ES2091183T3 - Metodo para mejorar el sueño. - Google Patents

Metodo para mejorar el sueño.

Info

Publication number
ES2091183T3
ES2091183T3 ES88200587T ES88200587T ES2091183T3 ES 2091183 T3 ES2091183 T3 ES 2091183T3 ES 88200587 T ES88200587 T ES 88200587T ES 88200587 T ES88200587 T ES 88200587T ES 2091183 T3 ES2091183 T3 ES 2091183T3
Authority
ES
Spain
Prior art keywords
6alkyl
aminocarbonyl
optionally substituted
hydroxyc1
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88200587T
Other languages
English (en)
Inventor
Daele Georges Henri Paul Van
Freddy Francois Vlaeminck
Marc Gustaaf Celine Verdonck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2091183T3 publication Critical patent/ES2091183T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE EL USO, PARA LA FABRICACION DE UN MEDICAMENTO PARA MEJORAR EL SUEÑO Y TRATAR DESORDENES DEL SUEÑO DE UN DERIVADO DE PIPERAZINA DE FORMULA (I) DONDE R1, R2, AR Y Q TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA INVENCION COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS ULTIMOS COMPUESTOS OCMO INGREDIENTES ACTIVOS Y METODOS DE PREPARACION DE DICHOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS.
ES88200587T 1987-04-01 1988-03-29 Metodo para mejorar el sueño. Expired - Lifetime ES2091183T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3412987A 1987-04-01 1987-04-01

Publications (1)

Publication Number Publication Date
ES2091183T3 true ES2091183T3 (es) 1996-11-01

Family

ID=21874492

Family Applications (2)

Application Number Title Priority Date Filing Date
ES88200587T Expired - Lifetime ES2091183T3 (es) 1987-04-01 1988-03-29 Metodo para mejorar el sueño.
ES96200236T Expired - Lifetime ES2167510T3 (es) 1987-04-01 1988-03-29 Agentes para mejorar el sueño.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES96200236T Expired - Lifetime ES2167510T3 (es) 1987-04-01 1988-03-29 Agentes para mejorar el sueño.

Country Status (21)

Country Link
EP (2) EP0285219B1 (es)
JP (1) JP2574377B2 (es)
KR (1) KR960016539B1 (es)
AT (2) ATE142627T1 (es)
AU (1) AU609790B2 (es)
CA (1) CA1315790C (es)
DE (2) DE3856501T2 (es)
DK (1) DK174878B1 (es)
ES (2) ES2091183T3 (es)
FI (1) FI97617C (es)
GR (1) GR3020983T3 (es)
HK (1) HK1006020A1 (es)
HU (2) HUT57740A (es)
IE (1) IE81057B1 (es)
IL (1) IL85919A (es)
NO (1) NO178660C (es)
NZ (1) NZ223847A (es)
PH (1) PH25507A (es)
PT (1) PT87118B (es)
RU (1) RU2014328C1 (es)
ZA (1) ZA882352B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
JP2574585B2 (ja) * 1989-11-22 1997-01-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 再潅流損傷の防止又は制限のための薬剤
JP2660086B2 (ja) * 1990-07-03 1997-10-08 明治製菓株式会社 脳及び心機能障害改善剤
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
EP0582164B1 (en) * 1992-07-31 1998-12-23 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
PT756593E (pt) * 1994-04-20 2001-01-31 Lonza Ag Processo para a producao de derivados de acido 2-piperazinocarboxilico
CA2234342A1 (en) * 1997-04-10 1998-10-10 Kyowa Hakko Kogyo Co., Ltd. Pancreatitis remedy
EP0999840B1 (en) 1997-06-16 2003-05-02 Janssen Pharmaceutica N.V. Use of a draflazine analogue for treating pain
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
CA2596393C (en) 2004-12-30 2014-09-23 Janssen Pharmaceutica N.V. 4-(benzyl)-piperazine-1-carboxylic acid phenylamide derivatives and related compounds as modulators of fatty acid amide hydrolase for the treatment of anxiety, pain and other conditions
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN110511220B (zh) * 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Also Published As

Publication number Publication date
AU1384788A (en) 1988-10-06
EP0727421B1 (en) 2001-10-24
DK179788D0 (da) 1988-03-30
NO178660B (no) 1996-01-29
FI97617B (fi) 1996-10-15
NO178660C (no) 1996-05-08
KR960016539B1 (ko) 1996-12-14
PH25507A (en) 1991-07-24
HU211129A9 (en) 1995-10-30
PT87118A (pt) 1988-04-01
JP2574377B2 (ja) 1997-01-22
DK179788A (da) 1988-10-02
GR3020983T3 (en) 1996-12-31
FI97617C (fi) 1997-01-27
ES2167510T3 (es) 2002-05-16
ATE207474T1 (de) 2001-11-15
DE3855520D1 (de) 1996-10-17
HK1006020A1 (en) 1999-02-05
EP0727421A1 (en) 1996-08-21
NO881407L (no) 1988-10-03
JPS63290869A (ja) 1988-11-28
NO881407D0 (no) 1988-03-29
CA1315790C (en) 1993-04-06
DK174878B1 (da) 2004-01-12
DE3856501D1 (de) 2001-11-29
EP0285219A2 (en) 1988-10-05
DE3855520T2 (de) 1997-02-06
EP0285219A3 (en) 1991-07-03
PT87118B (pt) 1992-07-31
IE81057B1 (en) 1999-12-29
KR880012566A (ko) 1988-11-28
ZA882352B (en) 1989-12-27
IL85919A0 (en) 1988-09-30
NZ223847A (en) 1989-12-21
IE880989L (en) 1988-10-01
ATE142627T1 (de) 1996-09-15
HUT57740A (en) 1991-12-30
AU609790B2 (en) 1991-05-09
FI881525A (fi) 1988-10-02
FI881525A0 (fi) 1988-03-31
DE3856501T2 (de) 2004-04-29
EP0285219B1 (en) 1996-09-11
IL85919A (en) 1992-12-01
RU2014328C1 (ru) 1994-06-15

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