PT96175A - Processo para a preparacao de acidos oxoftalazinil acetico substituidos e seus analogos - Google Patents

Processo para a preparacao de acidos oxoftalazinil acetico substituidos e seus analogos

Info

Publication number
PT96175A
PT96175A PT96175A PT9617590A PT96175A PT 96175 A PT96175 A PT 96175A PT 96175 A PT96175 A PT 96175A PT 9617590 A PT9617590 A PT 9617590A PT 96175 A PT96175 A PT 96175A
Authority
PT
Portugal
Prior art keywords
substituted
oxoftalazinyl
analogs
preparation
acid acids
Prior art date
Application number
PT96175A
Other languages
English (en)
Other versions
PT96175B (pt
Inventor
Banavara Lakshmana Mylari
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT96175A publication Critical patent/PT96175A/pt
Publication of PT96175B publication Critical patent/PT96175B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT96175A 1989-12-15 1990-12-13 Processo para a preparacao de acidos oxoftalazinil acetico substituidos e seus analogos PT96175B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/005637 WO1991009019A1 (en) 1989-12-15 1989-12-15 Substituted oxophthalazinyl acetic acids and analogs thereof

Publications (2)

Publication Number Publication Date
PT96175A true PT96175A (pt) 1991-09-30
PT96175B PT96175B (pt) 1998-04-30

Family

ID=22215419

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96175A PT96175B (pt) 1989-12-15 1990-12-13 Processo para a preparacao de acidos oxoftalazinil acetico substituidos e seus analogos

Country Status (13)

Country Link
US (1) US5304557A (pt)
EP (1) EP0436307B1 (pt)
JP (1) JPH0660163B2 (pt)
AT (1) ATE118768T1 (pt)
CA (1) CA2032231C (pt)
DE (1) DE69017174T2 (pt)
DK (1) DK0436307T3 (pt)
ES (1) ES2068350T3 (pt)
FI (1) FI922308A0 (pt)
GR (1) GR3015852T3 (pt)
IE (1) IE65294B1 (pt)
PT (1) PT96175B (pt)
WO (1) WO1991009019A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682108B1 (fr) * 1991-10-07 1994-01-07 Lipha Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
YU59600A (sh) 1998-03-31 2002-12-10 The Institute For Pharmaceutical Discovery Inc. Supstituisane indolalkanoidske kiseline
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
MXPA05001011A (es) * 2002-07-26 2005-06-08 Inst For Pharm Discovery Inc Derivado de acidos indolalcanoicos substituidos y formulaciones que lo contienen para uso en tratamiento de complicaciones diabeticas.
KR100843352B1 (ko) * 2007-01-30 2008-07-03 한국과학기술연구원 세로토닌 수용체 5-ＨＴ2ａ 또는 5-ＨＴ2ｃ의 길항제로활성을 갖는 1,2-다이하이드로-1-옥소프탈라지닐 피페라진화합물 및 이의 제조방법
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
EP3192796B1 (en) 2010-07-16 2019-09-04 The Trustees of Columbia University in the City of New York Aldose reductase inhibitors and uses thereof
SI3352754T1 (sl) 2016-06-21 2021-03-31 The Trustees Of Columbia University In The City Of New York Zaviralci aldozne reduktaze in postopki njihove uporabe
CA3071114A1 (en) 2017-07-28 2019-01-31 Applied Therapeutics Inc. Compositions and methods for treating galactosemia
JP7457033B2 (ja) * 2019-02-28 2024-03-27 石薬集団中奇制薬技術（石家庄）有限公司 アルドース還元酵素阻害剤の塩、及びその製造方法と使用
JP2022519944A (ja) 2019-04-01 2022-03-25 アプライド セラピューティクス インコーポレイテッド アルドースレダクターゼの阻害剤
AU2021279305A1 (en) * 2020-05-28 2023-02-09 Janssen Pharmaceutica Nv Compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3003249A1 (de) * 1980-01-30 1981-08-06 Henkel KGaA, 4000 Düsseldorf Mittel zum nachbehandeln gewaschener waesche in einem waeschetrockner
US4904478A (en) * 1983-08-11 1990-02-27 Mission Pharmacal Company Slow-release sodium fluoride tablet and method for treatment of osteoporosis
US4939140A (en) * 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
ES2032749T3 (es) * 1985-11-07 1993-03-01 Pfizer Inc. Acidos oxoftalazinil-aceticos heterociclicos.
US4868301A (en) * 1987-06-09 1989-09-19 Pfizer Inc. Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate

Also Published As

Publication number Publication date
EP0436307B1 (en) 1995-02-22
EP0436307A1 (en) 1991-07-10
IE65294B1 (en) 1995-10-18
IE904508A1 (en) 1991-06-19
US5304557A (en) 1994-04-19
CA2032231C (en) 1995-08-22
JPH0660163B2 (ja) 1994-08-10
FI922308A (fi) 1992-05-21
CA2032231A1 (en) 1991-06-16
DK0436307T3 (da) 1995-05-08
DE69017174T2 (de) 1995-06-14
ATE118768T1 (de) 1995-03-15
PT96175B (pt) 1998-04-30
GR3015852T3 (en) 1995-07-31
FI922308A0 (fi) 1992-05-21
DE69017174D1 (de) 1995-03-30
ES2068350T3 (es) 1995-04-16
WO1991009019A1 (en) 1991-06-27
JPH03258766A (ja) 1991-11-19

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910509

FG3A Patent granted, date of granting

Effective date: 19980113

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000731