YU43409B - Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate - Google Patents

Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate

Info

Publication number
YU43409B
YU43409B YU847/85A YU84785A YU43409B YU 43409 B YU43409 B YU 43409B YU 847/85 A YU847/85 A YU 847/85A YU 84785 A YU84785 A YU 84785A YU 43409 B YU43409 B YU 43409B
Authority
YU
Yugoslavia
Prior art keywords
dimethyl
nitrophenyl
temperature
dihydropyridine
methyl
Prior art date
Application number
YU847/85A
Other languages
English (en)
Other versions
YU84785A (en
Inventor
Antoncic Lj
Lj Antoncic
I Jezbec
D Kocjan
I Krivec
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK8602336D priority Critical patent/DK8602336A/da
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Priority to SI8510847A priority patent/SI8510847A8/sl
Priority to YU847/85A priority patent/YU43409B/xx
Priority to US06/862,938 priority patent/US4769465A/en
Priority to AT86106700T priority patent/ATE55122T1/de
Priority to DE8686106700T priority patent/DE3673064D1/de
Priority to EP86106700A priority patent/EP0202625B1/de
Priority to DK233686A priority patent/DK233686A/da
Priority to FI862111A priority patent/FI83641C/fi
Priority to DD86290391A priority patent/DD247217A5/de
Priority to SU864027513A priority patent/SU1419516A3/ru
Priority to PL1986259577A priority patent/PL146201B1/pl
Priority to JP61180258A priority patent/JPS6341459A/ja
Priority to SU874202339A priority patent/SU1493104A3/ru
Publication of YU84785A publication Critical patent/YU84785A/xx
Publication of YU43409B publication Critical patent/YU43409B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
YU847/85A 1985-05-21 1985-05-21 Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate YU43409B (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DK8602336D DK8602336A (xx) 1985-05-21
SI8510847A SI8510847A8 (en) 1985-05-21 1985-05-21 Process for preparation of 2-(n-benzyl-n-methylamino)-ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and its hydrochloride salts
YU847/85A YU43409B (en) 1985-05-21 1985-05-21 Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate
US06/862,938 US4769465A (en) 1985-05-21 1986-05-14 Process for the preparation of 2-(N-benzyl-N-methylamino)-ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and its hydrochloride salt
AT86106700T ATE55122T1 (de) 1985-05-21 1986-05-16 Verfahren zur herstellung von 2,6-dimethyl-4-(3'nitrophenyl)-1,4-dihydropyridin-3,5-dicarbonsaeu e-3 beta-(n-benzyl-n-methylamino)-ethylester-5methylester und dessen hydrochlorid-salz.
DE8686106700T DE3673064D1 (de) 1985-05-21 1986-05-16 Verfahren zur herstellung von 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarbonsaeure-3 beta-(n-benzyl-n-methylamino)-ethylester-5-methylester und dessen hydrochlorid-salz.
EP86106700A EP0202625B1 (de) 1985-05-21 1986-05-16 Verfahren zur Herstellung von 2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarbonsäure-3 beta-(N-benzyl-N-methylamino)-ethylester-5-methylester und dessen Hydrochlorid-Salz
DK233686A DK233686A (da) 1985-05-21 1986-05-20 Fremgangsmaade til fremstilling af 2-(n-benzyl-n-methylamino)-ethylmethyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydro-pyridin-3,5-dicarboxylat eller hydrochloridet deraf
FI862111A FI83641C (fi) 1985-05-21 1986-05-20 Foerfarande foer framstaellning av 2(n-bensyl-n-metylamino)-etylmetyl-2,6-dimetyl-4-(m-nitrofenyl) -1,4-dihydropyridin-3,5-dikarboxylat och dess hydrokloridsalt.
DD86290391A DD247217A5 (de) 1985-05-21 1986-05-20 Verfahren zur herstellung von 2,6,-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarbonsaeure-3 beta (n-benzyl-n-methylamino)-ethylester-5-methylester und dessen hydrochlorid-salz
SU864027513A SU1419516A3 (ru) 1985-05-21 1986-05-20 Способ получени 5-метилового 3 @ -(N-бензил-N-метиламино)-этилового эфира 2,6-диметил-4-(3 @ -нитрофенил)-1,4-дигидропиридин-3,5-дикарбоновой кислоты или его сол нокислой соли
PL1986259577A PL146201B1 (en) 1985-05-21 1986-05-20 Method of obtaining 3 betha-/n-benzyl-n-methylamino/-ethyl-5-methyl 2,6-dimethyl-4-/3'-nitrophenyl/-1,4-dihydropyridinodicarboxylate-3,5 and its chlorhydride
JP61180258A JPS6341459A (ja) 1985-05-21 1986-08-01 ２−（Ｎ−ベンジル−Ｎ−メチルアミノ）−エチルメチル２，６−ジメチル−４−（ｍ−ニトロフエニル）−１，４−ジヒドロピリジン−３，５−ジカルボキシレ−ト及びその塩酸塩の製造法
SU874202339A SU1493104A3 (ru) 1985-05-21 1987-04-10 Способ получени 5-метилового-3 @ -(N-бензил-N-метиламино)-этилового эфира 2,6-диметил-4-(3Ъ-нитрофенил)-1,4-дигидропиридин-3,5-дикарбоновой кислоты или его сол нокислой соли

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU847/85A YU43409B (en) 1985-05-21 1985-05-21 Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate

Publications (2)

Publication Number Publication Date
YU84785A YU84785A (en) 1987-12-31
YU43409B true YU43409B (en) 1989-06-30

Family

ID=25551689

Family Applications (1)

Application Number Title Priority Date Filing Date
YU847/85A YU43409B (en) 1985-05-21 1985-05-21 Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate

Country Status (12)

Country Link
US (1) US4769465A (xx)
EP (1) EP0202625B1 (xx)
JP (1) JPS6341459A (xx)
AT (1) ATE55122T1 (xx)
DD (1) DD247217A5 (xx)
DE (1) DE3673064D1 (xx)
DK (2) DK233686A (xx)
FI (1) FI83641C (xx)
PL (1) PL146201B1 (xx)
SI (1) SI8510847A8 (xx)
SU (2) SU1419516A3 (xx)
YU (1) YU43409B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3833893A1 (de) * 1988-10-05 1990-04-12 Bayer Ag Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte
DE4041814A1 (de) * 1990-12-24 1992-07-02 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von dihydrophyridincarbonsaeuren
JP3286645B2 (ja) * 1993-03-26 2002-05-27 メルシャン株式会社 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
US7585978B2 (en) * 2006-11-28 2009-09-08 Navinta Llc Processes of manufacturing substituted-1,4-dihydropyridines, improved aqueous solutions thereof, and processes of manufacturing the solutions
ES2332168B1 (es) * 2008-04-30 2010-10-27 Consejo Superior De Investigaciones Cientificas (Csic) (75%) Forma pseudopolimorfica de hidrocloruro de nicardipina, procedimiento para su preparacion y formulacion que la contiene.
CN113072483A (zh) * 2021-03-30 2021-07-06 济南良福精合医药科技有限公司 盐酸尼卡地平的精制方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3974275A (en) * 1972-04-18 1976-08-10 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives
US3996234A (en) * 1972-04-18 1976-12-07 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5930704B2 (ja) * 1973-02-20 1984-07-28 山之内製薬株式会社 新規１，４−ジヒドロピリジン誘導体の製法
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4483985A (en) * 1978-10-31 1984-11-20 Bayer Aktiengesellschaft Production of 1,4-dihydropyridinecarboxylic acids
DE2847237A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Verfahren zur herstellung von 1,4-dihydropyridincarbonsaeuren sowie ihre verwendung als arzneimittel
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
JPS59137461A (ja) * 1983-01-27 1984-08-07 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
ZA848907B (en) * 1983-11-16 1985-06-26 Ciba Geigy Ag Novel amide compounds
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
JPS6124567A (ja) * 1984-07-13 1986-02-03 Taisho Pharmaceut Co Ltd ジヒドロピリジン誘導体
JPS6124568A (ja) * 1984-07-13 1986-02-03 Taisho Pharmaceut Co Ltd ジヒドロピリジンエステルの製造法

Also Published As

Publication number Publication date
DD247217A5 (de) 1987-07-01
US4769465A (en) 1988-09-06
JPS6341459A (ja) 1988-02-22
SU1493104A3 (ru) 1989-07-07
YU84785A (en) 1987-12-31
DK233686A (da) 1986-11-22
EP0202625B1 (de) 1990-08-01
EP0202625A3 (en) 1987-07-01
EP0202625A2 (de) 1986-11-26
ATE55122T1 (de) 1990-08-15
FI862111A (fi) 1986-11-22
DE3673064D1 (de) 1990-09-06
SI8510847A8 (en) 1996-04-30
FI83641C (fi) 1991-08-12
DK8602336A (xx) 1986-11-22
JPH0521105B2 (xx) 1993-03-23
FI862111A0 (fi) 1986-05-20
FI83641B (fi) 1991-04-30
PL146201B1 (en) 1989-01-31
DK233686D0 (da) 1986-05-20
SU1419516A3 (ru) 1988-08-23

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