PT87163A - Process for preparing 1-phenyl-3-naphthalenyloxipropanamines - Google Patents
Process for preparing 1-phenyl-3-naphthalenyloxipropanaminesInfo
- Publication number
- PT87163A PT87163A PT87163A PT8716388A PT87163A PT 87163 A PT87163 A PT 87163A PT 87163 A PT87163 A PT 87163A PT 8716388 A PT8716388 A PT 8716388A PT 87163 A PT87163 A PT 87163A
- Authority
- PT
- Portugal
- Prior art keywords
- phenyl
- hydrogen
- naphthalenyloxipropanamines
- preparing
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3653487A | 1987-04-09 | 1987-04-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT87163A true PT87163A (pt) | 1988-05-01 |
| PT87163B PT87163B (pt) | 1992-07-31 |
Family
ID=21889125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87163A PT87163B (pt) | 1987-04-09 | 1988-04-06 | Processo para a preparacao de 1-fenil-3-naftaleniloxi-propanaminas |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0288188B1 (pt) |
| JP (1) | JPH0637443B2 (pt) |
| KR (1) | KR960007723B1 (pt) |
| CN (1) | CN1020093C (pt) |
| AT (1) | ATE68473T1 (pt) |
| AU (1) | AU602971B2 (pt) |
| CA (1) | CA1329937C (pt) |
| CY (1) | CY1658A (pt) |
| DE (1) | DE3865504D1 (pt) |
| DK (1) | DK170637B1 (pt) |
| EG (1) | EG18584A (pt) |
| ES (1) | ES2045109T3 (pt) |
| GR (1) | GR3003267T3 (pt) |
| HK (1) | HK63992A (pt) |
| HU (1) | HU204767B (pt) |
| IL (1) | IL85988A (pt) |
| MX (1) | MX11031A (pt) |
| NZ (1) | NZ224161A (pt) |
| PH (1) | PH27141A (pt) |
| PT (1) | PT87163B (pt) |
| SG (1) | SG67092G (pt) |
| SU (1) | SU1568886A3 (pt) |
| ZA (1) | ZA882418B (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK258389D0 (da) * | 1989-05-26 | 1989-05-26 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
| ZA921292B (en) * | 1991-02-25 | 1993-08-23 | Lilly Co Eli | Treatment of lower urinary tract disorders. |
| WO1993013049A1 (fr) * | 1991-12-20 | 1993-07-08 | Karin Elisabeth Peuschel | Emploi de l'effet immunoactivant de 3-naphthyloxy-2-hydroxy-propylamines, interessant specialement pour l'immunite cellulaire, par exemple contre infections virales |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| PT778263E (pt) * | 1994-08-22 | 2002-06-28 | Mitsubishi Pharma Corp | Composto de benzeno e sua utilizacao farmaceutica |
| DE19956786A1 (de) * | 1999-11-25 | 2001-05-31 | Basf Ag | Verfahren zur Herstellung optisch aktiver Amine |
| CN100402488C (zh) * | 2006-03-15 | 2008-07-16 | 上海玛耀化学技术有限公司 | 一种达泊西汀的合成方法 |
| WO2008035358A2 (en) * | 2006-06-05 | 2008-03-27 | Cadila Healthcare Limited | Process for preparing dapoxetine |
| CN101367739B (zh) * | 2008-09-24 | 2013-02-13 | 台州职业技术学院 | N,n-二甲基-1-苯基-3-(1-萘氧基)丙胺制备工艺 |
| DE102009015702A1 (de) | 2009-03-31 | 2010-10-07 | Ratiopharm Gmbh | Tabletten enthaltend Dapoxetin und Trockenverarbeitungsverfahren zu deren Herstellung |
| WO2011058572A2 (en) | 2009-11-13 | 2011-05-19 | Symed Labs Limited | Solid dapoxetine |
| DE102009058321A1 (de) | 2009-12-15 | 2011-06-16 | Ratiopharm Gmbh | Schmelztablette, enthaltend Dapoxetin |
| WO2011161690A1 (en) * | 2010-06-23 | 2011-12-29 | Symed Labs Limited | Processes for the preparation of (+)-n,n-dimethyl-2-[1-(naphthalenyloxy) ethyl] benzene methanamine and intermediates thereof |
| CN102229538B (zh) * | 2011-05-11 | 2013-11-13 | 中南大学 | 一种达泊西汀的合成方法 |
| CN102850318A (zh) * | 2011-07-01 | 2013-01-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的选择性5-羟色胺重摄取抑制剂及其医药用途 |
| CN103130660B (zh) * | 2011-11-25 | 2014-09-17 | 厦门福满药业有限公司 | 一类达泊西汀的酸式盐及其晶体,以及晶体的制备方法 |
| WO2013180675A1 (en) | 2012-05-28 | 2013-12-05 | Mahmut Bilgic | Tablet formulation comprising dapoxetine |
| CN102746170A (zh) * | 2012-07-28 | 2012-10-24 | 湖南尔文生物科技有限公司 | 一种达泊西汀的制备方法 |
| WO2014027982A2 (en) | 2012-08-17 | 2014-02-20 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Novel effervescent sachet formulations of dapoxetine and a pde5 inhibitor |
| US20150202168A1 (en) | 2012-08-17 | 2015-07-23 | Sanovel llac Sanayi Ve Ticaret Anonim Sirketi | Oral film formulations comprising dapoxetine and tadalafil |
| US20150216798A1 (en) | 2012-08-17 | 2015-08-06 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Novel orally administered pharmaceutical formulations |
| US20150320677A1 (en) | 2012-08-17 | 2015-11-12 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Effervescent tablet formulations of dapoxetine and a pde5 inhibitor |
| TR201309037A2 (tr) | 2012-08-17 | 2014-03-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dapoksetin ve bir pde5 inhibitörü içeren yeni efervesan saşe formülasyonları. |
| WO2014027979A2 (en) | 2012-08-17 | 2014-02-20 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Tablet formulations comprising tadalafil and dapoxetine |
| CN102942496B (zh) * | 2012-11-28 | 2014-06-11 | 扬州工业职业技术学院 | (s)-n,n-二甲基-3-(萘酚-1-氧基)-1-苯基丙基-1-胺的制备方法 |
| EP2749553A1 (en) | 2012-12-31 | 2014-07-02 | Deva Holding Anonim Sirketi | Process for preparation of enantiomerically pure S-(+)-N, N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine |
| CN106748825A (zh) * | 2016-11-29 | 2017-05-31 | 聊城大学 | 一种达泊西汀的合成、拆分纯化和成盐方法 |
| CN108853072A (zh) * | 2018-08-03 | 2018-11-23 | 安徽省金楠医疗科技有限公司 | 一种盐酸达泊西汀片及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018895A (en) * | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| US4207343A (en) * | 1978-06-22 | 1980-06-10 | Eli Lilly And Company | 1-Phenyl-3-(substituted phenoxy)propylamines |
| NZ213651A (en) * | 1984-10-11 | 1989-07-27 | Hoffmann La Roche | Tetrahydronapthalene derivatives and medicaments |
-
1988
- 1988-04-06 IL IL85988A patent/IL85988A/xx not_active IP Right Cessation
- 1988-04-06 PT PT87163A patent/PT87163B/pt not_active IP Right Cessation
- 1988-04-06 CA CA000563374A patent/CA1329937C/en not_active Expired - Fee Related
- 1988-04-07 PH PH36759A patent/PH27141A/en unknown
- 1988-04-07 DK DK188288A patent/DK170637B1/da not_active IP Right Cessation
- 1988-04-07 ZA ZA882418A patent/ZA882418B/xx unknown
- 1988-04-07 AU AU14335/88A patent/AU602971B2/en not_active Ceased
- 1988-04-07 JP JP63088025A patent/JPH0637443B2/ja not_active Expired - Lifetime
- 1988-04-07 NZ NZ224161A patent/NZ224161A/en unknown
- 1988-04-07 EG EG19888A patent/EG18584A/xx active
- 1988-04-07 MX MX1103188A patent/MX11031A/es unknown
- 1988-04-08 HU HU881790A patent/HU204767B/hu not_active IP Right Cessation
- 1988-04-08 ES ES88303177T patent/ES2045109T3/es not_active Expired - Lifetime
- 1988-04-08 DE DE8888303177T patent/DE3865504D1/de not_active Expired - Lifetime
- 1988-04-08 CN CN88102018A patent/CN1020093C/zh not_active Expired - Fee Related
- 1988-04-08 EP EP88303177A patent/EP0288188B1/en not_active Expired - Lifetime
- 1988-04-08 SU SU884355511A patent/SU1568886A3/ru active
- 1988-04-08 KR KR1019880003954A patent/KR960007723B1/ko not_active IP Right Cessation
- 1988-04-08 AT AT88303177T patent/ATE68473T1/de not_active IP Right Cessation
-
1991
- 1991-12-04 GR GR91401895T patent/GR3003267T3/el unknown
-
1992
- 1992-07-01 SG SG670/92A patent/SG67092G/en unknown
- 1992-08-20 HK HK639/92A patent/HK63992A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1658A patent/CY1658A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG67092G (en) | 1992-09-04 |
| KR880012526A (ko) | 1988-11-28 |
| EP0288188B1 (en) | 1991-10-16 |
| ZA882418B (en) | 1989-12-27 |
| DE3865504D1 (de) | 1991-11-21 |
| KR960007723B1 (ko) | 1996-06-11 |
| AU602971B2 (en) | 1990-11-01 |
| AU1433588A (en) | 1988-10-13 |
| IL85988A (en) | 1992-08-18 |
| JPH0637443B2 (ja) | 1994-05-18 |
| GR3003267T3 (en) | 1993-02-17 |
| HUT50316A (en) | 1990-01-29 |
| DK188288D0 (da) | 1988-04-07 |
| DK188288A (da) | 1989-01-12 |
| MX11031A (es) | 1993-11-01 |
| DK170637B1 (da) | 1995-11-20 |
| EG18584A (en) | 1994-07-30 |
| CY1658A (en) | 1993-05-14 |
| SU1568886A3 (ru) | 1990-05-30 |
| PT87163B (pt) | 1992-07-31 |
| CN88102018A (zh) | 1988-10-26 |
| HU204767B (en) | 1992-02-28 |
| EP0288188A1 (en) | 1988-10-26 |
| ES2045109T3 (es) | 1994-01-16 |
| CA1329937C (en) | 1994-05-31 |
| IL85988A0 (en) | 1988-09-30 |
| ATE68473T1 (de) | 1991-11-15 |
| PH27141A (en) | 1993-04-02 |
| CN1020093C (zh) | 1993-03-17 |
| HK63992A (en) | 1992-08-28 |
| JPS63258837A (ja) | 1988-10-26 |
| NZ224161A (en) | 1990-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19920128 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19980731 |