DE69737293D1 - Nukleotidsequenz, die für eine flavinmonooxygenase kodiert, das korrespondierende protein, sowie deren verwendungen in diagnostik und therapie - Google Patents

Nukleotidsequenz, die für eine flavinmonooxygenase kodiert, das korrespondierende protein, sowie deren verwendungen in diagnostik und therapie

Info

Publication number
DE69737293D1
DE69737293D1 DE69737293T DE69737293T DE69737293D1 DE 69737293 D1 DE69737293 D1 DE 69737293D1 DE 69737293 T DE69737293 T DE 69737293T DE 69737293 T DE69737293 T DE 69737293T DE 69737293 D1 DE69737293 D1 DE 69737293D1
Authority
DE
Germany
Prior art keywords
flavinmono
oxygenase
diagnostics
therapy
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69737293T
Other languages
English (en)
Other versions
DE69737293T2 (de
Inventor
Marta Blumenfeld
Ilia Tchoumakov
Henri-Jean Garchon
Jean-Francois Bach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Merck Biodevelopment SAS
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Serono Genetics Institute SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Serono Genetics Institute SA filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Application granted granted Critical
Publication of DE69737293D1 publication Critical patent/DE69737293D1/de
Publication of DE69737293T2 publication Critical patent/DE69737293T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69737293T 1996-12-06 1997-12-05 Nukleotidsequenz, die für eine flavinmonooxygenase kodiert, das korrespondierende protein, sowie deren verwendungen in diagnostik und therapie Expired - Lifetime DE69737293T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9615032 1996-12-06
FR9615032A FR2756845B1 (fr) 1996-12-06 1996-12-06 Sequence nucleotidique codant pour une flavine monooxygenase , proteine correspondante et composition destinee au diagnostic et a la therapie du glaucome
PCT/FR1997/002226 WO1998024914A1 (fr) 1996-12-06 1997-12-05 Sequence nucleotidique codant pour une flavine mono-oxgynase, proteine correspondante et leurs applications dans les domaines du diagnostic et de la therapie

Publications (2)

Publication Number Publication Date
DE69737293D1 true DE69737293D1 (de) 2007-03-15
DE69737293T2 DE69737293T2 (de) 2007-06-21

Family

ID=9498426

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737293T Expired - Lifetime DE69737293T2 (de) 1996-12-06 1997-12-05 Nukleotidsequenz, die für eine flavinmonooxygenase kodiert, das korrespondierende protein, sowie deren verwendungen in diagnostik und therapie

Country Status (13)

Country Link
US (3) US6551792B1 (de)
EP (1) EP0941341B1 (de)
JP (1) JP4062638B2 (de)
AT (1) ATE352635T1 (de)
AU (1) AU746293B2 (de)
CA (1) CA2274011A1 (de)
CY (1) CY2605B2 (de)
DE (1) DE69737293T2 (de)
DK (1) DK0941341T3 (de)
ES (1) ES2279552T3 (de)
FR (1) FR2756845B1 (de)
PT (1) PT941341E (de)
WO (1) WO1998024914A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756845B1 (fr) 1996-12-06 1999-02-26 Genset Sa Sequence nucleotidique codant pour une flavine monooxygenase , proteine correspondante et composition destinee au diagnostic et a la therapie du glaucome
WO2001023603A2 (en) * 1999-09-30 2001-04-05 Mcgill University Human fmo3 gene mutations and polymorphisms, and uses thereof
US6902890B1 (en) 1999-11-04 2005-06-07 Diadexus, Inc. Method of diagnosing monitoring, staging, imaging and treating cancer
JP2002142765A (ja) * 2000-07-14 2002-05-21 Tosoh Corp 新規ゲノム解析法
US7214520B2 (en) 2000-07-18 2007-05-08 National Research Council Of Canada Cloning, sequencing and expression of a comamonas cyclopentanone 1,2-monooxygenase-encoding gene in Escherichia coli
EP1358353B1 (de) * 2000-12-28 2007-06-20 Epidauros Biotechnologie AG Identifizierung von genetischen determinanten der polymorphen cyp3a5 expression
WO2017044473A1 (en) 2015-09-11 2017-03-16 Novozymes Bioag A/S Stable inoculant compositions and methods for producing same
CN111973736B (zh) * 2020-08-17 2026-04-17 浙江大学 含黄素单氧化酶2在制备非酒精性脂肪肝病治疗药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4305696A1 (de) * 1993-02-25 1994-09-01 Hoechst Ag Nachweisverfahren zur Identifizierung von Inhibitoren
US5728676A (en) * 1994-09-08 1998-03-17 Ciba-Geigy Corporation Use of insulin-like growth factors I and II for inhibition of inflammatory response
JPH08140674A (ja) * 1994-11-18 1996-06-04 Sumitomo Chem Co Ltd ヒトフラビン含有モノオキシゲナーゼ
FR2756845B1 (fr) 1996-12-06 1999-02-26 Genset Sa Sequence nucleotidique codant pour une flavine monooxygenase , proteine correspondante et composition destinee au diagnostic et a la therapie du glaucome

Also Published As

Publication number Publication date
DK0941341T3 (da) 2007-03-19
AU5327198A (en) 1998-06-29
FR2756845A1 (fr) 1998-06-12
JP4062638B2 (ja) 2008-03-19
EP0941341A1 (de) 1999-09-15
EP0941341B1 (de) 2007-01-24
AU746293B2 (en) 2002-04-18
US7037709B2 (en) 2006-05-02
US20060154295A1 (en) 2006-07-13
CA2274011A1 (fr) 1998-06-11
JP2001505430A (ja) 2001-04-24
ES2279552T3 (es) 2007-08-16
DE69737293T2 (de) 2007-06-21
PT941341E (pt) 2007-02-28
US6551792B1 (en) 2003-04-22
FR2756845B1 (fr) 1999-02-26
WO1998024914A1 (fr) 1998-06-11
ATE352635T1 (de) 2007-02-15
US20030203463A1 (en) 2003-10-30
CY2605B2 (en) 2010-04-28

Similar Documents

Publication Publication Date Title
Todorov et al. Characterization of a cancer cachectic factor
DE3750094T2 (de) Klonierung und Expression einer Bordetella pertussis-Toxin-kodierenden DNS.
ATE182901T1 (de) Für androgen-rezeptor-protein kodierende dna
KR970701776A (ko) 형질전환 성장 인자 알파 에이치1(Transforming growth factor alpha H1)
DE69735375D1 (de) Genfamilie von apoptose-verwandten peptiden, dadurch kodierte peptide und verfahren zu deren herstellung
BR9712348A (pt) molécula de polinucleotídeo isolada, vetor de expressão, célula cultivada em que foi introduzido um vetor de expressão, processo para produzir um polipeptídeo homólogo de fgf, polipeptídeo homólogo de fgf isolado,composição farmacêutica, anticorpo, processos para estimular ex vivo células progenitoras de miócitos, e, paraliberar um agente ou droga seletivamente para o tecido do coração.
EP1484339A3 (de) Kallikreinhemmende "Kunitz-Domäne"Proteine dafür kodierende Nukleinsäure
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
TR199802252T2 (xx) N�ral ve renal geli�menin uyar�lmas� i�in ret ligand� (RetL)
ATE170192T1 (de) Zusammensetzungen und methoden zur synthese des b-rezeptors für das natriuretische protein und verwendungsmethoden
NZ279963A (en) Human tissue inhibitor of metalloproteinase-4 (timp-4) and dna (rna) encoding polypeptide which may be derived from atcc 75946
ATE106943T1 (de) Variante cd44-oberflächenproteine, diese kodierende dna-sequenzen, antikörper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie.
IS2819B (is) Viðloðunarsameindir í æðum og mótun á starfsemi@þeirra
DE69729954D1 (de) Identifizierungsverfahren für Substanzen die an das Pyk2 Polypeptid binden
DE69737293D1 (de) Nukleotidsequenz, die für eine flavinmonooxygenase kodiert, das korrespondierende protein, sowie deren verwendungen in diagnostik und therapie
ATE299182T1 (de) Polynukleotide und polypeptide aus pathogenen mycobakterien und deren verwendung als diagnostika, impfstoffe und als ziel der chemotherapie
NO982181L (no) Type IX collagen og chimerer
DE69128416T2 (de) Fibronektin bindendes Peptid
CA2099503A1 (en) Synthetic alpha-l-iduronidase and genetic sequences encoding same
OTAWARA et al. The NH2-terminal amino acid sequence of a y-carboxyglutamic acid-containing protein from rat femur cortical bone
EP1443055A3 (de) Interleukine-21 und 22
DE69433902D1 (de) Neuartige tyrosinkinase
DK0870036T3 (da) Syntetisk pattedyrs-alfa-N-acetylglucosaminidase og genetiske sekvenser kodende derfor
PT990000E (pt) Factor 3 de crescimento do tecido conjuntivo
NO962596L (no) Nytt tumorsupressorgen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition