MX2019003843A - Análogos novedosos de carbanucleósidos sustituidos de sistema anular monocíclico y bicíclico para su uso como inhibidores de prmt5. - Google Patents
Análogos novedosos de carbanucleósidos sustituidos de sistema anular monocíclico y bicíclico para su uso como inhibidores de prmt5.Info
- Publication number
- MX2019003843A MX2019003843A MX2019003843A MX2019003843A MX2019003843A MX 2019003843 A MX2019003843 A MX 2019003843A MX 2019003843 A MX2019003843 A MX 2019003843A MX 2019003843 A MX2019003843 A MX 2019003843A MX 2019003843 A MX2019003843 A MX 2019003843A
- Authority
- MX
- Mexico
- Prior art keywords
- ring system
- bicyclic ring
- system substituted
- prmt5 inhibitors
- novel
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 125000002950 monocyclic group Chemical group 0.000 title abstract 2
- 101150097768 prmt5 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100034607 Protein arginine N-methyltransferase 5 Human genes 0.000 abstract 1
- 101710084427 Protein arginine N-methyltransferase 5 Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a análogos novedosos novedosos de carbanucleosidos sustituidos de sistema anular monociclico y biciclico de Formula (I) ver figura..... donde las variables tienen el significado definido en las reivindicaciones; los compuestos de acuerdo con la presente invención son útiles como inhibidores PRMT5; la invención se refiere además a composiciones farmacéuticas que comprenden dichos compuestos como principio activo, así como al uso de dichos compuestos como medicamento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662403336P | 2016-10-03 | 2016-10-03 | |
EP17157785 | 2017-02-24 | ||
PCT/EP2017/074983 WO2018065365A1 (en) | 2016-10-03 | 2017-10-02 | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019003843A true MX2019003843A (es) | 2019-06-24 |
Family
ID=60043171
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019003843A MX2019003843A (es) | 2016-10-03 | 2017-10-02 | Análogos novedosos de carbanucleósidos sustituidos de sistema anular monocíclico y bicíclico para su uso como inhibidores de prmt5. |
MX2023005574A MX2023005574A (es) | 2016-10-03 | 2019-04-02 | Analogos novedosos de carbanucleosidos sustituidos de sistema anular monociclico y biciclico para su uso como inhibidores de prmt5. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023005574A MX2023005574A (es) | 2016-10-03 | 2019-04-02 | Analogos novedosos de carbanucleosidos sustituidos de sistema anular monociclico y biciclico para su uso como inhibidores de prmt5. |
Country Status (15)
Country | Link |
---|---|
US (3) | US11098062B2 (es) |
EP (1) | EP3519413A1 (es) |
JP (2) | JP7101171B2 (es) |
KR (1) | KR102531344B1 (es) |
CN (2) | CN109803971B (es) |
AU (1) | AU2017338269B2 (es) |
BR (1) | BR112019006414A2 (es) |
CA (1) | CA3037998A1 (es) |
IL (1) | IL265718B (es) |
MA (1) | MA46341A (es) |
MX (2) | MX2019003843A (es) |
PE (1) | PE20190706A1 (es) |
PH (1) | PH12019500731A1 (es) |
TN (1) | TN2019000087A1 (es) |
UA (1) | UA124074C2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202321249A (zh) * | 2015-08-26 | 2023-06-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
PE20190706A1 (es) | 2016-10-03 | 2019-05-17 | Janssen Pharmaceutica Nv | Analogos novedosos de carbanucleosidos sustituidos de sistema anular monociclico y bicicilo para su uso como inhibidores de prmt5 |
WO2019110734A1 (en) | 2017-12-08 | 2019-06-13 | Janssen Pharmaceutica Nv | Novel spirobicyclic analogues |
WO2019219805A1 (en) * | 2018-05-16 | 2019-11-21 | Ctxone Pty Ltd | Combination therapy |
TW202112375A (zh) | 2019-06-06 | 2021-04-01 | 比利時商健生藥品公司 | 使用prmt5抑制劑治療癌症之方法 |
CN113186153B (zh) * | 2021-04-15 | 2023-09-08 | 南方医科大学 | Prmt5抑制剂在促进精原干细胞损伤再生和增殖中的应用 |
CN113234079B (zh) * | 2021-04-30 | 2022-02-01 | 上海湃隆生物科技有限公司 | 用作prmt5抑制剂的核苷类似物 |
CN114740108B (zh) * | 2022-03-28 | 2023-07-14 | 天津键凯科技有限公司 | 一种聚合物修饰抗体类药物的修饰度的测定方法 |
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TW202321249A (zh) | 2015-08-26 | 2023-06-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
CN108884108B (zh) | 2016-03-10 | 2021-08-31 | 詹森药业有限公司 | 用于用作prmt5抑制剂的取代核苷类似物 |
PE20190706A1 (es) | 2016-10-03 | 2019-05-17 | Janssen Pharmaceutica Nv | Analogos novedosos de carbanucleosidos sustituidos de sistema anular monociclico y bicicilo para su uso como inhibidores de prmt5 |
EA201990851A1 (ru) | 2017-02-24 | 2019-09-30 | Янссен Фармацевтика Нв | Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5 |
EA201992026A1 (ru) | 2017-02-27 | 2020-01-24 | Янссен Фармацевтика Нв | Применение биомаркеров при идентификации пациентов, имеющих рак, которые будут характеризоваться наличием восприимчивости к лечению ингибитором prmt5 |
WO2019110734A1 (en) | 2017-12-08 | 2019-06-13 | Janssen Pharmaceutica Nv | Novel spirobicyclic analogues |
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2017
- 2017-10-02 PE PE2019000723A patent/PE20190706A1/es unknown
- 2017-10-02 AU AU2017338269A patent/AU2017338269B2/en active Active
- 2017-10-02 BR BR112019006414A patent/BR112019006414A2/pt unknown
- 2017-10-02 UA UAA201904546A patent/UA124074C2/uk unknown
- 2017-10-02 MX MX2019003843A patent/MX2019003843A/es unknown
- 2017-10-02 MA MA046341A patent/MA46341A/fr unknown
- 2017-10-02 JP JP2019517909A patent/JP7101171B2/ja active Active
- 2017-10-02 CN CN201780061258.4A patent/CN109803971B/zh active Active
- 2017-10-02 CN CN202211277466.7A patent/CN115626935A/zh active Pending
- 2017-10-02 US US16/336,934 patent/US11098062B2/en active Active
- 2017-10-02 TN TNP/2019/000087A patent/TN2019000087A1/en unknown
- 2017-10-02 EP EP17781060.3A patent/EP3519413A1/en active Pending
- 2017-10-02 CA CA3037998A patent/CA3037998A1/en active Pending
- 2017-10-02 KR KR1020197012099A patent/KR102531344B1/ko active IP Right Grant
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2019
- 2019-03-31 IL IL265718A patent/IL265718B/en unknown
- 2019-04-02 MX MX2023005574A patent/MX2023005574A/es unknown
- 2019-04-03 PH PH12019500731A patent/PH12019500731A1/en unknown
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2021
- 2021-07-16 US US17/378,417 patent/US11993614B2/en active Active
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2022
- 2022-03-04 JP JP2022033419A patent/JP2022084699A/ja active Pending
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2023
- 2023-10-17 US US18/488,626 patent/US20240124493A1/en active Pending
Also Published As
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AU2017338269B2 (en) | 2021-03-25 |
IL265718A (en) | 2019-05-30 |
US20210371433A1 (en) | 2021-12-02 |
CA3037998A1 (en) | 2018-04-12 |
TN2019000087A1 (en) | 2020-07-15 |
JP2019534255A (ja) | 2019-11-28 |
US20190263833A1 (en) | 2019-08-29 |
PH12019500731A1 (en) | 2019-06-24 |
AU2017338269A1 (en) | 2019-04-04 |
CN115626935A (zh) | 2023-01-20 |
MA46341A (fr) | 2019-08-07 |
EP3519413A1 (en) | 2019-08-07 |
US11098062B2 (en) | 2021-08-24 |
JP7101171B2 (ja) | 2022-07-14 |
US20240124493A1 (en) | 2024-04-18 |
PE20190706A1 (es) | 2019-05-17 |
UA124074C2 (uk) | 2021-07-14 |
JP2022084699A (ja) | 2022-06-07 |
US11993614B2 (en) | 2024-05-28 |
BR112019006414A2 (pt) | 2019-06-25 |
CN109803971A (zh) | 2019-05-24 |
KR20190056425A (ko) | 2019-05-24 |
IL265718B (en) | 2021-08-31 |
KR102531344B1 (ko) | 2023-05-10 |
CN109803971B (zh) | 2022-10-28 |
MX2023005574A (es) | 2023-05-29 |
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