PE20130204A1 - Formulacion farmaceutica en forma de comprimidos de dos capas que comprenden inhibidor de hmg-coa reductasa e irbesartan - Google Patents

Formulacion farmaceutica en forma de comprimidos de dos capas que comprenden inhibidor de hmg-coa reductasa e irbesartan

Info

Publication number
PE20130204A1
PE20130204A1 PE2012002144A PE2012002144A PE20130204A1 PE 20130204 A1 PE20130204 A1 PE 20130204A1 PE 2012002144 A PE2012002144 A PE 2012002144A PE 2012002144 A PE2012002144 A PE 2012002144A PE 20130204 A1 PE20130204 A1 PE 20130204A1
Authority
PE
Peru
Prior art keywords
irbesartan
hmg
coa reductase
reductase inhibitor
pharmaceutical formulation
Prior art date
Application number
PE2012002144A
Other languages
English (en)
Inventor
Yong Il Kim
Young Jun Na
Min Jung Kim
Young-Hun Kim
Jae Hyun Park
Jong Soo Woo
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45395310&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130204(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of PE20130204A1 publication Critical patent/PE20130204A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steering Devices For Bicycles And Motorcycles (AREA)

Abstract

SE REFIERE A UNA FORMULACION FARMACEUTICA QUE COMPRENDE UN COMPRIMIDO DE DOS FASES: a) UNA PRIMERA FASE QUE CONTIENE IRBESARTAN EN UNA CANTIDAD DE 8mg A 600mg POR FORMA DE DOSIFICACION UNITARIA; AGLUTINANTES TAL COMO ACIDO ALGINICO, POVIDONA, ENTRE OTROS; DESINTEGRANTES TAL COMO ALMIDON, METILCELULOSA, ENTRE OTROS; LUBRICANTES TAL COMO TALCO, ACEITE VEGETAL HIDROGENADO, ENTRE OTROS; AGENTES TENSIOACTIVOS TAL COMO LAURIL SULFATO DE SODIO, POLOXAMERO, ENTRE OTROS; b) UNA SEGUNDA FASE QUE CONTIENE UN INHIBIDOR DE HMG-CoA REDUCTASA TAL COMO ROSUVASTATINA, LOVASTATINA, ATORVASTATINA, ENTRE OTROS Y UN ADITIVO ALCALINO TAL COMO NaHCO3, CaCO3, MgCO3, ENTRE OTROS; ADEMAS COMPRENDE DILUYENTES SOLUBLES TAL COMO MANITOL, LACTOSA, ENTRE OTROS; DESINTEGRANTES, AGLUTINANTES, ENTRE OTROS. EL INHIBIDOR DE HMG-CoA ESTA PRESENTE EN UNA CANTIDAD DE 0,5 mg A 100mg POR FORMA DE DOSIFICACION UNITARIA; EL ADITIVO ALCALINO ESTA PRESENTE EN UNA CANTIDAD DE 2 A 10 PARTES EN PESO BASADO EN 1 PARTE DE INHIBIDOR DE HMG-CoA REDUCTASA Y EN UNA CANTIDAD DE 0,2 A 10 PARTES EN PESO BASADO EN 1 PARTE DE IRBESARTAN. DICHA FORMULACION TIENE UNA MEJORADA ESTABILIDAD Y VELOCIDAD DE DISOLUCION
PE2012002144A 2010-05-14 2011-05-13 Formulacion farmaceutica en forma de comprimidos de dos capas que comprenden inhibidor de hmg-coa reductasa e irbesartan PE20130204A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20100045636 2010-05-14
KR1020100053782A KR101248804B1 (ko) 2010-05-14 2010-06-08 ＨＭＧ-ＣｏＡ 환원효소 억제제 및 이베살탄을 포함하는 이층정 약제학적 복합제제

Publications (1)

Publication Number Publication Date
PE20130204A1 true PE20130204A1 (es) 2013-03-11

Family

ID=45395310

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2012002144A PE20130204A1 (es) 2010-05-14 2011-05-13 Formulacion farmaceutica en forma de comprimidos de dos capas que comprenden inhibidor de hmg-coa reductasa e irbesartan
PE2015002384A PE20151905A1 (es) 2010-05-14 2011-05-13 Formulacion farmaceutica en forma de comprimidos de dos capas que comprende inhibidor de hmg-coa reductasa e irbesartan

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2015002384A PE20151905A1 (es) 2010-05-14 2011-05-13 Formulacion farmaceutica en forma de comprimidos de dos capas que comprende inhibidor de hmg-coa reductasa e irbesartan

Country Status (36)

Country Link
US (1) US20130028974A1 (es)
EP (1) EP2568972B1 (es)
JP (1) JP5969466B2 (es)
KR (2) KR101248804B1 (es)
CN (1) CN103002883B (es)
AR (1) AR081032A1 (es)
AU (2) AU2011251085A1 (es)
BR (1) BR112012029064B8 (es)
CA (1) CA2798363C (es)
CL (1) CL2012003185A1 (es)
CO (1) CO6592025A2 (es)
CR (1) CR20120545A (es)
DK (1) DK2568972T3 (es)
DO (1) DOP2012000264A (es)
EA (1) EA023959B1 (es)
EC (1) ECSP12012224A (es)
ES (1) ES2645726T3 (es)
GT (1) GT201200309A (es)
HK (1) HK1181685A1 (es)
HU (1) HUE036638T2 (es)
IL (1) IL223012B (es)
JO (1) JO3409B1 (es)
MA (1) MA34313B1 (es)
MX (1) MX342868B (es)
MY (1) MY157307A (es)
NI (1) NI201200170A (es)
NZ (1) NZ604402A (es)
PE (2) PE20130204A1 (es)
PL (1) PL2568972T3 (es)
PT (1) PT2568972T (es)
SG (1) SG185778A1 (es)
SI (1) SI2568972T1 (es)
TW (1) TW201200166A (es)
UA (1) UA107967C2 (es)
WO (1) WO2011142621A2 (es)
ZA (1) ZA201209481B (es)

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CN103356500A (zh) * 2012-03-30 2013-10-23 肖广常 一种瑞舒伐他汀钙非诺贝特酸胆碱盐择时渗透泵控释片及其制备方法
BR102012020648A2 (pt) * 2012-08-17 2014-12-09 Hypermarcas S A Preparação farmacêutica oral sólida para a prevenção de doença cardio e cerebrovasculares e comprimido
KR20140028971A (ko) 2012-08-31 2014-03-10 한미약품 주식회사 아토바스타틴, 이르베살탄 및 탄산마그네슘을 포함하는 이층정 복합제제
KR20140030505A (ko) * 2012-08-31 2014-03-12 한미약품 주식회사 이베살탄 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 약제학적 캡슐 복합제제
CA2905686C (en) * 2013-03-14 2017-06-27 Boryung Pharmaceutical Co., Ltd. Pharmaceutical combination drug
KR101597004B1 (ko) * 2013-07-25 2016-02-23 씨제이헬스케어 주식회사 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제
KR20150079373A (ko) * 2013-12-30 2015-07-08 한미약품 주식회사 에제티미브 및 로수바스타틴을 포함하는 경구용 복합제제
KR101771766B1 (ko) * 2013-12-30 2017-08-28 알보젠코리아 주식회사 안지오텐신-Ⅱ 수용체 차단제 및 HMG-CoA 환원효소 저해제를 포함하는 약제학적 복합제제
CN105769793A (zh) * 2016-04-04 2016-07-20 孙爱华 一种辛伐他汀片剂及其制备方法
MX2021007734A (es) * 2018-12-31 2021-08-05 Boryung Pharm Comprimido y metodo de preparacion del mismo.
KR102042626B1 (ko) * 2019-06-26 2019-11-11 한미약품 주식회사 이베살탄 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 약제학적 캡슐 복합제제
WO2022260439A1 (ko) * 2021-06-09 2022-12-15 주식회사 보령 약학적 복합 제제 및 제조 방법

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KR20090114190A (ko) * 2008-04-29 2009-11-03 한올제약주식회사 방출성이 제어된 ＨＭＧ―ＣｏＡ 환원 효소 억제제와안지오텐신―Ⅱ―수용체 차단제의 복합 조성물
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Also Published As

Publication number Publication date
ECSP12012224A (es) 2012-11-30
KR20110126020A (ko) 2011-11-22
KR20130024940A (ko) 2013-03-08
EP2568972A2 (en) 2013-03-20
HK1181685A1 (zh) 2013-11-15
MX342868B (es) 2016-10-17
CA2798363A1 (en) 2011-11-17
SG185778A1 (en) 2013-01-30
IL223012B (en) 2019-03-31
PL2568972T3 (pl) 2017-12-29
PT2568972T (pt) 2017-10-09
ZA201209481B (en) 2014-02-26
MA34313B1 (fr) 2013-06-01
CR20120545A (es) 2012-12-06
AU2011251085A1 (en) 2013-01-10
WO2011142621A2 (en) 2011-11-17
CA2798363C (en) 2018-06-05
CL2012003185A1 (es) 2013-02-22
AU2016203739B2 (en) 2017-11-02
BR112012029064B8 (pt) 2020-08-11
DK2568972T3 (da) 2017-11-06
KR101248804B1 (ko) 2013-03-29
BR112012029064B1 (pt) 2019-10-22
SI2568972T1 (sl) 2017-10-30
NZ604402A (en) 2015-02-27
EA023959B1 (ru) 2016-07-29
WO2011142621A3 (en) 2012-03-08
US20130028974A1 (en) 2013-01-31
JO3409B1 (ar) 2019-10-20
EP2568972A4 (en) 2014-07-02
CO6592025A2 (es) 2013-01-02
AU2016203739A1 (en) 2016-06-23
EA201291247A1 (ru) 2013-04-30
CN103002883A (zh) 2013-03-27
EP2568972B1 (en) 2017-08-02
PE20151905A1 (es) 2016-01-07
AR081032A1 (es) 2012-05-30
TW201200166A (en) 2012-01-01
JP5969466B2 (ja) 2016-08-17
HUE036638T2 (hu) 2018-07-30
JP2013526516A (ja) 2013-06-24
MX2012013175A (es) 2013-01-17
CN103002883B (zh) 2015-08-26
DOP2012000264A (es) 2012-11-30
MY157307A (en) 2016-05-31
UA107967C2 (en) 2015-03-10
IL223012A0 (en) 2013-02-03
NI201200170A (es) 2013-05-29
GT201200309A (es) 2014-03-14
ES2645726T3 (es) 2017-12-07
BR112012029064A2 (pt) 2016-08-09

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