PE20030907A1 - Terapias de combinacion para tratar celulas deficientes en metiltioadenosina-fosforilasa - Google Patents
Terapias de combinacion para tratar celulas deficientes en metiltioadenosina-fosforilasaInfo
- Publication number
- PE20030907A1 PE20030907A1 PE2003000205A PE2003000205A PE20030907A1 PE 20030907 A1 PE20030907 A1 PE 20030907A1 PE 2003000205 A PE2003000205 A PE 2003000205A PE 2003000205 A PE2003000205 A PE 2003000205A PE 20030907 A1 PE20030907 A1 PE 20030907A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formyl
- amino
- transferase
- methyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
SE REFIERE A UN METODO PARA DESTRUIR CELULAS DEFICIENTES EN METILTIOADENOSINA-FOSFORILASA (MTAP) QUE COMPRENDE ADMINISTRAR a)INHIBIDOR DE GLICINAMIDA-RIBONUCLEOTIDO-FORMILTRANSFERASA, AMINOIMIDAZOLCARBOXIMIDA-RIBONUCLEOTIDO-FORMILTRANSFERASA DE FORMULA A (ACIDO N-(5-[2-(2-AMINO-4(3H)-OXO-5,6,7,8-TETRAHIDROPIRIDO[2,3-d]-PIRIMIDIN-6-IL)-(R)-ETIL]-4-METILTIENO-2-IL)-L-GLUTAMICO, O UN COMPUESTO OXOPIRIDO DE FORMULA II; A ES S, Se; GRUPO ES UN INTERCALADOR NO CICLICO; ANILLO ES CICLOALQUILO, HETEROCICLOALQUILO, ARILO, HETEROARILO; R1 Y R2 SON H, ALQUILO, GRUPO HIDROLIZABLE; R3 ES H, ALQUILO, CICLOALQUILO; b)UN AGENTE ANTITOXICO (ANALOGO DE METILADENOSINA FOSFORILASA) EN UNA CANTIDAD PARA INCREMENTAR LA DOSIS TOLERADA MAXIMA DEL INHIBIDOR DE FORMULA X; DONDE R41 ES Rg, RgYRhRi, CONRjRk, COORh; Rg ES ALQUILO, ALQUENILENO, ALQUINILENO; Y ES O, NH, S, METILENO; Rh, Ri SON H, ALQUILO, ALQUENILO, ALQUINILO; Rj Y Rk SON H, ALQUILO, AMINO, HALOALQUILO, ENTRE OTROS; SON COMPUESTOS PREFERIDOS (2S,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-IL)-4-(METILTIO)-2-[(METIL-TIO)METIL]TETRAHIDROFURAN-3-OL; (2S,3S,4R,5R)-2-(6-AMINO-9H-PURIN-9-IL)-5-{[(4-CLOROBENCIL)TIO]-METIL}-TETRAHIDROFURAN-3,4-DIOL, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36164502P | 2002-03-04 | 2002-03-04 | |
US43227502P | 2002-12-09 | 2002-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030907A1 true PE20030907A1 (es) | 2003-10-29 |
Family
ID=27791683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000205A PE20030907A1 (es) | 2002-03-04 | 2003-02-28 | Terapias de combinacion para tratar celulas deficientes en metiltioadenosina-fosforilasa |
Country Status (14)
Country | Link |
---|---|
US (1) | US20040043959A1 (es) |
EP (1) | EP1482977A1 (es) |
KR (1) | KR20040091089A (es) |
AR (1) | AR038863A1 (es) |
AU (1) | AU2003206019A1 (es) |
BR (1) | BR0308222A (es) |
CA (1) | CA2477422A1 (es) |
IL (1) | IL163776A0 (es) |
NO (1) | NO20044191L (es) |
PA (1) | PA8568201A1 (es) |
PE (1) | PE20030907A1 (es) |
TW (1) | TW200304380A (es) |
UY (1) | UY27692A1 (es) |
WO (1) | WO2003074083A1 (es) |
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WO2004113328A1 (en) * | 2003-06-25 | 2004-12-29 | Pfizer Inc. | Convergent asymmetric synthesis route to produce a key intermediate towards the synthesis of a garft inhibitor |
JP2005292087A (ja) * | 2004-04-05 | 2005-10-20 | Shionogi & Co Ltd | 5’−デオキシ−5’−メチルチオアデノシンに対する抗体 |
US7981902B2 (en) * | 2006-06-28 | 2011-07-19 | Duquesne University Of The Holy Ghost | Substituted pyrrolo[2,3-d]pyrimidines for selectively targeting tumor cells with FR type receptors |
WO2009032057A2 (en) * | 2007-08-29 | 2009-03-12 | Adam Lubin | Method for the selective therapy of disease |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
MX2010007418A (es) | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
JP5789252B2 (ja) * | 2009-05-07 | 2015-10-07 | インテリカイン, エルエルシー | 複素環式化合物およびその使用 |
US9725479B2 (en) * | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
US8604032B2 (en) | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
EP2637669A4 (en) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and their use |
AU2011336415B2 (en) | 2010-12-03 | 2016-08-11 | Epizyme, Inc. | Substituted purine and 7 - deazapurine compounds as modulators of epigenetic enzymes |
WO2012075500A2 (en) | 2010-12-03 | 2012-06-07 | Epizyme, Inc. | 7-deazapurine modulators of histone methyltransferase, and methods of use thereof |
CN103648499B (zh) | 2011-01-10 | 2017-02-15 | 无限药品股份有限公司 | 用于制备异喹啉酮的方法及异喹啉酮的固体形式 |
CN103930422A (zh) | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
AU2012284091B2 (en) | 2011-07-19 | 2015-11-12 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
CN103998442B (zh) | 2011-08-29 | 2016-09-14 | 无限药品股份有限公司 | 杂环化合物及其用途 |
EP2771012A4 (en) * | 2011-10-24 | 2015-06-24 | Glaxosmithkline Ip No 2 Ltd | NEW CONNECTIONS |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
EP2882750A4 (en) | 2012-08-10 | 2016-08-17 | Epizyme Inc | INHIBITORS OF THE PROTEIN METHYLTRANSFERASE DOT1L AND METHOD OF USE THEREOF |
US9597348B2 (en) | 2012-09-06 | 2017-03-21 | Epizyme, Inc. | Method of treating leukemia |
CN103073606B (zh) * | 2013-02-05 | 2016-05-18 | 中国医药研究开发中心有限公司 | 5’-s-(4,4’-二甲氧基三苯甲基)-2’-脱氧肌苷的合成与制备方法 |
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MX2021012208A (es) | 2013-10-04 | 2023-01-19 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos. |
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CA2943075C (en) | 2014-03-19 | 2023-02-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
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MA39986A (fr) | 2014-04-25 | 2017-03-01 | Vitae Pharmaceuticals Inc | Dérivés de purine en tant qu'inhibiteurs de cd73 pour le traitement du cancer |
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JPWO2016056606A1 (ja) * | 2014-10-07 | 2017-07-20 | 国立大学法人京都大学 | ベンゾイソチアゾロピリミジン誘導体またはその塩、およびウイルス感染阻害剤ならびに医薬品 |
TW202321249A (zh) | 2015-08-26 | 2023-06-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
US10160761B2 (en) | 2015-09-14 | 2018-12-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
EA201892031A1 (ru) | 2016-03-10 | 2019-02-28 | Янссен Фармацевтика Нв | Замещенные аналоги нуклеозидов для применения в качестве ингибиторов prmt5 |
CN108884108B (zh) * | 2016-03-10 | 2021-08-31 | 詹森药业有限公司 | 用于用作prmt5抑制剂的取代核苷类似物 |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
CA2969295A1 (en) * | 2016-06-06 | 2017-12-06 | Pfizer Inc. | Substituted carbonucleoside derivatives, and use thereof as a prmt5 inhibitor |
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JP7054681B2 (ja) | 2016-06-24 | 2022-04-14 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 組合せ療法 |
MX2019002962A (es) | 2016-09-14 | 2019-07-04 | Janssen Pharmaceutica Nv | Inhibidores espirobiciclicos de la interaccion de menina-mll. |
BR112019004764A2 (pt) | 2016-09-14 | 2019-05-28 | Janssen Pharmaceutica Nv | inibidores bicíclicos fundidos da interação menina-mll |
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EA201990851A1 (ru) | 2017-02-24 | 2019-09-30 | Янссен Фармацевтика Нв | Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5 |
JP7225106B2 (ja) | 2017-02-27 | 2023-02-20 | ヤンセン ファーマシューティカ エヌ.ベー. | Prmt5阻害剤による治療に応答する癌患者の同定におけるバイオマーカーの使用 |
CA3084449A1 (en) | 2017-12-08 | 2019-06-13 | Janssen Pharmaceutica Nv | Novel spirobicyclic analogues |
US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
CN109111445B (zh) * | 2018-11-02 | 2020-12-18 | 哈尔滨商业大学 | 5’-呋喃甲酰酯-3’-脱氧腺苷的合成方法及应用 |
CN109369758B (zh) * | 2018-11-02 | 2021-04-13 | 哈尔滨商业大学 | 5′-(6-氯烟酰酯)-3′-脱氧腺苷的合成方法及其应用 |
EP3939988A4 (en) * | 2019-03-20 | 2022-08-24 | Korea Research Institute of Chemical Technology | PHARMACEUTICAL COMPOSITION WITH NOVEL HETEROCYCLIC AZOLOPYRIMIDINE COMPOUND AS THE ACTIVE SUBSTANCE |
TW202112375A (zh) | 2019-06-06 | 2021-04-01 | 比利時商健生藥品公司 | 使用prmt5抑制劑治療癌症之方法 |
WO2020249663A1 (en) | 2019-06-12 | 2020-12-17 | Janssen Pharmaceutica Nv | Novel spirobicyclic intermediates |
WO2021254529A1 (zh) * | 2020-07-14 | 2021-12-23 | 江苏先声药业有限公司 | 双环类化合物 |
LV15670B (lv) * | 2021-03-10 | 2023-11-20 | Latvijas Organiskās Sintēzes Institūts | Jauni adenozilmerkaptāna atvasinājumi kā vīrusu m-RNS kapinga metiltransferāžu inhibitori |
EP4326273A1 (en) * | 2021-04-19 | 2024-02-28 | Emory University | Quinazoline derivatives, pharmaceutical compositions, and therapeutic uses related to nox inhibition |
CN113603721B (zh) * | 2021-06-21 | 2023-12-01 | 重庆文理学院 | 一种合成saicar的方法 |
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US5840505A (en) * | 1993-12-29 | 1998-11-24 | The Regents Of The University Of California | Method for inhibiting adenylosuccinate synthetase activity in methylthioadenosine phosphorylase deficient cells |
US5942393A (en) * | 1993-12-29 | 1999-08-24 | The Regents Of The University Of California | Method for the detection of the presence or absence of methylthioadenosine phosphorylase (MTASE) in a cell sample by detection of the presence or absence of MTASE encoding nucleic acid in the cell sample |
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US5608082A (en) * | 1994-07-28 | 1997-03-04 | Agouron Pharmaceuticals, Inc. | Compounds useful as antiproliferative agents and GARFT inhibitors |
-
2003
- 2003-02-14 US US10/367,366 patent/US20040043959A1/en not_active Abandoned
- 2003-02-17 CA CA002477422A patent/CA2477422A1/en not_active Abandoned
- 2003-02-17 WO PCT/IB2003/000615 patent/WO2003074083A1/en not_active Application Discontinuation
- 2003-02-17 IL IL17377603A patent/IL163776A0/xx unknown
- 2003-02-17 EP EP03702902A patent/EP1482977A1/en not_active Withdrawn
- 2003-02-17 BR BR0308222-9A patent/BR0308222A/pt not_active Application Discontinuation
- 2003-02-17 KR KR10-2004-7013707A patent/KR20040091089A/ko not_active Application Discontinuation
- 2003-02-17 AU AU2003206019A patent/AU2003206019A1/en not_active Abandoned
- 2003-02-28 PA PA20038568201A patent/PA8568201A1/es unknown
- 2003-02-28 UY UY27692A patent/UY27692A1/es not_active Application Discontinuation
- 2003-02-28 PE PE2003000205A patent/PE20030907A1/es not_active Application Discontinuation
- 2003-03-03 TW TW092104399A patent/TW200304380A/zh unknown
- 2003-03-03 AR ARP030100700A patent/AR038863A1/es not_active Application Discontinuation
-
2004
- 2004-09-30 NO NO20044191A patent/NO20044191L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20040043959A1 (en) | 2004-03-04 |
NO20044191L (no) | 2004-09-30 |
CA2477422A1 (en) | 2003-09-12 |
UY27692A1 (es) | 2003-10-31 |
WO2003074083A1 (en) | 2003-09-12 |
EP1482977A1 (en) | 2004-12-08 |
AR038863A1 (es) | 2005-02-02 |
KR20040091089A (ko) | 2004-10-27 |
BR0308222A (pt) | 2005-02-09 |
IL163776A0 (en) | 2005-12-18 |
AU2003206019A1 (en) | 2003-09-16 |
PA8568201A1 (es) | 2003-11-12 |
TW200304380A (en) | 2003-10-01 |
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