PE20030849A1 - Agonistas del receptor 2 del factor liberador de la corticotropina - Google Patents

Agonistas del receptor 2 del factor liberador de la corticotropina

Info

Publication number
PE20030849A1
PE20030849A1 PE2003000041A PE2003000041A PE20030849A1 PE 20030849 A1 PE20030849 A1 PE 20030849A1 PE 2003000041 A PE2003000041 A PE 2003000041A PE 2003000041 A PE2003000041 A PE 2003000041A PE 20030849 A1 PE20030849 A1 PE 20030849A1
Authority
PE
Peru
Prior art keywords
agonists
factor receptor
releasing factor
corticotropin releasing
peptide
Prior art date
Application number
PE2003000041A
Other languages
English (en)
Inventor
Robert Joseph Isfort
Wieslaw Adam Mazur
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20030849A1 publication Critical patent/PE20030849A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REFIERE A PEPTIDOS AISLADOS AGONISTAS DEL RECEPTOR DEL FACTOR LIBERADOR DE CORTICOTROPINA (CRF2R) Y ACIDOS NUCLEICOS QUE CODIFICAN LOS MISMOS; UN PEPTIDO NO NATIVO DE SECUENCIA -X2X3PSLSIDX10PX12X13X14LLRTLLELEKTQSQRERAEQNAX36IFAX40V, DONDE: X2 ES D; NADA; X3 ES NADA; N; X10 ES L, V; X12 ES L, F; X13 ES L, F, Y; X14 ES I, L, M; X36 ES R, H, Q; X40 ES H, R. LOS PEPTIDOS SON DE PREFERENCIA DE 41 AMINOACIDOS; TAMBIEN SE REFIERE A UN ANTICUERPO AISLADO ESPECIFICO DEL PEPTIDO; EL PEPTIDO PUEDE SER UTIL PARA EL TRATAMIENTO DE ATROFIA DEL MUSCULO ESQUELETICO O UNA FORMA DE DISTROFIA MUSCULAR
PE2003000041A 2002-01-16 2003-01-14 Agonistas del receptor 2 del factor liberador de la corticotropina PE20030849A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34911702P 2002-01-16 2002-01-16
US37633702P 2002-04-29 2002-04-29
US38889502P 2002-06-14 2002-06-14
US41198802P 2002-09-19 2002-09-19

Publications (1)

Publication Number Publication Date
PE20030849A1 true PE20030849A1 (es) 2003-12-01

Family

ID=27617822

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2003000040A PE20030974A1 (es) 2002-01-16 2003-01-14 Agonistas del receptor 2 del factor liberador de la corticotropina
PE2003000041A PE20030849A1 (es) 2002-01-16 2003-01-14 Agonistas del receptor 2 del factor liberador de la corticotropina
PE2003000039A PE20030747A1 (es) 2002-01-16 2003-01-14 Agonistas del receptor 2 del factor liberador de la corticotropina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2003000040A PE20030974A1 (es) 2002-01-16 2003-01-14 Agonistas del receptor 2 del factor liberador de la corticotropina

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2003000039A PE20030747A1 (es) 2002-01-16 2003-01-14 Agonistas del receptor 2 del factor liberador de la corticotropina

Country Status (30)

Country Link
US (7) US7192924B2 (es)
EP (4) EP1724283B1 (es)
JP (3) JP4508649B2 (es)
KR (3) KR100735586B1 (es)
CN (3) CN1617887A (es)
AR (3) AR038144A1 (es)
AT (4) ATE398632T1 (es)
AU (2) AU2003237419B2 (es)
BR (3) BR0306826A (es)
CA (3) CA2470656C (es)
CY (1) CY1106133T1 (es)
DE (4) DE60321730D1 (es)
DK (2) DK1465921T3 (es)
ES (4) ES2309909T3 (es)
HK (1) HK1078095A1 (es)
IL (5) IL162530A0 (es)
MA (3) MA27590A1 (es)
MX (3) MXPA04006883A (es)
MY (1) MY140306A (es)
NO (3) NO20043366L (es)
NZ (3) NZ533599A (es)
PE (3) PE20030974A1 (es)
PL (3) PL371364A1 (es)
PT (2) PT1465923E (es)
RU (1) RU2294333C2 (es)
SA (3) SA03230564B1 (es)
SI (1) SI1465921T1 (es)
TW (3) TW200302278A (es)
WO (3) WO2003062269A2 (es)
ZA (1) ZA200404995B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001289916A1 (en) * 2000-09-22 2002-04-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US7192924B2 (en) * 2002-01-16 2007-03-20 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists
WO2005103690A2 (en) * 2004-04-24 2005-11-03 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2)
AU2006235045A1 (en) * 2005-03-30 2006-10-19 J. Craig Venter Institute, Inc. Haemophilus influenzae type b
WO2007090087A2 (en) * 2006-01-27 2007-08-09 Research Development Foundation Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases
KR20100061478A (ko) * 2007-09-11 2010-06-07 몬도바이오테크 래보래토리즈 아게 치료제로서의 세크레틴 및 임의의 유로딜라틴의 용도
WO2009033773A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
WO2009046874A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Therapeutic combination of trh-potentiating peptide and stresscopin
EA201170647A1 (ru) * 2008-11-04 2011-12-30 Янссен Фармацевтика Нв Пептиды-агонисты crhr2 и их использование
EP2206726A1 (en) * 2009-01-08 2010-07-14 Universite Joseph Fourier Non-invasive tools for detecting vulnerable atherosclerotic plaques
MX2012005262A (es) * 2009-11-04 2012-09-28 Janssen Pharmaceutica Nv Metodo para tratar la insuficiencia cardiaca con petidos tipo estrescopina.
WO2013063046A1 (en) 2011-10-24 2013-05-02 Research Development Foundation Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
CN104220098B (zh) 2012-02-14 2018-04-10 加利福尼亚大学董事会 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
JOP20170153A1 (ar) 2016-07-15 2019-01-30 Lilly Co Eli نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
AU2017345785A1 (en) * 2016-10-20 2019-05-16 Cortene Inc. Methods of treating diseases resulting from a maladapted stress response
CN110755434B (zh) * 2018-07-27 2022-03-15 中国医学科学院药物研究所 化合物palosuran防治骨骼肌萎缩等疾病的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235036A (en) 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs
EP0860501A3 (en) 1994-06-14 1999-05-19 Neurocrine Biosciences, Inc. Corticotropin-releasing factor2 receptors
US5786203A (en) 1994-06-14 1998-07-28 Neurocrine Biosciences, Inc. Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
US5663292A (en) 1994-12-12 1997-09-02 The Salk Institute For Biological Studies Cyclic CRF analogs
US5824771A (en) 1994-12-12 1998-10-20 The Salk Institute For Biological Studies Cyclic CRF agonists
US5660824A (en) 1995-05-24 1997-08-26 Grabstein; Kenneth H. Muscle trophic factor
CA2223792A1 (en) 1995-06-13 1997-01-03 The Salk Institute For Biological Studies Urocortin peptides
US5869450A (en) 1996-03-06 1999-02-09 The Regents Of The University Of California Anti-inflammatory compositions and method with corticotropin-releasing factor analogs
AU2001284683B2 (en) 2000-08-04 2006-04-27 Research Development Foundation Urocortin proteins and uses thereof
US20020082409A1 (en) 2000-10-26 2002-06-27 Hsu Sheau Yu Stresscopins and their uses
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US7192924B2 (en) * 2002-01-16 2007-03-20 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists

Also Published As

Publication number Publication date
EP1465921B1 (en) 2006-07-26
MXPA04006884A (es) 2004-12-06
MXPA04006883A (es) 2004-12-06
HK1078095A1 (en) 2006-03-03
US7897731B2 (en) 2011-03-01
PL373529A1 (en) 2005-09-05
TW200302278A (en) 2003-08-01
EP1465922B1 (en) 2008-01-09
DE60307044T2 (de) 2007-02-15
ES2269976T3 (es) 2007-04-01
EP1724283B1 (en) 2008-06-18
US6936585B2 (en) 2005-08-30
AR038143A1 (es) 2004-12-29
JP4489434B2 (ja) 2010-06-23
TW200302276A (en) 2003-08-01
ES2299701T3 (es) 2008-06-01
CA2470731A1 (en) 2003-07-31
NO20043396L (no) 2004-10-06
SA03230565A (ar) 2005-12-03
EP1465921A2 (en) 2004-10-13
CA2470731C (en) 2011-06-21
US7192923B2 (en) 2007-03-20
PT1465921E (pt) 2006-12-29
ES2287484T3 (es) 2007-12-16
NZ533598A (en) 2007-03-30
IL162431A0 (en) 2005-11-20
PE20030747A1 (es) 2003-10-23
BR0306838A (pt) 2005-04-05
US7608701B2 (en) 2009-10-27
RU2004124847A (ru) 2005-04-20
KR100758858B1 (ko) 2007-09-14
EP1465923B1 (en) 2007-05-16
US20030148957A1 (en) 2003-08-07
PL373139A1 (en) 2005-08-22
KR20040082390A (ko) 2004-09-24
IL162530A0 (en) 2005-11-20
EP1465922A2 (en) 2004-10-13
WO2003062268A3 (en) 2003-11-27
US7462597B2 (en) 2008-12-09
DE60318547D1 (de) 2008-02-21
TW200302277A (en) 2003-08-01
DE60313845D1 (de) 2007-06-28
TWI300442B (en) 2008-09-01
NZ533600A (en) 2007-02-23
CN1617886A (zh) 2005-05-18
MXPA04006885A (es) 2004-12-06
ATE334147T1 (de) 2006-08-15
CA2470656C (en) 2011-06-28
CN100391972C (zh) 2008-06-04
AU2003205197B2 (en) 2006-03-02
ATE362488T1 (de) 2007-06-15
US20090124793A1 (en) 2009-05-14
US20080004435A1 (en) 2008-01-03
IL196384A0 (en) 2011-07-31
EP1724283A2 (en) 2006-11-22
US20030148958A1 (en) 2003-08-07
AR038144A1 (es) 2004-12-29
IL197774A0 (en) 2009-12-24
DE60307044D1 (de) 2006-09-07
SA03230564A (ar) 2005-12-03
MA27590A1 (fr) 2005-11-01
EP1465923A1 (en) 2004-10-13
JP4508649B2 (ja) 2010-07-21
CN1617887A (zh) 2005-05-18
SA03230564B1 (ar) 2006-10-31
JP4508648B2 (ja) 2010-07-21
PT1465923E (pt) 2007-08-06
AR038142A1 (es) 2004-12-29
NZ533599A (en) 2007-03-30
DE60318547T2 (de) 2008-12-24
BR0306826A (pt) 2005-09-06
WO2003062268A2 (en) 2003-07-31
CA2470656A1 (en) 2003-07-31
MA27591A1 (fr) 2005-11-01
MY140306A (en) 2009-12-31
CN1617885A (zh) 2005-05-18
ES2309909T3 (es) 2008-12-16
CN100475844C (zh) 2009-04-08
US7632933B2 (en) 2009-12-15
MA27592A1 (fr) 2005-11-01
US20100197579A1 (en) 2010-08-05
PL371364A1 (en) 2005-06-13
KR100735586B1 (ko) 2007-07-04
DE60313845T2 (de) 2008-01-31
SI1465921T1 (sl) 2006-10-31
CA2470743C (en) 2011-12-13
ATE398632T1 (de) 2008-07-15
BR0306878A (pt) 2004-10-26
DK1465921T3 (da) 2006-11-27
AU2003237419B2 (en) 2006-04-13
JP2005522191A (ja) 2005-07-28
WO2003062269A2 (en) 2003-07-31
CY1106133T1 (el) 2011-06-08
JP2005525101A (ja) 2005-08-25
WO2003062277A1 (en) 2003-07-31
KR20040082392A (ko) 2004-09-24
SA03230565B1 (ar) 2006-10-31
KR20040082389A (ko) 2004-09-24
PE20030974A1 (es) 2003-12-26
ZA200404995B (en) 2005-06-29
US20060025339A1 (en) 2006-02-02
ATE383372T1 (de) 2008-01-15
WO2003062269A3 (en) 2003-11-06
US7192924B2 (en) 2007-03-20
US20030148956A1 (en) 2003-08-07
DK1465923T3 (da) 2007-07-02
EP1724283A3 (en) 2007-04-11
NO20043366L (no) 2004-10-06
NO20043371L (no) 2004-10-06
RU2294333C2 (ru) 2007-02-27
KR100758857B1 (ko) 2007-09-14
CA2470743A1 (en) 2003-07-31
DE60321730D1 (de) 2008-07-31
JP2005521387A (ja) 2005-07-21
IL162529A0 (en) 2005-11-20

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