PE20040942A1 - Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantes - Google Patents
Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantesInfo
- Publication number
- PE20040942A1 PE20040942A1 PE2004000100A PE2004000100A PE20040942A1 PE 20040942 A1 PE20040942 A1 PE 20040942A1 PE 2004000100 A PE2004000100 A PE 2004000100A PE 2004000100 A PE2004000100 A PE 2004000100A PE 20040942 A1 PE20040942 A1 PE 20040942A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- remielinating
- aryl
- antibody
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 206010033799 Paralysis Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 108010072051 Glatiramer Acetate Proteins 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- SBBWEQLNKVHYCX-JTQLQIEISA-N ethyl L-tyrosinate Chemical compound CCOC(=O)[C@@H](N)CC1=CC=C(O)C=C1 SBBWEQLNKVHYCX-JTQLQIEISA-N 0.000 abstract 1
- 229960003776 glatiramer acetate Drugs 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960005027 natalizumab Drugs 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44217103P | 2003-01-24 | 2003-01-24 | |
| US50031603P | 2003-09-05 | 2003-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040942A1 true PE20040942A1 (es) | 2004-12-28 |
Family
ID=32829779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000100A PE20040942A1 (es) | 2003-01-24 | 2004-01-26 | Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantes |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20050069541A1 (enExample) |
| EP (4) | EP3527228A1 (enExample) |
| JP (4) | JP2006516624A (enExample) |
| KR (2) | KR20050114212A (enExample) |
| AU (5) | AU2004207535A1 (enExample) |
| CA (2) | CA2514125A1 (enExample) |
| CO (1) | CO5670359A2 (enExample) |
| IL (1) | IL169770A (enExample) |
| MX (2) | MXPA05007843A (enExample) |
| NO (1) | NO20053920L (enExample) |
| PE (1) | PE20040942A1 (enExample) |
| RU (1) | RU2412721C2 (enExample) |
| SK (1) | SK50642005A3 (enExample) |
| TW (2) | TW201311238A (enExample) |
| UY (1) | UY28170A1 (enExample) |
| WO (2) | WO2004066932A2 (enExample) |
Families Citing this family (45)
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| US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
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| KR20050114212A (ko) | 2003-01-24 | 2005-12-05 | 엘란 파마슈티칼스, 인크. | 수초재생제의 투여에 의한 탈수초성 질환 및 마비의 치료및 조성물 |
| EP1706399A1 (en) | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
| MY162179A (en) | 2004-04-01 | 2017-05-31 | Elan Pharm Inc | Steroid sparing agents and methods of using same |
| AR050425A1 (es) * | 2004-07-08 | 2006-10-25 | Elan Pharm Inc | Antagonistas multivalentes de vla-4 que comprende fracciones polimericas. composiciones farmaceuticas |
| CA2478458A1 (en) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
| JP2008520717A (ja) * | 2004-11-19 | 2008-06-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 多発性硬化症についての処置 |
| NZ581497A (en) * | 2004-12-03 | 2012-07-27 | Biogen Idec Inc | Delaying or preventing onset of multiple sclerosis by vla-4 ginding antibody |
| PL1874821T3 (pl) | 2005-04-26 | 2013-09-30 | Trion Pharma Gmbh | Kombinacja przeciwciał i glikokortykoidów do leczenia raka |
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| US8030328B2 (en) | 2005-05-20 | 2011-10-04 | Elan Pharmaceuticals, Inc. | Imidazolone phenylalanine derivatives |
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| CA2667944A1 (en) * | 2005-10-26 | 2007-05-03 | Medivas, Llc | Aromatic di-acid-containing poly (ester amide) polymers and methods of use |
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| US9008378B2 (en) | 2006-12-20 | 2015-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | Arrangement and imaging of biological samples |
| EP2198040B1 (en) * | 2007-08-31 | 2018-08-15 | Case Western Reserve University | In vivo imaging of myelin |
| AU2009298888A1 (en) * | 2008-09-23 | 2010-04-08 | Georgetown University | 1,2-benzisothiazolinone and isoindolinone derivatives |
| SG175166A1 (en) * | 2009-04-17 | 2011-11-28 | Biogen Idec Inc | Compositions and methods to treat acute myelogenous leukemia |
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| PT2558499T (pt) | 2010-04-16 | 2017-07-14 | Biogen Ma Inc | Anticorpos anti-vla-4 |
| WO2012012147A2 (en) * | 2010-06-30 | 2012-01-26 | Victoria Link Ltd | Methods and compositions for treatment of multiple sclerosis |
| JP5847188B2 (ja) | 2010-10-25 | 2016-01-20 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | ｓＶＣＡＭおよび／またはｓＭＡｄＣＡＭレベルの差を関連付けることにより、アルファ−４インテグリン活性の差を決定するための方法 |
| AR084141A1 (es) * | 2010-11-19 | 2013-04-24 | Imai Toshio | Anticuerpos neutralizadores anti-ccl20 |
| US9428472B2 (en) | 2011-08-16 | 2016-08-30 | Georgetown University | Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives |
| PT3590960T (pt) | 2012-02-29 | 2023-04-18 | Takeda Pharmaceuticals Co | Remielinização estimulada por igg de nervos periféricos |
| TWI660972B (zh) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
| HK1213794A1 (zh) * | 2012-10-09 | 2016-07-15 | Biogen Ma Inc. | 联合治疗及用於治疗脱髓鞘病症的用途 |
| AU2014324426A1 (en) | 2013-09-30 | 2016-04-21 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| CA2938933A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
| ES2744526T3 (es) | 2014-03-12 | 2020-02-25 | Prothena Biosciences Ltd | Anticuerpos anti-MCAM y métodos de uso asociados |
| KR20170052526A (ko) * | 2014-03-13 | 2017-05-12 | 프로테나 바이오사이언시즈 리미티드 | 다발성 경화증에 대한 병용 치료 |
| KR102364840B1 (ko) | 2014-11-05 | 2022-02-18 | 삼성전자주식회사 | 신경세포의 탈수초화와 연관된 질환을 치료하기 위한 약학적 조성물 및 그를 이용하는 방법 |
| EP3229797A4 (en) * | 2014-12-12 | 2018-08-15 | Commonwealth Scientific and Industrial Research Organisation | Dislodgement and release of hsc from the bone marrow stem cell niche using alpha9 integrin antagonists |
| US10738121B2 (en) | 2015-02-27 | 2020-08-11 | The General Hospital Corporation | Therapeutic use of integrin-binding antibodies |
| WO2016145258A1 (en) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| CN106316982B (zh) | 2015-06-30 | 2020-08-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻嗪酰胺衍生物及其用途 |
| US10947311B2 (en) * | 2015-11-20 | 2021-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | VCAM-1 mediated methods and compositions for treating aging-associated impairments |
| AU2019274649B2 (en) * | 2018-05-23 | 2025-10-09 | Csl Behring Ag | Treatment of CIDP |
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| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| DK3873884T3 (da) | 2018-10-30 | 2025-02-17 | Gilead Sciences Inc | 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme |
| PL3873605T3 (pl) | 2018-10-30 | 2025-03-03 | Gilead Sciences, Inc. | Związki hamujące integrynę alfa4beta7 |
| EP3873897B1 (en) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
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2004
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- 2004-01-26 EP EP19152970.0A patent/EP3527228A1/en not_active Withdrawn
- 2004-01-26 RU RU2005126728/15A patent/RU2412721C2/ru active
- 2004-01-26 EP EP04705266A patent/EP1592386A4/en not_active Withdrawn
- 2004-01-26 PE PE2004000100A patent/PE20040942A1/es not_active Application Discontinuation
- 2004-01-26 CA CA002514125A patent/CA2514125A1/en not_active Abandoned
- 2004-01-26 UY UY28170A patent/UY28170A1/es not_active Application Discontinuation
- 2004-01-26 KR KR1020127024847A patent/KR101260497B1/ko not_active Expired - Lifetime
- 2004-01-26 JP JP2006502997A patent/JP2006516624A/ja active Pending
- 2004-01-26 EP EP04705270A patent/EP1592387A4/en not_active Withdrawn
- 2004-01-26 MX MXPA05007843A patent/MXPA05007843A/es unknown
- 2004-01-26 US US10/763,424 patent/US20050069541A1/en not_active Abandoned
- 2004-01-26 AU AU2004207535A patent/AU2004207535A1/en not_active Abandoned
- 2004-01-26 CA CA002514117A patent/CA2514117A1/en not_active Abandoned
- 2004-01-26 EP EP11008463A patent/EP2484381A1/en not_active Withdrawn
- 2004-01-26 US US10/763,539 patent/US7576101B2/en active Active
- 2004-01-26 JP JP2006503001A patent/JP2007521249A/ja active Pending
- 2004-01-26 WO PCT/US2004/002039 patent/WO2004066932A2/en not_active Ceased
- 2004-01-26 WO PCT/US2004/002028 patent/WO2004066931A2/en not_active Ceased
- 2004-01-26 MX MXPA05007823A patent/MXPA05007823A/es not_active Application Discontinuation
- 2004-01-26 SK SK5064-2005A patent/SK50642005A3/sk not_active Application Discontinuation
- 2004-01-26 AU AU2004207536A patent/AU2004207536B2/en not_active Expired - Fee Related
- 2004-01-27 TW TW101146999A patent/TW201311238A/zh unknown
- 2004-01-27 TW TW093101747A patent/TWI428141B/zh not_active IP Right Cessation
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2005
- 2005-07-19 IL IL169770A patent/IL169770A/en active IP Right Grant
- 2005-08-23 NO NO20053920A patent/NO20053920L/no not_active Application Discontinuation
- 2005-08-24 CO CO05084319A patent/CO5670359A2/es not_active Application Discontinuation
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2010
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- 2010-08-19 AU AU2010212446A patent/AU2010212446B2/en not_active Expired
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