ATE316101T1 - Thrombinspaltbare faktor-x-analoga - Google Patents

Thrombinspaltbare faktor-x-analoga

Info

Publication number
ATE316101T1
ATE316101T1 AT03762681T AT03762681T ATE316101T1 AT E316101 T1 ATE316101 T1 AT E316101T1 AT 03762681 T AT03762681 T AT 03762681T AT 03762681 T AT03762681 T AT 03762681T AT E316101 T1 ATE316101 T1 AT E316101T1
Authority
AT
Austria
Prior art keywords
analogues
thrombin
factor
splitting factor
arg
Prior art date
Application number
AT03762681T
Other languages
English (en)
Inventor
Virginie Louvain
Elsa Bianchini
Pierre-Emmanuel Marque
Claire Calmel-Tareau
Martine Aiach
Bonniec Bernard Le
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of ATE316101T1 publication Critical patent/ATE316101T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT03762681T 2002-07-03 2003-06-30 Thrombinspaltbare faktor-x-analoga ATE316101T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0208299A FR2841904B1 (fr) 2002-07-03 2002-07-03 Analogues de facteurs x clivables par la thrombine

Publications (1)

Publication Number Publication Date
ATE316101T1 true ATE316101T1 (de) 2006-02-15

Family

ID=29725108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03762681T ATE316101T1 (de) 2002-07-03 2003-06-30 Thrombinspaltbare faktor-x-analoga

Country Status (10)

Country Link
US (1) US8168753B2 (de)
EP (1) EP1539816B1 (de)
JP (1) JP4533137B2 (de)
AT (1) ATE316101T1 (de)
AU (1) AU2003250095B2 (de)
CA (1) CA2491040C (de)
DE (1) DE60303312T2 (de)
ES (1) ES2257693T3 (de)
FR (1) FR2841904B1 (de)
WO (1) WO2004005347A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2831170B1 (fr) 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
EP1728798A1 (de) * 2005-06-01 2006-12-06 ZLB Behring GmbH Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1816201A1 (de) 2006-02-06 2007-08-08 CSL Behring GmbH Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät
EP1820508A1 (de) 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
WO2008077616A1 (en) 2006-12-22 2008-07-03 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
CN102325880B (zh) 2008-12-19 2014-10-01 国家健康与医学研究院 丝氨酸蛋白酶衍生物及其在凝血功能障碍的预防或治疗中的用途
US9371522B2 (en) 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
US10202595B2 (en) 2012-06-08 2019-02-12 Bioverativ Therapeutics Inc. Chimeric clotting factors
CN104519897A (zh) 2012-06-08 2015-04-15 比奥根艾迪克Ma公司 促凝血化合物
JP6363600B2 (ja) 2012-07-25 2018-07-25 カタリスト・バイオサイエンシーズ・インコーポレイテッドＣａｔａｌｙｓｔ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 修飾第ｘ因子ポリペプチドおよびその使用
KR20150103205A (ko) 2013-01-31 2015-09-09 화이자 인코포레이티드 인자 Xa 억제를 길항하기 위한 조성물 및 방법
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
JP2016510984A (ja) * 2013-03-12 2016-04-14 ノヴォ ノルディスク アー／エス トロンビン感受性凝固第ｘ因子分子
CN105579468A (zh) 2013-09-24 2016-05-11 辉瑞大药厂 包含重组人凝血因子Xa蛋白的异质性群体的组合物
WO2016028872A2 (en) 2014-08-19 2016-02-25 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor ix function

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS634615A (ja) * 1986-06-25 1988-01-09 Hitachi Tokyo Electron Co Ltd 半導体装置製造装置
GB9222758D0 (en) * 1992-10-29 1992-12-09 British Bio Technology Proteins and nucleic acids
US5746875A (en) * 1994-09-16 1998-05-05 Applied Materials, Inc. Gas injection slit nozzle for a plasma process reactor
US6043218A (en) * 1996-10-22 2000-03-28 Medical University Of South Carolina Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides
JP2001504753A (ja) * 1996-11-04 2001-04-10 マテリアルズ モディフィケーション，インコーポレイティド 超微粉のマイクロ波プラズマ化学合成
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
CH697092A5 (de) * 1998-12-24 2008-04-30 Sulzer Metco Ag Anordnung für eine Plasmaspritzanlage.

Also Published As

Publication number Publication date
CA2491040A1 (en) 2004-01-15
WO2004005347A1 (en) 2004-01-15
EP1539816B1 (de) 2006-01-18
FR2841904A1 (fr) 2004-01-09
DE60303312D1 (de) 2006-04-06
AU2003250095A1 (en) 2004-01-23
ES2257693T3 (es) 2006-08-01
US8168753B2 (en) 2012-05-01
CA2491040C (en) 2012-05-01
AU2003250095B2 (en) 2009-04-09
EP1539816A1 (de) 2005-06-15
JP4533137B2 (ja) 2010-09-01
FR2841904B1 (fr) 2004-08-20
JP2006507806A (ja) 2006-03-09
US20060148038A1 (en) 2006-07-06
DE60303312T2 (de) 2006-09-21

Similar Documents

Publication Publication Date Title
ATE316101T1 (de) Thrombinspaltbare faktor-x-analoga
GEP20063741B (en) Nonaryl-Heterocyclic NMDA/NR2B Antagonists
DE602004031301D1 (de) Nichtsymmetrisches geliermittel
ATE446313T1 (de) Muteine von tränen-lipocalin
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
DE60110342D1 (de) Alpha-Interferon enthaltende Hautpflegemittel
HUP0100652A1 (hu) X-Faktor analógok módosított proteáz hasítási hellyel
SE0301653D0 (sv) Novel compounds
RS51764B (en) TRANSDERMAL PHARMACEUTICAL COMPOSITION
RS51694B (en) NEW PERINDOPRIL AND PHARMACEUTICAL COMPOSITIONS CONTAINING THERE
DE60041761D1 (de) Tribonektine
ES2190653T3 (es) Productos de reaccion del acido hialuronico y de aminoacidos naturales y su utilizacion en composiciones cosmeticas y farmaceuticas.
HK1075406A1 (en) Biologically stable liquid composition of fvIII, of vwf or of fviii/vwf complex of human origin
CY1113116T1 (el) Υποκατεστημενες 4-αμινοκυκλοεξανολες
DE50204688D1 (de) N-alkylaziridinoprepolymere als dentalmasse
IL173929A (en) Kahlalid F analogs and their pharmacy preparations
NO964238L (no) Halofantrin-fri-base for behandling av malaria og blandinger
ATE302210T1 (de) Histogranin peptide und deren analgetische verwendung
DE60309480D1 (de) Vitamin d-analoge
ITVA20020023A1 (it) Prodotti per l'edilizia a base di idrossialchilguaro purificato
DE50312414D1 (de) Kompositmaterialien aus calciumverbindungen und glucuronsäurehaltigen polysacchariden
BR9802803A (pt) ação e composições farmacêuticas contendo os mesmos.
DE60318749D1 (de) Paralytisches peptide von der spitzmaus sowie dessen nutzung in der therapie von neuromuskulären krankheiten
HUP0300997A2 (hu) A MIA-fehérje alkalmazása immunterápiában
TR200103240T2 (tr) Endoparazit öldürücü bileşimler.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties