PL146201B1 - Method of obtaining 3 betha-/n-benzyl-n-methylamino/-ethyl-5-methyl 2,6-dimethyl-4-/3'-nitrophenyl/-1,4-dihydropyridinodicarboxylate-3,5 and its chlorhydride - Google Patents
Method of obtaining 3 betha-/n-benzyl-n-methylamino/-ethyl-5-methyl 2,6-dimethyl-4-/3'-nitrophenyl/-1,4-dihydropyridinodicarboxylate-3,5 and its chlorhydride Download PDFInfo
- Publication number
- PL146201B1 PL146201B1 PL1986259577A PL25957786A PL146201B1 PL 146201 B1 PL146201 B1 PL 146201B1 PL 1986259577 A PL1986259577 A PL 1986259577A PL 25957786 A PL25957786 A PL 25957786A PL 146201 B1 PL146201 B1 PL 146201B1
- Authority
- PL
- Poland
- Prior art keywords
- dimethyl
- nitrophenyl
- benzyl
- temperature
- dihydropyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU847/85A YU43409B (en) | 1985-05-21 | 1985-05-21 | Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL146201B1 true PL146201B1 (en) | 1989-01-31 |
Family
ID=25551689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1986259577A PL146201B1 (en) | 1985-05-21 | 1986-05-20 | Method of obtaining 3 betha-/n-benzyl-n-methylamino/-ethyl-5-methyl 2,6-dimethyl-4-/3'-nitrophenyl/-1,4-dihydropyridinodicarboxylate-3,5 and its chlorhydride |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4769465A (en, 2012) |
| EP (1) | EP0202625B1 (en, 2012) |
| JP (1) | JPS6341459A (en, 2012) |
| AT (1) | ATE55122T1 (en, 2012) |
| DD (1) | DD247217A5 (en, 2012) |
| DE (1) | DE3673064D1 (en, 2012) |
| DK (2) | DK233686A (en, 2012) |
| FI (1) | FI83641C (en, 2012) |
| PL (1) | PL146201B1 (en, 2012) |
| SI (1) | SI8510847A8 (en, 2012) |
| SU (2) | SU1419516A3 (en, 2012) |
| YU (1) | YU43409B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3833893A1 (de) * | 1988-10-05 | 1990-04-12 | Bayer Ag | Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte |
| DE4041814A1 (de) * | 1990-12-24 | 1992-07-02 | Byk Gulden Lomberg Chem Fab | Verfahren zur herstellung von dihydrophyridincarbonsaeuren |
| JP3286645B2 (ja) * | 1993-03-26 | 2002-05-27 | メルシャン株式会社 | 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法 |
| US7585978B2 (en) * | 2006-11-28 | 2009-09-08 | Navinta Llc | Processes of manufacturing substituted-1,4-dihydropyridines, improved aqueous solutions thereof, and processes of manufacturing the solutions |
| ES2332168B1 (es) * | 2008-04-30 | 2010-10-27 | Consejo Superior De Investigaciones Cientificas (Csic) (75%) | Forma pseudopolimorfica de hidrocloruro de nicardipina, procedimiento para su preparacion y formulacion que la contiene. |
| CN113072483A (zh) * | 2021-03-30 | 2021-07-06 | 济南良福精合医药科技有限公司 | 盐酸尼卡地平的精制方法 |
| CN119613324A (zh) * | 2025-02-17 | 2025-03-14 | 广州市桐晖药业有限公司 | 一种盐酸尼卡地平的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2218644C3 (de) * | 1972-04-18 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| US3974275A (en) * | 1972-04-18 | 1976-08-10 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives |
| US3996234A (en) * | 1972-04-18 | 1976-12-07 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
| JPS5930704B2 (ja) * | 1973-02-20 | 1984-07-28 | 山之内製薬株式会社 | 新規１，４−ジヒドロピリジン誘導体の製法 |
| US4285955A (en) * | 1978-10-31 | 1981-08-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridinecarboxylic acids |
| DE2847237A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Verfahren zur herstellung von 1,4-dihydropyridincarbonsaeuren sowie ihre verwendung als arzneimittel |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4483985A (en) * | 1978-10-31 | 1984-11-20 | Bayer Aktiengesellschaft | Production of 1,4-dihydropyridinecarboxylic acids |
| JPS59137461A (ja) * | 1983-01-27 | 1984-08-07 | Kyowa Hakko Kogyo Co Ltd | １，４−ジヒドロピリジン誘導体 |
| ZA848907B (en) * | 1983-11-16 | 1985-06-26 | Ciba Geigy Ag | Novel amide compounds |
| US4672068A (en) * | 1984-05-04 | 1987-06-09 | Fujirebio Kabushiki Kaisha | Antihypertensive 1,4-dihydropyridines having a conjugated ester |
| JPS6124567A (ja) * | 1984-07-13 | 1986-02-03 | Taisho Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
| JPS6124568A (ja) * | 1984-07-13 | 1986-02-03 | Taisho Pharmaceut Co Ltd | ジヒドロピリジンエステルの製造法 |
-
0
- DK DK8602336D patent/DK8602336A/da unknown
-
1985
- 1985-05-21 SI SI8510847A patent/SI8510847A8/sl unknown
- 1985-05-21 YU YU847/85A patent/YU43409B/xx unknown
-
1986
- 1986-05-14 US US06/862,938 patent/US4769465A/en not_active Expired - Fee Related
- 1986-05-16 AT AT86106700T patent/ATE55122T1/de not_active IP Right Cessation
- 1986-05-16 DE DE8686106700T patent/DE3673064D1/de not_active Expired - Lifetime
- 1986-05-16 EP EP86106700A patent/EP0202625B1/de not_active Expired - Lifetime
- 1986-05-20 DK DK233686A patent/DK233686A/da not_active Application Discontinuation
- 1986-05-20 PL PL1986259577A patent/PL146201B1/pl unknown
- 1986-05-20 FI FI862111A patent/FI83641C/fi not_active IP Right Cessation
- 1986-05-20 SU SU864027513A patent/SU1419516A3/ru active
- 1986-05-20 DD DD86290391A patent/DD247217A5/de not_active IP Right Cessation
- 1986-08-01 JP JP61180258A patent/JPS6341459A/ja active Granted
-
1987
- 1987-04-10 SU SU874202339A patent/SU1493104A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU1419516A3 (ru) | 1988-08-23 |
| DD247217A5 (de) | 1987-07-01 |
| ATE55122T1 (de) | 1990-08-15 |
| DK233686D0 (da) | 1986-05-20 |
| FI83641B (fi) | 1991-04-30 |
| JPH0521105B2 (en, 2012) | 1993-03-23 |
| EP0202625A3 (en) | 1987-07-01 |
| JPS6341459A (ja) | 1988-02-22 |
| FI862111A0 (fi) | 1986-05-20 |
| US4769465A (en) | 1988-09-06 |
| YU43409B (en) | 1989-06-30 |
| DK233686A (da) | 1986-11-22 |
| FI83641C (fi) | 1991-08-12 |
| EP0202625B1 (de) | 1990-08-01 |
| DE3673064D1 (de) | 1990-09-06 |
| SI8510847A8 (en) | 1996-04-30 |
| FI862111A7 (fi) | 1986-11-22 |
| SU1493104A3 (ru) | 1989-07-07 |
| EP0202625A2 (de) | 1986-11-26 |
| DK8602336A (en, 2012) | 1986-11-22 |
| YU84785A (en) | 1987-12-31 |
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