DK8602336A - - Google Patents
Info
- Publication number
- DK8602336A DK8602336A DK8602336DA DK8602336A DK 8602336 A DK8602336 A DK 8602336A DK 8602336D A DK8602336D A DK 8602336DA DK 8602336 A DK8602336 A DK 8602336A
- Authority
- DK
- Denmark
- Prior art keywords
- dimethyl
- temperature
- dihydropyridine
- nitrophenyl
- benzyl
- Prior art date
Links
- 239000003960 organic solvent Substances 0.000 abstract 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 2
- WOUANPHGFPAJCA-UHFFFAOYSA-N 2-[benzyl(methyl)amino]ethanol Chemical compound OCCN(C)CC1=CC=CC=C1 WOUANPHGFPAJCA-UHFFFAOYSA-N 0.000 abstract 1
- JPXPPUOCSLMCHK-UHFFFAOYSA-N 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid Chemical compound COC(=O)C1=C(C)NC(C)=C(C(O)=O)C1C1=CC=CC([N+]([O-])=O)=C1 JPXPPUOCSLMCHK-UHFFFAOYSA-N 0.000 abstract 1
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- MCTRZKAKODSRLQ-UHFFFAOYSA-N dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC([N+]([O-])=O)=C1 MCTRZKAKODSRLQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960002289 nicardipine hydrochloride Drugs 0.000 abstract 1
- AIKVCUNQWYTVTO-UHFFFAOYSA-N nicardipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 AIKVCUNQWYTVTO-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU847/85A YU43409B (en) | 1985-05-21 | 1985-05-21 | Process for preparation 2-(n-benzile-n-methyl-amino)-ethyl methyl 2,6-dimethyl-4-(nitrophenyl)-1,4-dihydropiridine-3,5-dicarbooxilate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK8602336A true DK8602336A (en, 2012) | 1986-11-22 |
Family
ID=25551689
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK8602336D DK8602336A (en, 2012) | 1985-05-21 | ||
| DK233686A DK233686A (da) | 1985-05-21 | 1986-05-20 | Fremgangsmaade til fremstilling af 2-(n-benzyl-n-methylamino)-ethylmethyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydro-pyridin-3,5-dicarboxylat eller hydrochloridet deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK233686A DK233686A (da) | 1985-05-21 | 1986-05-20 | Fremgangsmaade til fremstilling af 2-(n-benzyl-n-methylamino)-ethylmethyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydro-pyridin-3,5-dicarboxylat eller hydrochloridet deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4769465A (en, 2012) |
| EP (1) | EP0202625B1 (en, 2012) |
| JP (1) | JPS6341459A (en, 2012) |
| AT (1) | ATE55122T1 (en, 2012) |
| DD (1) | DD247217A5 (en, 2012) |
| DE (1) | DE3673064D1 (en, 2012) |
| DK (2) | DK233686A (en, 2012) |
| FI (1) | FI83641C (en, 2012) |
| PL (1) | PL146201B1 (en, 2012) |
| SI (1) | SI8510847A8 (en, 2012) |
| SU (2) | SU1419516A3 (en, 2012) |
| YU (1) | YU43409B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3833893A1 (de) * | 1988-10-05 | 1990-04-12 | Bayer Ag | Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte |
| DE4041814A1 (de) * | 1990-12-24 | 1992-07-02 | Byk Gulden Lomberg Chem Fab | Verfahren zur herstellung von dihydrophyridincarbonsaeuren |
| JP3286645B2 (ja) * | 1993-03-26 | 2002-05-27 | メルシャン株式会社 | 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法 |
| US7585978B2 (en) * | 2006-11-28 | 2009-09-08 | Navinta Llc | Processes of manufacturing substituted-1,4-dihydropyridines, improved aqueous solutions thereof, and processes of manufacturing the solutions |
| ES2332168B1 (es) * | 2008-04-30 | 2010-10-27 | Consejo Superior De Investigaciones Cientificas (Csic) (75%) | Forma pseudopolimorfica de hidrocloruro de nicardipina, procedimiento para su preparacion y formulacion que la contiene. |
| CN113072483A (zh) * | 2021-03-30 | 2021-07-06 | 济南良福精合医药科技有限公司 | 盐酸尼卡地平的精制方法 |
| CN119613324A (zh) * | 2025-02-17 | 2025-03-14 | 广州市桐晖药业有限公司 | 一种盐酸尼卡地平的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2218644C3 (de) * | 1972-04-18 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| US3974275A (en) * | 1972-04-18 | 1976-08-10 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives |
| US3996234A (en) * | 1972-04-18 | 1976-12-07 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
| JPS5930704B2 (ja) * | 1973-02-20 | 1984-07-28 | 山之内製薬株式会社 | 新規１，４−ジヒドロピリジン誘導体の製法 |
| US4285955A (en) * | 1978-10-31 | 1981-08-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridinecarboxylic acids |
| DE2847237A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Verfahren zur herstellung von 1,4-dihydropyridincarbonsaeuren sowie ihre verwendung als arzneimittel |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4483985A (en) * | 1978-10-31 | 1984-11-20 | Bayer Aktiengesellschaft | Production of 1,4-dihydropyridinecarboxylic acids |
| JPS59137461A (ja) * | 1983-01-27 | 1984-08-07 | Kyowa Hakko Kogyo Co Ltd | １，４−ジヒドロピリジン誘導体 |
| ZA848907B (en) * | 1983-11-16 | 1985-06-26 | Ciba Geigy Ag | Novel amide compounds |
| US4672068A (en) * | 1984-05-04 | 1987-06-09 | Fujirebio Kabushiki Kaisha | Antihypertensive 1,4-dihydropyridines having a conjugated ester |
| JPS6124567A (ja) * | 1984-07-13 | 1986-02-03 | Taisho Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
| JPS6124568A (ja) * | 1984-07-13 | 1986-02-03 | Taisho Pharmaceut Co Ltd | ジヒドロピリジンエステルの製造法 |
-
0
- DK DK8602336D patent/DK8602336A/da unknown
-
1985
- 1985-05-21 SI SI8510847A patent/SI8510847A8/sl unknown
- 1985-05-21 YU YU847/85A patent/YU43409B/xx unknown
-
1986
- 1986-05-14 US US06/862,938 patent/US4769465A/en not_active Expired - Fee Related
- 1986-05-16 AT AT86106700T patent/ATE55122T1/de not_active IP Right Cessation
- 1986-05-16 DE DE8686106700T patent/DE3673064D1/de not_active Expired - Lifetime
- 1986-05-16 EP EP86106700A patent/EP0202625B1/de not_active Expired - Lifetime
- 1986-05-20 DK DK233686A patent/DK233686A/da not_active Application Discontinuation
- 1986-05-20 PL PL1986259577A patent/PL146201B1/pl unknown
- 1986-05-20 FI FI862111A patent/FI83641C/fi not_active IP Right Cessation
- 1986-05-20 SU SU864027513A patent/SU1419516A3/ru active
- 1986-05-20 DD DD86290391A patent/DD247217A5/de not_active IP Right Cessation
- 1986-08-01 JP JP61180258A patent/JPS6341459A/ja active Granted
-
1987
- 1987-04-10 SU SU874202339A patent/SU1493104A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU1419516A3 (ru) | 1988-08-23 |
| PL146201B1 (en) | 1989-01-31 |
| DD247217A5 (de) | 1987-07-01 |
| ATE55122T1 (de) | 1990-08-15 |
| DK233686D0 (da) | 1986-05-20 |
| FI83641B (fi) | 1991-04-30 |
| JPH0521105B2 (en, 2012) | 1993-03-23 |
| EP0202625A3 (en) | 1987-07-01 |
| JPS6341459A (ja) | 1988-02-22 |
| FI862111A0 (fi) | 1986-05-20 |
| US4769465A (en) | 1988-09-06 |
| YU43409B (en) | 1989-06-30 |
| DK233686A (da) | 1986-11-22 |
| FI83641C (fi) | 1991-08-12 |
| EP0202625B1 (de) | 1990-08-01 |
| DE3673064D1 (de) | 1990-09-06 |
| SI8510847A8 (en) | 1996-04-30 |
| FI862111A7 (fi) | 1986-11-22 |
| SU1493104A3 (ru) | 1989-07-07 |
| EP0202625A2 (de) | 1986-11-26 |
| YU84785A (en) | 1987-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT89122A (pt) | Processo para a preparacao de tiazolidinodionas uteis como agentes hipoglicemicos e anti-aterosclerose | |
| HUT50316A (en) | Process for production of 1-phenyl-3-naphthyl-oxy-propanamines and pharmaceutical preparations containing them | |
| EP0060897B1 (en) | 1,4-dihydropyridine-3,5-dicarboxylic ester derivatives | |
| DK0402752T3 (da) | N-Heteroaryl-purin-6-aminer, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler | |
| EP0233150A3 (en) | Process for the preparation of 2-(imidazolin-2-yl)-pyridine and like quinoline-3-carboxylic acids | |
| DK8602336A (en, 2012) | ||
| PT96175A (pt) | Processo para a preparacao de acidos oxoftalazinil acetico substituidos e seus analogos | |
| ATE82569T1 (de) | Herstellung von chinolincarbonsaeuren. | |
| DE3678665D1 (de) | N-alkylierung von dihydrolysergsaeure. | |
| BR8900317A (pt) | Processo para a preparacao de compostos herbicidas e compostos herbicidas | |
| JPS6440467A (en) | Novel substituted diphenylimidazole derivative | |
| NZ233196A (en) | Process for preparing glutaric acid derivatives and 2-alkoxycarbonylalkyl cyclohexanone derivatives | |
| ES8306364A1 (es) | "procedimiento para la preparacion de un derivado de 1,4-dehidropirimidina". | |
| ES2128304T3 (es) | Procedimiento para preparar 5-arilhidantoina. | |
| DK0557519T3 (da) | Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan | |
| ES8606277A1 (es) | Procedimiento de preparacion del 2,6-dimetil-5-metoxicarbo- nil-4-(3-nitrofenil)-1,4-dihidropiridina-3-carboxilato de etilo | |
| TH2896A (th) | กรรมวิธีการเตรียมพิริดาชิแนมีนที่ว่องไวในการต่อต้านไวรัส | |
| TH2350A (th) | เกลือต่าง ๆ ของสารประกอบฟีแนนธรีนเมธานอลที่ใช้ป้องกันและรักษาโรคมาเลเรีย |