PL204759B1 - Sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w komórkach eukariotycznych oraz sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w zarodkowych komórkach macierzystych myszy - Google Patents

Sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w komórkach eukariotycznych oraz sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w zarodkowych komórkach macierzystych myszy

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Publication number
PL204759B1
PL204759B1 PL361927A PL36192701A PL204759B1 PL 204759 B1 PL204759 B1 PL 204759B1 PL 361927 A PL361927 A PL 361927A PL 36192701 A PL36192701 A PL 36192701A PL 204759 B1 PL204759 B1 PL 204759B1
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Poland
Prior art keywords
gene
chromosomal locus
cells
endogenous gene
ltvec
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PL361927A
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English (en)
Polish (pl)
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PL361927A1 (en
Inventor
Aris N. Economides
Andrew J. Murphy
David M. Valenzuela
David Frendewey
George D. Yancopoulos
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Regeneron Pharma
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Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of PL361927A1 publication Critical patent/PL361927A1/xx
Publication of PL204759B1 publication Critical patent/PL204759B1/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL361927A 2000-10-31 2001-10-31 Sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w komórkach eukariotycznych oraz sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w zarodkowych komórkach macierzystych myszy PL204759B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24466500P 2000-10-31 2000-10-31
US09/732,234 US6586251B2 (en) 2000-10-31 2000-12-07 Methods of modifying eukaryotic cells

Publications (2)

Publication Number Publication Date
PL361927A1 PL361927A1 (en) 2004-10-04
PL204759B1 true PL204759B1 (pl) 2010-02-26

Family

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PL361927A PL204759B1 (pl) 2000-10-31 2001-10-31 Sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w komórkach eukariotycznych oraz sposób genetycznego modyfikowania endogennego genu lub lokus chromosomalnego w zarodkowych komórkach macierzystych myszy

Country Status (18)

Country Link
US (1) US6586251B2 (OSRAM)
EP (1) EP1399575B1 (OSRAM)
JP (7) JP5339566B2 (OSRAM)
KR (1) KR100833136B1 (OSRAM)
CN (1) CN100497642C (OSRAM)
AT (1) ATE332388T1 (OSRAM)
AU (2) AU2002220048B2 (OSRAM)
BR (1) BRPI0115096B1 (OSRAM)
CA (1) CA2426398C (OSRAM)
CZ (1) CZ304856B6 (OSRAM)
DE (1) DE60121372T2 (OSRAM)
HU (1) HU227639B1 (OSRAM)
MX (1) MXPA03003797A (OSRAM)
NO (1) NO332300B1 (OSRAM)
NZ (1) NZ525511A (OSRAM)
PL (1) PL204759B1 (OSRAM)
RU (1) RU2290441C2 (OSRAM)
WO (1) WO2002036789A2 (OSRAM)

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