PH17515A - Pyridazinone-substituted benzimidazoles and salts thereof - Google Patents

Pyridazinone-substituted benzimidazoles and salts thereof

Info

Publication number
PH17515A
PH17515A PH25674A PH25674A PH17515A PH 17515 A PH17515 A PH 17515A PH 25674 A PH25674 A PH 25674A PH 25674 A PH25674 A PH 25674A PH 17515 A PH17515 A PH 17515A
Authority
PH
Philippines
Prior art keywords
pyridazinone
salts
substituted benzimidazoles
benzimidazoles
substituted
Prior art date
Application number
PH25674A
Other languages
English (en)
Inventor
Volkhard Austel
Wolfgang Eberlein
Willi Diederen
Walter Haarmann
Joachim Heider
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782837161 external-priority patent/DE2837161A1/de
Priority claimed from DE19792922336 external-priority patent/DE2922336A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of PH17515A publication Critical patent/PH17515A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH25674A 1978-08-25 1981-05-26 Pyridazinone-substituted benzimidazoles and salts thereof PH17515A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung
DE19792922336 DE2922336A1 (de) 1979-06-01 1979-06-01 Neue in 5- oder 6-stellung durch einen pyridazinonring substituierte benzimidazole und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
PH17515A true PH17515A (en) 1984-09-13

Family

ID=25775527

Family Applications (1)

Application Number Title Priority Date Filing Date
PH25674A PH17515A (en) 1978-08-25 1981-05-26 Pyridazinone-substituted benzimidazoles and salts thereof

Country Status (17)

Country Link
US (1) US4361563A (fr)
EP (1) EP0008391B1 (fr)
AU (1) AU528825B2 (fr)
BG (1) BG60428B2 (fr)
CA (1) CA1134362A (fr)
CS (1) CS410191A3 (fr)
DE (1) DE2962051D1 (fr)
DK (1) DK152496C (fr)
ES (2) ES8101067A1 (fr)
FI (1) FI66372C (fr)
GR (1) GR69998B (fr)
HK (1) HK50585A (fr)
IE (1) IE48814B1 (fr)
MX (1) MX9202731A (fr)
NL (1) NL980035I2 (fr)
PH (1) PH17515A (fr)
SG (1) SG285G (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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US4699909A (en) * 1981-07-25 1987-10-13 Dr. Karl Thomae Gmbh Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
IL69027A (en) * 1982-06-21 1988-08-31 Wellcome Found Process for the production of interferon
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
US4717730A (en) * 1982-12-03 1988-01-05 Warner-Lambert Company 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components
US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
GB8320005D0 (en) * 1983-07-25 1983-08-24 Fujisawa Pharmaceutical Co Benzothiazoline derivatives
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
IL75122A (en) * 1984-05-14 1989-02-28 Lilly Co Eli 3-methyl-5-(tetrahydro-6-oxopyridazin-3-yl)indoline derivatives,their preparation and use
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
DE3505609A1 (de) * 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4725686A (en) * 1985-11-22 1988-02-16 William H. Rorer, Inc. Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE110071T1 (de) * 1988-01-23 1994-09-15 Kyowa Hakko Kogyo Kk Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5338743A (en) * 1988-06-06 1994-08-16 Fujisawa Pharmaceutical Co., Ltd. New use of the adenosine antagonist
EP0350990B1 (fr) * 1988-07-11 1995-09-20 Akzo Nobel N.V. Dérivés de pyridazinone
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3908531A1 (de) * 1989-03-16 1990-09-20 Thomae Gmbh Dr K Arzneimittel mit einer positiv inotropen wirkung, enthaltend eine synergistisch wirkende mischung, bestehend aus einem benzimidazol und einem ss-blocker, deren herstellung und deren verwendung
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5364646A (en) * 1990-01-10 1994-11-15 Dr. Karl Thomae Gmbh Oral pharmaceutical forms of pimobendan
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
DE69232323T2 (de) * 1991-01-29 2002-08-08 Fujisawa Pharmaceutical Co., Ltd. Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera
ATE246700T1 (de) * 1997-06-10 2003-08-15 Glaxo Group Ltd Benzimidazolderivate
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
DE69823240T2 (de) 1998-10-23 2005-04-28 Toray Industries, Inc. Immunmodulierende arzneimittelzusammenstellung
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
WO2002026078A2 (fr) * 2000-07-31 2002-04-04 Carl Ernest Alexander Dispositif et composition d'hygiene bucco-dentaire
EP1406621A2 (fr) * 2001-06-26 2004-04-14 Beth Israel Deaconess Medical Center Compositions et procedes prohibant l'activation plaquettaire et la thrombose
DE10203086A1 (de) * 2002-01-28 2003-07-31 Bayer Ag 5-Ring Heterozyklen
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (fr) * 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques
US8980894B2 (en) * 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
CN101282929A (zh) 2005-08-15 2008-10-08 Irm责任有限公司 用作tpo模拟物的化合物和组合物
WO2007054514A2 (fr) 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Utilisation d'inhibiteurs de la pde iii pour le traitement d'une insuffisance cardiaque asymptomatique (occulte)
EP1920785A1 (fr) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
ES2436716T3 (es) 2008-11-25 2014-01-03 Boehringer Ingelheim Vetmedica Gmbh Pimobendan para uso en el tratamiento de la cardiomiopatía hipertrófica en gatos
NL1037569C2 (en) * 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
JP2014521713A (ja) 2011-08-12 2014-08-28 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング 味をマスキングした医薬組成物
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106432095B (zh) * 2016-09-09 2019-04-16 东南大学 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备
CN106518850B (zh) * 2016-11-15 2019-04-09 青岛农业大学 一种匹莫苯丹的化学合成方法
WO2022073954A1 (fr) 2020-10-08 2022-04-14 Boehringer Ingelheim Vetmedica Gmbh Utilisation de pimobendan dans l'anesthésie de mammifères non humains
US20240197727A1 (en) 2022-12-15 2024-06-20 Boehringer Ingelheim Vetmedica Gmbh Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers
US20240308973A1 (en) * 2023-03-10 2024-09-19 Zoetis Services Llc Phosphodiesterase 3 (pde3) inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2516040C2 (de) * 1974-06-10 1984-12-20 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2427943C2 (de) * 1974-06-10 1984-08-02 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
JPS5416485A (en) * 1977-07-08 1979-02-07 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivatives and their preparation

Also Published As

Publication number Publication date
DK354279A (da) 1980-02-26
ES8105001A1 (es) 1981-05-16
FI792628A (fi) 1980-02-26
IE791629L (en) 1980-02-25
CS410191A3 (en) 1992-05-13
SG285G (en) 1985-11-15
MX9202731A (es) 1992-06-30
EP0008391B1 (fr) 1982-02-03
CA1134362A (fr) 1982-10-26
HK50585A (en) 1985-07-12
DK152496B (da) 1988-03-07
AU528825B2 (en) 1983-05-12
US4361563A (en) 1982-11-30
ES482789A0 (es) 1980-12-01
FI66372B (fi) 1984-06-29
ES491970A0 (es) 1981-05-16
IE48814B1 (en) 1985-05-29
AU5027979A (en) 1980-02-28
NL980035I1 (nl) 1999-02-01
DK152496C (da) 1988-07-25
DE2962051D1 (en) 1982-03-11
FI66372C (fi) 1984-10-10
BG60428B2 (bg) 1995-03-31
NL980035I2 (nl) 1999-03-01
GR69998B (fr) 1982-07-23
EP0008391A1 (fr) 1980-03-05
ES8101067A1 (es) 1980-12-01

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