PL176091B1 - Pochodne 5-aryloindolu - Google Patents

Pochodne 5-aryloindolu

Info

Publication number
PL176091B1
PL176091B1 PL93308669A PL30866993A PL176091B1 PL 176091 B1 PL176091 B1 PL 176091B1 PL 93308669 A PL93308669 A PL 93308669A PL 30866993 A PL30866993 A PL 30866993A PL 176091 B1 PL176091 B1 PL 176091B1
Authority
PL
Poland
Prior art keywords
indol
ylmethyl
benzimidazole
cyano
compound
Prior art date
Application number
PL93308669A
Other languages
English (en)
Polish (pl)
Other versions
PL308669A1 (en
Inventor
John E. Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PL308669A1 publication Critical patent/PL308669A1/xx
Publication of PL176091B1 publication Critical patent/PL176091B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
PL93308669A 1992-11-02 1995-05-01 Pochodne 5-aryloindolu PL176091B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
PCT/US1993/009790 WO1994010171A1 (en) 1992-11-02 1993-10-19 5-arylindole derivatives and their use as serotonin (5-ht1) agonists

Publications (2)

Publication Number Publication Date
PL308669A1 PL308669A1 (en) 1995-08-21
PL176091B1 true PL176091B1 (pl) 1999-04-30

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
PL93308669A PL176091B1 (pl) 1992-11-02 1995-05-01 Pochodne 5-aryloindolu

Country Status (27)

Country Link
US (1) US5886008A (en:Method)
EP (2) EP0666858B1 (en:Method)
JP (1) JP2788551B2 (en:Method)
KR (1) KR0163371B1 (en:Method)
CN (1) CN1051313C (en:Method)
AT (1) ATE202102T1 (en:Method)
AU (1) AU685066B2 (en:Method)
BR (1) BR9307348A (en:Method)
CA (2) CA2148380C (en:Method)
CZ (1) CZ283001B6 (en:Method)
DE (1) DE69330351T2 (en:Method)
DK (1) DK0666858T3 (en:Method)
EG (1) EG20396A (en:Method)
ES (1) ES2157224T3 (en:Method)
FI (2) FI111257B (en:Method)
GR (1) GR3036579T3 (en:Method)
HU (1) HU222235B1 (en:Method)
IL (1) IL107386A (en:Method)
MY (1) MY109696A (en:Method)
NO (1) NO309652B1 (en:Method)
NZ (1) NZ257059A (en:Method)
PL (1) PL176091B1 (en:Method)
PT (1) PT666858E (en:Method)
RU (1) RU2134266C1 (en:Method)
TW (1) TW251284B (en:Method)
WO (1) WO1994010171A1 (en:Method)
ZA (1) ZA938137B (en:Method)

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BR9810508A (pt) 1997-07-03 2000-09-05 Du Pont Pharm Co Composto, composição farmacêutica e método de tratamento de uma desordem
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6353008B1 (en) * 1998-06-30 2002-03-05 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
AU2003284981B2 (en) 2002-10-30 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
WO2004096130A2 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
AU2004268950A1 (en) * 2003-08-21 2005-03-10 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine-derivatives as c-kit inhibitors
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
SG149828A1 (en) 2003-10-03 2009-02-27 3M Innovative Properties Co Alkoxy substituted imidazoquinolines
KR101130928B1 (ko) 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 치환된 이미다조 고리 시스템 및 방법
DE102004014304A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
ES2346157T3 (es) * 2006-03-22 2010-10-11 Janssen Pharmaceutica N.V. Derivados de alquilaminas ciclicas como inhibidores de la interaccion entre mdm2 y p53.
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
US11312712B2 (en) 2015-04-29 2022-04-26 Janssen Pharmaceutica Nv Azabenzimidazoles and their use as AMPA receptor modulators
AU2016255431B2 (en) 2015-04-29 2020-05-07 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators
CN107635970B (zh) 2015-04-29 2021-03-12 詹森药业有限公司 苯并咪唑酮和苯并噻唑酮化合物以及它们作为ampa受体调节剂的用途
BR112017023200A2 (pt) 2015-04-29 2018-08-07 Janssen Pharmaceutica Nv compostos de indolona e seu uso como moduladores do receptor de ampa
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
JP6839184B2 (ja) 2015-11-06 2021-03-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ インドリン−２−オン誘導体
CN108349942B (zh) 2015-11-06 2021-03-30 豪夫迈·罗氏有限公司 用于治疗cns和相关疾病的二氢吲哚-2-酮衍生物
JP6857651B2 (ja) 2015-11-06 2021-04-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ疾患の処置に有用なインドリン−２−オン誘導体
CR20180255A (es) 2015-11-06 2018-06-22 Hoffmann La Roche Derivados de indolin-2-ona
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法

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Also Published As

Publication number Publication date
ATE202102T1 (de) 2001-06-15
CZ283001B6 (cs) 1997-12-17
DK0666858T3 (da) 2001-08-27
PT666858E (pt) 2001-09-28
HU222235B1 (hu) 2003-05-28
RU2134266C1 (ru) 1999-08-10
FI111257B (fi) 2003-06-30
IL107386A0 (en) 1994-01-25
FI934825A0 (fi) 1993-11-01
NO309652B1 (no) 2001-03-05
AU5329494A (en) 1994-05-24
FI934825L (fi) 1994-05-03
IL107386A (en) 1999-03-12
CA2148380C (en) 2001-08-14
MY109696A (en) 1997-04-30
NZ257059A (en) 1997-07-27
CN1051313C (zh) 2000-04-12
CA2148380A1 (en) 1994-05-11
CN1094727A (zh) 1994-11-09
EP0666858B1 (en) 2001-06-13
KR950704313A (ko) 1995-11-17
GR3036579T3 (en) 2001-12-31
US5886008A (en) 1999-03-23
FI20002505L (fi) 2000-11-15
WO1994010171A1 (en) 1994-05-11
NO951633D0 (no) 1995-04-28
FI20002505A7 (fi) 2000-11-15
CA2340999C (en) 2005-01-04
ES2157224T3 (es) 2001-08-16
DE69330351D1 (de) 2001-07-19
ZA938137B (en) 1995-05-02
DE69330351T2 (de) 2001-09-20
PL308669A1 (en) 1995-08-21
RU95109927A (ru) 1997-01-10
CZ110895A3 (en) 1995-11-15
KR0163371B1 (ko) 1998-12-01
AU685066B2 (en) 1998-01-15
CA2340999A1 (en) 1994-05-11
EP0666858A1 (en) 1995-08-16
BR9307348A (pt) 1999-05-11
JP2788551B2 (ja) 1998-08-20
EG20396A (en) 1999-02-28
HUT66011A (en) 1994-08-29
NO951633L (no) 1995-04-28
EP1094064A1 (en) 2001-04-25
JPH07508759A (ja) 1995-09-28
TW251284B (en:Method) 1995-07-11

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