PE20030137A1 - Derivados antimicrobianos de quinolona - Google Patents

Derivados antimicrobianos de quinolona

Info

Publication number
PE20030137A1
PE20030137A1 PE2001001284A PE2001001284A PE20030137A1 PE 20030137 A1 PE20030137 A1 PE 20030137A1 PE 2001001284 A PE2001001284 A PE 2001001284A PE 2001001284 A PE2001001284 A PE 2001001284A PE 20030137 A1 PE20030137 A1 PE 20030137A1
Authority
PE
Peru
Prior art keywords
alkyl
quinolone
ona
carboxi
alcoxy
Prior art date
Application number
PE2001001284A
Other languages
English (en)
Spanish (es)
Inventor
Mikhail Gordeev
Michael R Barbachyn
Dinesh V Patel
James R Gage
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20030137A1 publication Critical patent/PE20030137A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PE2001001284A 2000-12-21 2001-12-20 Derivados antimicrobianos de quinolona PE20030137A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25790400P 2000-12-21 2000-12-21

Publications (1)

Publication Number Publication Date
PE20030137A1 true PE20030137A1 (es) 2003-03-08

Family

ID=22978270

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001284A PE20030137A1 (es) 2000-12-21 2001-12-20 Derivados antimicrobianos de quinolona

Country Status (9)

Country Link
US (2) US6689769B2 (cg-RX-API-DMAC7.html)
EP (1) EP1349853B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004518677A (cg-RX-API-DMAC7.html)
AT (1) ATE319710T1 (cg-RX-API-DMAC7.html)
CA (1) CA2424402A1 (cg-RX-API-DMAC7.html)
DE (1) DE60117861T2 (cg-RX-API-DMAC7.html)
ES (1) ES2256331T3 (cg-RX-API-DMAC7.html)
PE (1) PE20030137A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002059116A2 (cg-RX-API-DMAC7.html)

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US6875784B2 (en) * 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
ES2312839T3 (es) * 2002-12-04 2009-03-01 Glaxo Group Limited Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos.
JP2006516991A (ja) * 2003-02-07 2006-07-13 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 抗菌剤
WO2004069244A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents
ATE397930T1 (de) * 2003-04-30 2008-07-15 Morphochem Ag Komb Chemie Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
EP1646629B1 (en) 2003-07-02 2010-06-23 Merck Sharp & Dohme Corp. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
DK1709044T4 (da) * 2003-12-18 2014-01-20 Morphochem Ag Komb Chemie Oxazolidinon-quinolon-hybridantibiotika
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1732897A1 (en) * 2004-03-31 2006-12-20 Bayer Pharmaceuticals Corporation Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
US8546423B2 (en) * 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
EP2028936A4 (en) * 2006-02-13 2014-02-26 Univ Boston COMPOSITIONS AND METHODS FOR ANTIBIOTIC REINFORCEMENT AND ACTIVE INFLUENCE
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
ES2380388T3 (es) * 2006-11-10 2012-05-11 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona
CN102014903B (zh) * 2008-05-09 2013-07-10 埃科特莱茵药品有限公司 用于治疗细菌性肠疾病的5-羟基甲基-*唑烷-2-酮衍生物
KR100980681B1 (ko) * 2008-09-16 2010-09-07 한국과학기술연구원 디플루오로페닐 유도체를 갖는 신규한 옥사졸리디논 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 항생제 조성물
JP2012505223A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 薬物動態の改善のためのエアゾールフルオロキノロン配合物
US8629139B2 (en) * 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
CN102724983A (zh) 2009-09-04 2012-10-10 Mpex医药有限公司 雾化左氧氟沙星治疗囊性纤维化的用途
CN102040591B (zh) * 2009-10-15 2013-12-11 山东轩竹医药科技有限公司 7-苯基喹诺酮类化合物
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
WO2014191109A1 (en) 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
CN112089714A (zh) 2013-05-28 2020-12-18 莫弗凯姆有限公司 用于胃肠外治疗或预防细菌性疾病的噁唑烷酮-喹诺酮杂合物抗菌剂
WO2017017631A2 (en) 2015-07-28 2017-02-02 Vyome Biosciences Pvt. Ltd. Antibacterial therapeutics and prophylactics
WO2017156519A1 (en) 2016-03-11 2017-09-14 The Board Of Trustees Of The University Of Illinois Small-molecules active against gram-negative bacteria
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
WO2018237140A1 (en) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and antcancer activity

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Also Published As

Publication number Publication date
DE60117861T2 (de) 2006-11-02
US6869965B2 (en) 2005-03-22
US20030013737A1 (en) 2003-01-16
WO2002059116A3 (en) 2002-12-05
EP1349853A2 (en) 2003-10-08
ATE319710T1 (de) 2006-03-15
WO2002059116A2 (en) 2002-08-01
EP1349853B1 (en) 2006-03-08
US20040215017A1 (en) 2004-10-28
DE60117861D1 (de) 2006-05-04
US6689769B2 (en) 2004-02-10
CA2424402A1 (en) 2002-08-01
ES2256331T3 (es) 2006-07-16
JP2004518677A (ja) 2004-06-24

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