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Teijin Ltd
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Teijin Ltd
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Priority to JP19366787ApriorityCriticalpatent/JPS6438067A/en
Publication of JPS6438067ApublicationCriticalpatent/JPS6438067A/en
NEW MATERIAL:The 1,4-dihydropyridine derivative labeled with deuterium and expressed by formula I [X, Y and Z are halogen, nitro or H provided these are not H at the same time; R<1> and R<2> are (deuterium-substituted) methyl; R<3> is (deuterium-substituted) benzyl; at least one of R<1>-R<3> is deuterium- substituted methyl or benzyl] or its acid addition salt. EXAMPLE:2,6-Dimethyl-4-(2-fluoro-5-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarbox ylic acid methyl-3-(N-[<2>H7]benzyl-N-methylamino)-2,2-dimethylpropyl ester. USE:Internal standard for the microanalysis of 1,4-dihydropyridine drug for circula tory system. PREPARATION:For example, the compound of formula II is converted to the corresponding acetoacetic acid derivative and the R<1> of the product is labeled with deuterium by modified Hantzsch reaction.
JP19366787A1987-08-041987-08-041,4-dihydropyridine derivative labeled with deuterium
PendingJPS6438067A
(en)
Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties
Process for preparing certain 1-lower alkanoyl or benzoyl-4-(lower alkanoyl or benzoyl-methylidene)-1,4-dihydropyridines or acid addition salts thereof
Process for the preparation of new 20,21-dinor-eburnamenine derivatives, new intermediates thereof, as well as pharmaceutical compositions containing said compounds as active ingredients
New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it
SUBSTITUTED ALKYLAMINO DERIVATIVES OF 6,11DIHYDRO-11-OXO-DIBENZ(B,E)-OXEPIN, PROCESSES FOR THEIR PREPARATION, THEIR INTERMEDIATE PRODUCTS AND THEIR USE AS MEDICINAL PRODUCTS.