PL118478B1 - Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cyclohept-5,10-enoimineszo-/a,d/ciklogepteno-5,10-iminov - Google Patents

Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cyclohept-5,10-enoimineszo-/a,d/ciklogepteno-5,10-iminov Download PDF

Info

Publication number
PL118478B1
PL118478B1 PL1978217435A PL21743578A PL118478B1 PL 118478 B1 PL118478 B1 PL 118478B1 PL 1978217435 A PL1978217435 A PL 1978217435A PL 21743578 A PL21743578 A PL 21743578A PL 118478 B1 PL118478 B1 PL 118478B1
Authority
PL
Poland
Prior art keywords
dibenzo
dihydro
formula
imine
cycloheptene
Prior art date
Application number
PL1978217435A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL118478B1 publication Critical patent/PL118478B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL1978217435A 1977-09-19 1978-09-16 Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cyclohept-5,10-enoimineszo-/a,d/ciklogepteno-5,10-iminov PL118478B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (1)

Publication Number Publication Date
PL118478B1 true PL118478B1 (en) 1981-10-31

Family

ID=25267426

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1978217435A PL118478B1 (en) 1977-09-19 1978-09-16 Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cyclohept-5,10-enoimineszo-/a,d/ciklogepteno-5,10-iminov
PL1978209632A PL112834B1 (en) 1977-09-19 1978-09-16 Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cycloheptene-5,10-imines
PL1978225938A PL121605B1 (en) 1977-09-19 1978-09-16 Proces for preparing 5-substituted 10,11-dihydro-5h-dibenzo-/a,d/cyclohepteno-5,10-imineszo ciklogepten-5,10-iminov

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL1978209632A PL112834B1 (en) 1977-09-19 1978-09-16 Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cycloheptene-5,10-imines
PL1978225938A PL121605B1 (en) 1977-09-19 1978-09-16 Proces for preparing 5-substituted 10,11-dihydro-5h-dibenzo-/a,d/cyclohepteno-5,10-imineszo ciklogepten-5,10-iminov

Country Status (33)

Country Link
JP (1) JPS5463100A (enFirst)
AR (1) AR231544A1 (enFirst)
AT (1) AT370103B (enFirst)
AU (1) AU520178B2 (enFirst)
BE (1) BE870562A (enFirst)
CA (1) CA1129850A (enFirst)
CH (1) CH637954A5 (enFirst)
CY (1) CY1283A (enFirst)
DE (1) DE2840786A1 (enFirst)
DK (1) DK153843C (enFirst)
ES (7) ES473492A1 (enFirst)
FI (1) FI65618C (enFirst)
FR (1) FR2403334A1 (enFirst)
GB (2) GB2004872B (enFirst)
GR (1) GR65703B (enFirst)
HK (1) HK30885A (enFirst)
HU (1) HU180868B (enFirst)
IE (1) IE47355B1 (enFirst)
IL (1) IL55521A0 (enFirst)
IT (1) IT1113279B (enFirst)
KE (1) KE3501A (enFirst)
LU (1) LU80262A1 (enFirst)
NL (1) NL191488C (enFirst)
NO (1) NO151861C (enFirst)
NZ (1) NZ188361A (enFirst)
PH (1) PH15920A (enFirst)
PL (3) PL118478B1 (enFirst)
PT (1) PT68544A (enFirst)
SE (1) SE437520B (enFirst)
SG (1) SG9585G (enFirst)
SU (2) SU895288A3 (enFirst)
YU (1) YU41432B (enFirst)
ZA (1) ZA785291B (enFirst)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
ES2843724T3 (es) 2015-11-30 2021-07-20 Inst Nat Sante Rech Med Antagonistas de NMDAR para el tratamiento de la angiogénesis tumoral

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Also Published As

Publication number Publication date
HU180868B (en) 1983-04-29
HK30885A (en) 1985-04-26
FR2403334A1 (fr) 1979-04-13
DE2840786A1 (de) 1979-03-22
IT7851126A0 (it) 1978-09-18
PT68544A (en) 1978-10-01
GB2061947B (en) 1982-08-04
GB2004872B (en) 1982-04-15
PL112834B1 (en) 1980-11-29
DK153843B (da) 1988-09-12
IE47355B1 (en) 1984-02-22
PL121605B1 (en) 1982-05-31
AR231544A1 (es) 1984-12-28
SE7809187L (sv) 1979-03-20
SG9585G (en) 1985-08-08
SU915800A3 (en) 1982-03-23
IE781866L (en) 1979-03-19
SE437520B (sv) 1985-03-04
SU895288A3 (ru) 1981-12-30
DK389978A (da) 1979-03-20
IL55521A0 (en) 1978-12-17
YU41432B (en) 1987-06-30
YU219678A (en) 1983-02-28
NL191488C (nl) 1995-08-04
NO783017L (no) 1979-03-20
NO151861B (no) 1985-03-11
GR65703B (en) 1980-10-22
CH637954A5 (de) 1983-08-31
AT370103B (de) 1983-03-10
GB2061947A (en) 1981-05-20
ES483284A1 (es) 1980-09-01
ES483286A1 (es) 1980-04-16
NL7808847A (nl) 1979-03-21
ES473492A1 (es) 1980-07-16
NZ188361A (en) 1982-06-29
DE2840786C2 (enFirst) 1987-05-21
AU3966878A (en) 1980-03-13
PH15920A (en) 1983-04-22
BE870562A (fr) 1979-03-19
IT1113279B (it) 1986-01-20
CA1129850A (en) 1982-08-17
ES483283A1 (es) 1980-04-16
DK153843C (da) 1989-01-23
FR2403334B1 (enFirst) 1982-11-19
ZA785291B (en) 1980-04-30
JPS5463100A (en) 1979-05-21
CY1283A (en) 1985-07-05
ES483287A1 (es) 1980-04-16
LU80262A1 (fr) 1979-06-01
FI65618B (fi) 1984-02-29
ES483288A1 (es) 1980-04-16
NO151861C (no) 1985-06-19
FI782680A7 (fi) 1979-03-20
GB2004872A (en) 1979-04-11
PL209632A1 (pl) 1979-06-04
FI65618C (fi) 1984-06-11
ATA669778A (de) 1982-07-15
JPS5639315B2 (enFirst) 1981-09-11
ES483285A1 (es) 1980-09-01
KE3501A (en) 1985-02-22
AU520178B2 (en) 1982-01-21
NL191488B (nl) 1995-04-03

Similar Documents

Publication Publication Date Title
DE69724108T2 (de) Isochinolinderivate und arzneimittel
JPH0255416B2 (enFirst)
EP3310785B1 (en) Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP2000500786A (ja) エーテルムスカリン様アンタゴニスト
EA023751B1 (ru) Набор, композиция, продукт или лекарственное средство для лечения нарушения познавательной способности
BG60411B2 (bg) Бис-диметоксиметил(триметоксибензил)изохинолинови соли, получаване и фармацевтични състави,които ги съдържат
DE69111816T4 (de) Indolederivate und ihre verwendung als serotonin-antagoniste.
AU2010200563A1 (en) Bicyclic amides for enhancing glutamatergic synaptic responses
CA3135409A1 (en) Pyrrolopyrimidine inhibitors of wild-type and mutant forms of lrrk2
JP2021523934A (ja) ミトコンドリア脱共役剤として有用なアミノピラジンおよび関連化合物
JP2002179651A (ja) ベンズアニリド誘導体及び医薬組成物
DE3788195T2 (de) DIBENZ[b,e]OXEPINDERIVATE, SOWIE ARZNEIMITTEL, DIE DIESE ALS AKTIVE MITTEL ENTHALTEN.
PL118478B1 (en) Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cyclohept-5,10-enoimineszo-/a,d/ciklogepteno-5,10-iminov
CA2792918C (en) Benzazepine compound
AU760009B2 (en) Bis-quaternary ammonium derivatives as neuromuscular relaxants
IE911304A1 (en) 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
KR950007756B1 (ko) 피리미딘 화합물 및 그의 약학적으로 허용되는 염류
US2807617A (en) Acylpiperazines and methods of preparing the same
US20100173903A1 (en) Bicyclic amide derivatives for the treatmet of respiratory disorders
HU205931B (en) Process for producing pyrrolo-pyrimidine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them as active components
CA1087987A (en) Pharmaceutical composition containing 3- phenoxypyridine
PL144481B1 (en) Process for preparing derivatives of pyrimidinotrione
BR112020005992A2 (pt) novos sais
EA017630B1 (ru) ЗАМЕЩЕННЫЕ 3-АРИЛСУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ, АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT-РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
US4831049A (en) Pyrrolizidine compounds, and their use as antiarrhythmic agents