DE60313845D1 - Agonisten des corticotropin-freisetzenden faktor rezeptors 2 - Google Patents

Agonisten des corticotropin-freisetzenden faktor rezeptors 2

Info

Publication number
DE60313845D1
DE60313845D1 DE60313845T DE60313845T DE60313845D1 DE 60313845 D1 DE60313845 D1 DE 60313845D1 DE 60313845 T DE60313845 T DE 60313845T DE 60313845 T DE60313845 T DE 60313845T DE 60313845 D1 DE60313845 D1 DE 60313845D1
Authority
DE
Germany
Prior art keywords
agonists
factor receptor
releasing factor
corticotropin releasing
corticotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60313845T
Other languages
English (en)
Other versions
DE60313845T2 (de
Inventor
Robert Joseph Isfort
Wieslaw Adam Mazur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Co LLC
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of DE60313845D1 publication Critical patent/DE60313845D1/de
Application granted granted Critical
Publication of DE60313845T2 publication Critical patent/DE60313845T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60313845T 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2 Expired - Lifetime DE60313845T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US34911702P 2002-01-16 2002-01-16
US349117P 2002-01-16
US37633702P 2002-04-29 2002-04-29
US376337P 2002-04-29
US38889502P 2002-06-14 2002-06-14
US388895P 2002-06-14
US41198802P 2002-09-19 2002-09-19
US411988P 2002-09-19
PCT/US2003/001454 WO2003062277A1 (en) 2002-01-16 2003-01-16 Corticotropin releasing factor receptor 2 agonists

Publications (2)

Publication Number Publication Date
DE60313845D1 true DE60313845D1 (de) 2007-06-28
DE60313845T2 DE60313845T2 (de) 2008-01-31

Family

ID=27617822

Family Applications (4)

Application Number Title Priority Date Filing Date
DE60321730T Expired - Lifetime DE60321730D1 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden Faktor Rezeptors 2
DE60318547T Expired - Lifetime DE60318547T2 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2
DE60313845T Expired - Lifetime DE60313845T2 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2
DE60307044T Expired - Lifetime DE60307044T2 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE60321730T Expired - Lifetime DE60321730D1 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden Faktor Rezeptors 2
DE60318547T Expired - Lifetime DE60318547T2 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60307044T Expired - Lifetime DE60307044T2 (de) 2002-01-16 2003-01-16 Agonisten des corticotropin-freisetzenden faktor rezeptors 2

Country Status (30)

Country Link
US (7) US6936585B2 (de)
EP (4) EP1465921B1 (de)
JP (3) JP4508649B2 (de)
KR (3) KR100758857B1 (de)
CN (3) CN100391972C (de)
AR (3) AR038144A1 (de)
AT (4) ATE334147T1 (de)
AU (2) AU2003205197B2 (de)
BR (3) BR0306878A (de)
CA (3) CA2470743C (de)
CY (1) CY1106133T1 (de)
DE (4) DE60321730D1 (de)
DK (2) DK1465921T3 (de)
ES (4) ES2299701T3 (de)
HK (1) HK1078095A1 (de)
IL (5) IL162431A0 (de)
MA (3) MA27591A1 (de)
MX (3) MXPA04006885A (de)
MY (1) MY140306A (de)
NO (3) NO20043366L (de)
NZ (3) NZ533599A (de)
PE (3) PE20030974A1 (de)
PL (3) PL373529A1 (de)
PT (2) PT1465921E (de)
RU (1) RU2294333C2 (de)
SA (3) SA03230565B1 (de)
SI (1) SI1465921T1 (de)
TW (3) TW200302278A (de)
WO (3) WO2003062269A2 (de)
ZA (1) ZA200404995B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2427490A1 (en) * 2000-09-22 2002-03-28 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US6936585B2 (en) * 2002-01-16 2005-08-30 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists
WO2005103690A2 (en) * 2004-04-24 2005-11-03 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2)
BRPI0609460A2 (pt) * 2005-03-30 2010-04-13 Novartis Vaccines & Diagnostics Inc haemophilus influenzae tipo b
WO2007090087A2 (en) * 2006-01-27 2007-08-09 Research Development Foundation Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases
WO2009046874A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Therapeutic combination of trh-potentiating peptide and stresscopin
WO2009033773A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
AU2008297874A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of secretin and optionally urodilatin as therapeutic agents
US10040838B2 (en) * 2008-11-04 2018-08-07 Janssen Pharmaceutica Nv CRHR2 peptide agonists and uses thereof
EP2206726A1 (de) * 2009-01-08 2010-07-14 Universite Joseph Fourier Nichtinvasive Instrumente zum Nachweisen anfälliger atherosklerotischer Plaques
MX2012005262A (es) * 2009-11-04 2012-09-28 Janssen Pharmaceutica Nv Metodo para tratar la insuficiencia cardiaca con petidos tipo estrescopina.
WO2013063046A1 (en) 2011-10-24 2013-05-02 Research Development Foundation Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
WO2013123094A2 (en) 2012-02-14 2013-08-22 The Regents Of The University Of California Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
JOP20170153A1 (ar) * 2016-07-15 2019-01-30 Lilly Co Eli نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
MX2019004401A (es) * 2016-10-20 2019-09-26 Cortene Inc Metodos de tratamiento y enfermedades resultantes de una respuesta de tension mal adaptada.
CN110755434B (zh) * 2018-07-27 2022-03-15 中国医学科学院药物研究所 化合物palosuran防治骨骼肌萎缩等疾病的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235036A (en) 1991-05-31 1993-08-10 The Salk Institute For Biological Studies Crf analogs
EP0860501A3 (de) 1994-06-14 1999-05-19 Neurocrine Biosciences, Inc. Corticotropin freisetzende Rezeptoren des Faktor 2
US5786203A (en) 1994-06-14 1998-07-28 Neurocrine Biosciences, Inc. Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
US5824771A (en) 1994-12-12 1998-10-20 The Salk Institute For Biological Studies Cyclic CRF agonists
US5663292A (en) 1994-12-12 1997-09-02 The Salk Institute For Biological Studies Cyclic CRF analogs
US5660824A (en) 1995-05-24 1997-08-26 Grabstein; Kenneth H. Muscle trophic factor
CA2223792A1 (en) 1995-06-13 1997-01-03 The Salk Institute For Biological Studies Urocortin peptides
US5869450A (en) 1996-03-06 1999-02-09 The Regents Of The University Of California Anti-inflammatory compositions and method with corticotropin-releasing factor analogs
AU2001284683B2 (en) 2000-08-04 2006-04-27 Research Development Foundation Urocortin proteins and uses thereof
US20020082409A1 (en) 2000-10-26 2002-06-27 Hsu Sheau Yu Stresscopins and their uses
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6936585B2 (en) * 2002-01-16 2005-08-30 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists

Also Published As

Publication number Publication date
PE20030849A1 (es) 2003-12-01
JP4489434B2 (ja) 2010-06-23
KR100758857B1 (ko) 2007-09-14
MA27591A1 (fr) 2005-11-01
NZ533599A (en) 2007-03-30
JP2005525101A (ja) 2005-08-25
NZ533600A (en) 2007-02-23
PE20030974A1 (es) 2003-12-26
CN100391972C (zh) 2008-06-04
MY140306A (en) 2009-12-31
DK1465923T3 (da) 2007-07-02
US20030148956A1 (en) 2003-08-07
AU2003205197B2 (en) 2006-03-02
ATE398632T1 (de) 2008-07-15
CN1617886A (zh) 2005-05-18
US7192924B2 (en) 2007-03-20
BR0306838A (pt) 2005-04-05
CN1617887A (zh) 2005-05-18
DK1465921T3 (da) 2006-11-27
KR100735586B1 (ko) 2007-07-04
NO20043371L (no) 2004-10-06
ATE383372T1 (de) 2008-01-15
PT1465923E (pt) 2007-08-06
TWI300442B (en) 2008-09-01
KR20040082389A (ko) 2004-09-24
AU2003237419B2 (en) 2006-04-13
SA03230565B1 (ar) 2006-10-31
SA03230564A (ar) 2005-12-03
DE60321730D1 (de) 2008-07-31
US7192923B2 (en) 2007-03-20
US7462597B2 (en) 2008-12-09
US20030148957A1 (en) 2003-08-07
CN100475844C (zh) 2009-04-08
US7632933B2 (en) 2009-12-15
CA2470656A1 (en) 2003-07-31
ATE334147T1 (de) 2006-08-15
NO20043396L (no) 2004-10-06
US6936585B2 (en) 2005-08-30
EP1465921B1 (de) 2006-07-26
MA27590A1 (fr) 2005-11-01
ES2269976T3 (es) 2007-04-01
PL373139A1 (en) 2005-08-22
EP1724283A2 (de) 2006-11-22
PL371364A1 (en) 2005-06-13
MXPA04006884A (es) 2004-12-06
MXPA04006885A (es) 2004-12-06
WO2003062277A1 (en) 2003-07-31
JP2005522191A (ja) 2005-07-28
MXPA04006883A (es) 2004-12-06
RU2294333C2 (ru) 2007-02-27
WO2003062269A3 (en) 2003-11-06
ATE362488T1 (de) 2007-06-15
ES2287484T3 (es) 2007-12-16
DE60313845T2 (de) 2008-01-31
EP1724283B1 (de) 2008-06-18
TW200302278A (en) 2003-08-01
US7608701B2 (en) 2009-10-27
NZ533598A (en) 2007-03-30
ES2309909T3 (es) 2008-12-16
TW200302277A (en) 2003-08-01
US20060025339A1 (en) 2006-02-02
TW200302276A (en) 2003-08-01
EP1465923A1 (de) 2004-10-13
WO2003062268A3 (en) 2003-11-27
EP1465922A2 (de) 2004-10-13
IL196384A0 (en) 2011-07-31
WO2003062268A2 (en) 2003-07-31
IL162431A0 (en) 2005-11-20
SI1465921T1 (sl) 2006-10-31
SA03230564B1 (ar) 2006-10-31
BR0306826A (pt) 2005-09-06
CA2470731C (en) 2011-06-21
JP2005521387A (ja) 2005-07-21
EP1465921A2 (de) 2004-10-13
RU2004124847A (ru) 2005-04-20
AR038143A1 (es) 2004-12-29
DE60318547T2 (de) 2008-12-24
AR038144A1 (es) 2004-12-29
IL162530A0 (en) 2005-11-20
US20030148958A1 (en) 2003-08-07
KR20040082390A (ko) 2004-09-24
KR20040082392A (ko) 2004-09-24
US20090124793A1 (en) 2009-05-14
SA03230565A (ar) 2005-12-03
US20080004435A1 (en) 2008-01-03
ZA200404995B (en) 2005-06-29
CA2470743C (en) 2011-12-13
HK1078095A1 (en) 2006-03-03
PT1465921E (pt) 2006-12-29
CA2470656C (en) 2011-06-28
US20100197579A1 (en) 2010-08-05
CA2470731A1 (en) 2003-07-31
PL373529A1 (en) 2005-09-05
NO20043366L (no) 2004-10-06
DE60307044T2 (de) 2007-02-15
CN1617885A (zh) 2005-05-18
DE60307044D1 (de) 2006-09-07
WO2003062269A2 (en) 2003-07-31
PE20030747A1 (es) 2003-10-23
ES2299701T3 (es) 2008-06-01
BR0306878A (pt) 2004-10-26
IL197774A0 (en) 2009-12-24
EP1465923B1 (de) 2007-05-16
JP4508649B2 (ja) 2010-07-21
AR038142A1 (es) 2004-12-29
EP1724283A3 (de) 2007-04-11
KR100758858B1 (ko) 2007-09-14
JP4508648B2 (ja) 2010-07-21
US7897731B2 (en) 2011-03-01
CA2470743A1 (en) 2003-07-31
DE60318547D1 (de) 2008-02-21
IL162529A0 (en) 2005-11-20
CY1106133T1 (el) 2011-06-08
EP1465922B1 (de) 2008-01-09
MA27592A1 (fr) 2005-11-01

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Legal Events

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Owner name: WARNER CHILCOTT COMPANY, LLC, FAJARDO, P.R., US