PH18529A - Anti-tumor quinazoline compounds - Google Patents

Anti-tumor quinazoline compounds

Info

Publication number
PH18529A
PH18529A PH26788A PH26788A PH18529A PH 18529 A PH18529 A PH 18529A PH 26788 A PH26788 A PH 26788A PH 26788 A PH26788 A PH 26788A PH 18529 A PH18529 A PH 18529A
Authority
PH
Philippines
Prior art keywords
tumor
quinazoline compounds
quinazoline
compounds
tumor quinazoline
Prior art date
Application number
PH26788A
Other languages
English (en)
Inventor
William E Kreighbaum
William T Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of PH18529A publication Critical patent/PH18529A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH26788A 1981-03-06 1982-01-25 Anti-tumor quinazoline compounds PH18529A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (1)

Publication Number Publication Date
PH18529A true PH18529A (en) 1985-08-02

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
PH26788A PH18529A (en) 1981-03-06 1982-01-25 Anti-tumor quinazoline compounds

Country Status (31)

Country Link
US (1) US4343940A (ro)
JP (1) JPS57158780A (ro)
KR (1) KR880001852B1 (ro)
AR (1) AR231138A1 (ro)
AT (1) AT380476B (ro)
AU (1) AU556099B2 (ro)
BE (1) BE891936A (ro)
CA (1) CA1163995A (ro)
CH (1) CH647776A5 (ro)
CY (1) CY1371A (ro)
DE (1) DE3203770C2 (ro)
DK (1) DK159442C (ro)
ES (1) ES8304095A1 (ro)
FI (1) FI71559C (ro)
FR (1) FR2501207B1 (ro)
GB (1) GB2094295B (ro)
GR (1) GR75903B (ro)
HK (1) HK4588A (ro)
HU (1) HU189997B (ro)
IE (1) IE52385B1 (ro)
IL (1) IL64875A0 (ro)
IT (1) IT1154272B (ro)
KE (1) KE3715A (ro)
LU (1) LU83903A1 (ro)
NL (1) NL8200473A (ro)
NZ (1) NZ199576A (ro)
PH (1) PH18529A (ro)
PT (1) PT74394B (ro)
SE (1) SE461732B (ro)
SG (1) SG30787G (ro)
YU (1) YU42031B (ro)

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US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
EP0634169B1 (en) * 1993-06-29 2000-01-05 Takeda Chemical Industries, Ltd. Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis
JP2890267B2 (ja) * 1994-02-23 1999-05-10 ファイザー インク． ４−ヘテロサイクリル−置換キナゾリン誘導体、その調製法および抗癌剤としてのその使用法
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (ro) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
AU5343096A (en) * 1995-04-27 1996-11-18 Zeneca Limited Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
EP0860433B1 (en) * 1995-11-07 2002-07-03 Kirin Beer Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US6184225B1 (en) 1996-02-13 2001-02-06 Zeneca Limited Quinazoline derivatives as VEGF inhibitors
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab, Soedertaelje 4-anilinochinazolin derivate
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
ATE271603T1 (de) * 1996-12-11 2004-08-15 Sugen Inc Identifizierungsverfahren für substanzen die an das pyk2 polypeptid binden
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
EP1049786A2 (en) * 1998-01-21 2000-11-08 Sugen, Inc. Human orthologues of wart
EP1073723B1 (en) 1998-04-14 2005-08-17 Sugen, Inc. Ste20-related protein kinases
AU4317399A (en) 1998-05-28 1999-12-13 Parker Hughes Institute Quinazolines for treating brain tumor
US6800649B1 (en) 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
WO2000010981A1 (en) 1998-08-21 2000-03-02 Parker Hughes Institute Quinazoline derivatives
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
AU783082B2 (en) 1999-10-22 2005-09-22 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
ES2306306T3 (es) 1999-11-05 2008-11-01 Astrazeneca Ab Nuevos derivados de quinazolina.
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
EP1265925A2 (en) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors
ATE334973T1 (de) * 2000-04-07 2006-08-15 Astrazeneca Ab Chinazolinverbindungen
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
CN100491374C (zh) 2002-08-02 2009-05-27 Ab科学公司 2-(3-氨基芳基)氨基-4-芳基-噻唑及其作为c-kit抑制剂的应用
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
WO2005040139A2 (en) * 2003-10-23 2005-05-06 Ab Science 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
JP5204643B2 (ja) 2005-04-04 2013-06-05 アブ サイエンス 置換オキサゾール誘導体、およびチロシンキナーゼ阻害薬としてのそれらの使用
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP2088863A2 (en) * 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
SG10201601711SA (en) 2011-03-04 2016-04-28 Newgen Therapeutics Inc Alkyne Substituted Quinazoline Compound And Methods Of Use

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US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
AU438472B2 (en) * 1970-12-23 1973-08-09 Sumitomo Chemical Company, Limited Quinazolinone derivatives anda process for production thereof
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
DE3203770A1 (de) 1982-11-11
CA1163995A (en) 1984-03-20
AR231138A1 (es) 1984-09-28
YU25682A (en) 1985-03-20
AU556099B2 (en) 1986-10-23
IE52385B1 (en) 1987-10-14
DK159442C (da) 1991-03-18
AT380476B (de) 1986-05-26
IL64875A0 (en) 1982-03-31
GR75903B (ro) 1984-08-02
KE3715A (en) 1987-04-16
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
ES509434A0 (es) 1983-02-16
JPS57158780A (en) 1982-09-30
FR2501207B1 (fr) 1985-12-06
ES8304095A1 (es) 1983-02-16
NL8200473A (nl) 1982-10-01
FI71559C (fi) 1987-01-19
DE3203770C2 (de) 1993-11-04
JPH0337552B2 (ro) 1991-06-05
SE461732B (sv) 1990-03-19
KR880001852B1 (ko) 1988-09-22
DK159442B (da) 1990-10-15
ATA39582A (de) 1985-10-15
PT74394A (en) 1982-03-01
GB2094295A (en) 1982-09-15
IT1154272B (it) 1987-01-21
KR830009050A (ko) 1983-12-17
LU83903A1 (fr) 1982-09-13
FR2501207A1 (fr) 1982-09-10
PT74394B (en) 1984-10-22
YU42031B (en) 1988-04-30
IT8247713A1 (it) 1983-08-03
NZ199576A (en) 1986-05-09
DK50482A (da) 1982-09-07
AU7998182A (en) 1982-09-09
GB2094295B (en) 1984-09-12
CY1371A (en) 1987-08-07
IT8247713A0 (it) 1982-02-03
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06
CH647776A5 (de) 1985-02-15
BE891936A (fr) 1982-07-28
HU189997B (en) 1986-08-28
HK4588A (en) 1988-01-29
FI71559B (fi) 1986-10-10
SE8200526L (sv) 1982-09-07

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