DE69628758D1 - Identifikation von mutationen, die mit menschlicher alpha-thalassämie assoziiert sind, und ihre verwendung für die vorhersage von blutkrankheiten. - Google Patents

Identifikation von mutationen, die mit menschlicher alpha-thalassämie assoziiert sind, und ihre verwendung für die vorhersage von blutkrankheiten.

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Publication number
DE69628758D1
DE69628758D1 DE69628758T DE69628758T DE69628758D1 DE 69628758 D1 DE69628758 D1 DE 69628758D1 DE 69628758 T DE69628758 T DE 69628758T DE 69628758 T DE69628758 T DE 69628758T DE 69628758 D1 DE69628758 D1 DE 69628758D1
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DE
Germany
Prior art keywords
prediction
identification
human alpha
mutations associated
blood diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69628758T
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English (en)
Inventor
Lemuel J Bowie
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Individual
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Individual
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Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69628758D1 publication Critical patent/DE69628758D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69628758T 1995-10-31 1996-10-30 Identifikation von mutationen, die mit menschlicher alpha-thalassämie assoziiert sind, und ihre verwendung für die vorhersage von blutkrankheiten. Expired - Lifetime DE69628758D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/550,715 US5750345A (en) 1995-10-31 1995-10-31 Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
PCT/US1996/017565 WO1997016568A1 (en) 1995-10-31 1996-10-30 DETECTION OF HUMAN α-THALASSEMIA MUTATIONS AND THEIR USE AS PREDICTORS OF BLOOD-RELATED DISORDERS

Publications (1)

Publication Number Publication Date
DE69628758D1 true DE69628758D1 (de) 2003-07-24

Family

ID=24198323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628758T Expired - Lifetime DE69628758D1 (de) 1995-10-31 1996-10-30 Identifikation von mutationen, die mit menschlicher alpha-thalassämie assoziiert sind, und ihre verwendung für die vorhersage von blutkrankheiten.

Country Status (5)

Country Link
US (1) US5750345A (de)
EP (1) EP0859863B1 (de)
JP (1) JP2000501923A (de)
DE (1) DE69628758D1 (de)
WO (1) WO1997016568A1 (de)

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US20020187483A1 (en) * 2001-04-20 2002-12-12 Cerner Corporation Computer system for providing information about the risk of an atypical clinical event based upon genetic information
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20030162174A1 (en) * 2001-06-11 2003-08-28 Sutherland John W. Detecting nucleic acid deletion sequences
US20040142403A1 (en) * 2001-08-13 2004-07-22 Donald Hetzel Method of screening for disorders of glucose metabolism
AU2002343417A1 (en) * 2001-09-24 2003-04-14 Nuvelo Novel nucleic acids and polypeptides
EP2277532A1 (de) * 2002-09-11 2011-01-26 Genentech, Inc. Neuartige Zusammensetzung und Verfahren zur Behandlung von Immunerkrankungen
JP5392980B2 (ja) * 2003-03-27 2014-01-22 チルドレンズ ホスピタル メディカル センター 早発型の腎尿細管細胞障害を検出するための方法およびキット
EP1519194A1 (de) 2003-09-24 2005-03-30 Roche Diagnostics GmbH Die Verwendung von GFAP zur Identifizierung einer Intrazerebralblutung
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
DE602005024850D1 (de) * 2004-09-24 2010-12-30 Beth Israel Hospital Verfahren zur diagnose und behandlung von schwangerschaftsskomplikationen
PL1831699T3 (pl) * 2004-12-20 2010-04-30 Antibodyshop As Oznaczanie lipokaliny neutrofilowej związanej z żelatynazą (NGAL) jako markera diagnostycznego dla zaburzeń nerek
US20070037232A1 (en) * 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
EP1975614A4 (de) * 2005-12-22 2010-06-09 Shionogi & Co Verfahren für die vorhersage bzw. prognose von akutem koronarsyndrom
WO2007116779A1 (ja) * 2006-03-31 2007-10-18 Mochida Pharmaceutical Co., Ltd. 新規血小板活性化マーカー及びその測定方法
WO2007116975A1 (ja) * 2006-04-06 2007-10-18 Eisai R & D Management Co., Ltd. チトクロムｃの定量による非アルコール性脂肪性肝炎の非侵襲的な検査方法及び検査キット
US20090197280A1 (en) 2006-05-30 2009-08-06 Kristian Bangert Methods and Devices for Rapid Assessment of Severity of Injury
US20090286271A1 (en) * 2006-05-31 2009-11-19 Karumanchi Ananth S Methods of Diagnosing and Treating Complications of Pregnancy
EP2064553B2 (de) * 2006-08-07 2023-06-07 Antibodyshop A/S Diagnostischer test zum ausschliessen einer signifikanten nierenverletzung
US20080050749A1 (en) * 2006-08-17 2008-02-28 Ildiko Amann-Zalan Use of bnp-type peptides for the stratification of therapy with erythropoietic stimulating agents
US20080124712A1 (en) * 2006-10-26 2008-05-29 Hantash Feras M Alpha globin gene dosage assay
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HUE036780T2 (hu) 2008-04-09 2018-07-30 Genentech Inc Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
TWI354789B (en) * 2008-07-18 2011-12-21 Univ Kaohsiung Medical Il-8 as biomarker for the detection of urolithiasi
SI2384368T1 (sl) * 2009-01-30 2016-04-29 Kantonsspital Aarau Ag Analiza genskega odmerjanja
DK2405928T3 (en) * 2009-03-11 2017-01-30 Promedior Inc Treatment and diagnosis procedure for hypersensitive diseases
ES2684493T3 (es) * 2009-03-11 2018-10-03 Promedior Inc. Un polipéptido SAP para uso en el tratamiento de trastornos autoinmunitarios y enfermedad del injerto contra el huésped
UA110323C2 (en) * 2009-06-04 2015-12-25 Promedior Inc Derivative of serum amyloid p and their receipt and application
US8329659B2 (en) 2009-06-17 2012-12-11 Promedior, Inc. SAP variants and their use
US20120135425A1 (en) * 2010-08-23 2012-05-31 The Ohio State University Research Foundation ELISA for Haptoglobin-Matrix Metalloproteinase 9 Complex as a Diagnostic Test for Conditions Including Acute Inflammation
US20120045778A1 (en) * 2010-08-23 2012-02-23 The Ohio State University Research Foundation Elisa for haptoglobin-matrix metalloproteinase 9 complex as a diagnostic test for conditions including acute inflammation
WO2014191981A1 (en) * 2013-05-28 2014-12-04 Ramot At Tel-Aviv University Ltd. Detection of hydroxymethylcytosine bases
PT3021869T (pt) 2013-07-16 2020-09-10 Hoffmann La Roche Métodos de tratamento do cancro com antagonistas da ligação ao eixo pd-1 e inibidores do tigit
RU2732591C2 (ru) 2015-09-25 2020-09-21 Дженентек, Инк. Анти-tigit антитела и способы применения
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CN112080558B (zh) * 2019-06-13 2024-03-12 杭州贝瑞和康基因诊断技术有限公司 同时检测hba1/2和hbb基因突变的试剂盒和方法
EP4323513A2 (de) * 2021-04-12 2024-02-21 Graphite Bio, Inc. Verfahren und zusammensetzungen zur herstellung genetisch modifizierter primärzellen
CN113755568B (zh) * 2021-08-26 2023-09-15 广东省妇幼保健院 利用微滴数字PCR检测α珠蛋白基因拷贝数的引物探针、试剂盒及应用
WO2023058100A1 (ja) * 2021-10-04 2023-04-13 国立大学法人 東京大学 構造多型の検出方法、プライマーセット及びプライマーセットの設計方法

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AU7855991A (en) * 1990-04-11 1991-10-30 United States of America, as represented by the Secretary, U.S. Department of Commerce, The A simple, rapid and reliable method for detecting thalassemia
US5374525A (en) * 1992-09-30 1994-12-20 University Of Utah Research Foundation Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension

Also Published As

Publication number Publication date
WO1997016568A1 (en) 1997-05-09
EP0859863B1 (de) 2003-06-18
EP0859863A1 (de) 1998-08-26
JP2000501923A (ja) 2000-02-22
US5750345A (en) 1998-05-12

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