Janusowej (R)-3-(4-(7H-pirolo[2,3-d]pirymidyn-4- ylo)-1H-pirazol-1-ilo)-3-cyklopentylopropanonitrylu - Google Patents

Metabolity inhibitora kinazy Janusowej (R)-3-(4-(7H-pirolo[2,3-d]pirymidyn-4- ylo)-1H-pirazol-1-ilo)-3-cyklopentylopropanonitrylu

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Publication number
PL2173751T3
PL2173751T3 PL08770791T PL08770791T PL2173751T3 PL 2173751 T3 PL2173751 T3 PL 2173751T3 PL 08770791 T PL08770791 T PL 08770791T PL 08770791 T PL08770791 T PL 08770791T PL 2173751 T3 PL2173751 T3 PL 2173751T3
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PL
Poland
Prior art keywords
cyclopentylpropanenitrile
pyrrolo
pyrazol
pyrimidin
metabolites
Prior art date
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PL08770791T
Other languages
English (en)
Polish (pl)
Inventor
James D Rodgers
Argyrios G Arvanitis
Jack Guoen Shi
Original Assignee
Incyte Corp
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Publication date
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Publication of PL2173751T3 publication Critical patent/PL2173751T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
PL08770791T 2007-06-13 2008-06-12 Metabolity inhibitora kinazy Janusowej (R)-3-(4-(7H-pirolo[2,3-d]pirymidyn-4- ylo)-1H-pirazol-1-ilo)-3-cyklopentylopropanonitrylu PL2173751T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94369507P 2007-06-13 2007-06-13
PCT/US2008/066658 WO2008157207A2 (en) 2007-06-13 2008-06-12 Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3- cyclopentylpropanenitrile
EP08770791.5A EP2173751B1 (en) 2007-06-13 2008-06-12 Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3- cyclopentylpropanenitrile

Publications (1)

Publication Number Publication Date
PL2173751T3 true PL2173751T3 (pl) 2014-04-30

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PL08770791T PL2173751T3 (pl) 2007-06-13 2008-06-12 Metabolity inhibitora kinazy Janusowej (R)-3-(4-(7H-pirolo[2,3-d]pirymidyn-4- ylo)-1H-pirazol-1-ilo)-3-cyklopentylopropanonitrylu

Country Status (25)

Country Link
US (5) US7834022B2 (enExample)
EP (1) EP2173751B1 (enExample)
JP (1) JP5479331B2 (enExample)
KR (1) KR20100049008A (enExample)
CN (1) CN101815717B (enExample)
AR (1) AR067024A1 (enExample)
AU (1) AU2008266182B8 (enExample)
BR (1) BRPI0812563A2 (enExample)
CA (1) CA2689158C (enExample)
CL (1) CL2008001709A1 (enExample)
CO (1) CO6251255A2 (enExample)
CR (1) CR11149A (enExample)
EA (1) EA017790B1 (enExample)
EC (1) ECSP099821A (enExample)
ES (1) ES2448868T3 (enExample)
GE (1) GEP20125534B (enExample)
IL (1) IL202429A0 (enExample)
MX (2) MX339139B (enExample)
NZ (1) NZ581801A (enExample)
PL (1) PL2173751T3 (enExample)
PT (1) PT2173751E (enExample)
TW (1) TWI426911B (enExample)
UA (1) UA99465C2 (enExample)
WO (1) WO2008157207A2 (enExample)
ZA (1) ZA200908820B (enExample)

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