ATE271603T1 - Identifizierungsverfahren für substanzen die an das pyk2 polypeptid binden - Google Patents

Identifizierungsverfahren für substanzen die an das pyk2 polypeptid binden

Info

Publication number
ATE271603T1
ATE271603T1 AT97952333T AT97952333T ATE271603T1 AT E271603 T1 ATE271603 T1 AT E271603T1 AT 97952333 T AT97952333 T AT 97952333T AT 97952333 T AT97952333 T AT 97952333T AT E271603 T1 ATE271603 T1 AT E271603T1
Authority
AT
Austria
Prior art keywords
bind
substances
identification method
features
pyk2 polypeptide
Prior art date
Application number
AT97952333T
Other languages
English (en)
Inventor
Simma Lev
Joseph Schlessinger
Original Assignee
Sugen Inc
Univ New York Medical Ct
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Univ New York Medical Ct filed Critical Sugen Inc
Application granted granted Critical
Publication of ATE271603T1 publication Critical patent/ATE271603T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Confectionery (AREA)
  • Tires In General (AREA)
AT97952333T 1996-12-11 1997-12-09 Identifizierungsverfahren für substanzen die an das pyk2 polypeptid binden ATE271603T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3282496P 1996-12-11 1996-12-11
PCT/US1997/022565 WO1998026054A2 (en) 1996-12-11 1997-12-09 Pyk2 related products and methods

Publications (1)

Publication Number Publication Date
ATE271603T1 true ATE271603T1 (de) 2004-08-15

Family

ID=21867009

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97952333T ATE271603T1 (de) 1996-12-11 1997-12-09 Identifizierungsverfahren für substanzen die an das pyk2 polypeptid binden

Country Status (11)

Country Link
US (2) US20020048782A1 (de)
EP (1) EP0948604B1 (de)
JP (1) JP2001505779A (de)
AT (1) ATE271603T1 (de)
AU (1) AU5596998A (de)
CA (1) CA2274805A1 (de)
DE (1) DE69729954T2 (de)
DK (1) DK0948604T3 (de)
ES (1) ES2227729T3 (de)
PT (1) PT948604E (de)
WO (1) WO1998026054A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
EP1630559A3 (de) * 1998-12-30 2006-06-07 Sugen, Inc. PYK2 (RAFTK) und Entzündung
EP1141722A1 (de) * 1998-12-31 2001-10-10 Sugen, Inc. Pyk2 (raftk) und entzündung
DE19860833C1 (de) 1998-12-30 2000-09-07 Albrecht E Sippel Methode zur zellulären High-Throughput(Hochdurchsatz)-Detektion von Rezeptor-Liganden-Interaktionen
CA2362943A1 (en) * 1999-02-22 2000-08-24 Joseph Schlessinger Pyk2 binding proteins
DE10037759A1 (de) * 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
EP1228766A1 (de) * 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PYK2 Phosphorylierung durch HER3 induziert Tumorinvasion
DE10123055A1 (de) * 2001-05-11 2003-03-20 Gruenenthal Gmbh Screeningverfahren mit PIM1-Kinase oder PIM3-Kinase
DE10128541A1 (de) * 2001-06-13 2003-02-20 Gruenenthal Gmbh Screening-Verfahren mit BNPI und DNPI
JP2005514013A (ja) * 2001-12-19 2005-05-19 ミレニアム・ファーマシューティカルズ・インコーポレイテッド １４６５、１５８７、２１４６、２２０７、３２８３８、３３６、および５２９０８を使用して疼痛および有痛性障害を処置する際の方法および組成物
US20040171062A1 (en) * 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
EP1546372A4 (de) * 2002-09-19 2006-08-23 Pfizer Prod Inc Zellassay mit induzierbarer fokaler adhäsionskinase
US20050170431A1 (en) * 2003-02-28 2005-08-04 Plexxikon, Inc. PYK2 crystal structure and uses
WO2005002573A2 (en) * 2003-06-06 2005-01-13 Elan Pharmaceuticals, Inc. Methods for using modulators of proline-rich tyrosine kinase 2
US20050148029A1 (en) * 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
US8552155B2 (en) * 2008-05-28 2013-10-08 Mayo Foundation For Medical Education And Research Anti-Pyk2 antibodies
TWI630916B (zh) 2009-11-13 2018-08-01 第一三共歐洲公司 供治療或預防人表皮生長因子受體－３（ｈｅｒ－３）相關疾病之藥料和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343940A (en) * 1979-02-13 1982-08-10 Mead Johnson & Company Anti-tumor quinazoline compounds
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
DE3611194A1 (de) * 1986-04-04 1987-10-08 Bayer Ag Cancerostatisches mittel
DE3920029C2 (de) * 1988-06-30 1999-05-20 Clariant Finance Bvi Ltd Farbstoffe zum Färben von Kunststoffen
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease

Also Published As

Publication number Publication date
AU5596998A (en) 1998-07-03
DE69729954D1 (de) 2004-08-26
ES2227729T3 (es) 2005-04-01
WO1998026054A2 (en) 1998-06-18
US20020048782A1 (en) 2002-04-25
EP0948604A2 (de) 1999-10-13
EP0948604B1 (de) 2004-07-21
CA2274805A1 (en) 1998-06-18
PT948604E (pt) 2004-10-29
DK0948604T3 (da) 2004-11-22
DE69729954T2 (de) 2005-09-08
JP2001505779A (ja) 2001-05-08
WO1998026054A3 (en) 1998-09-03
US20030119067A1 (en) 2003-06-26

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