CA2424402A1 - Antimicrobial quinolone derivatives and use of the same to treat bacterial infections - Google Patents

Antimicrobial quinolone derivatives and use of the same to treat bacterial infections Download PDF

Info

Publication number
CA2424402A1
CA2424402A1 CA002424402A CA2424402A CA2424402A1 CA 2424402 A1 CA2424402 A1 CA 2424402A1 CA 002424402 A CA002424402 A CA 002424402A CA 2424402 A CA2424402 A CA 2424402A CA 2424402 A1 CA2424402 A1 CA 2424402A1
Authority
CA
Canada
Prior art keywords
group
compound
methyl
halo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002424402A
Other languages
English (en)
French (fr)
Inventor
Mikhail F. Gordeev
Dinesh V. Patel
Michael R. Barbachyn
James R. Gage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2424402A1 publication Critical patent/CA2424402A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA002424402A 2000-12-21 2001-11-29 Antimicrobial quinolone derivatives and use of the same to treat bacterial infections Abandoned CA2424402A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25790400P 2000-12-21 2000-12-21
US60/257,904 2000-12-21
PCT/US2001/044731 WO2002059116A2 (en) 2000-12-21 2001-11-29 Antimicrobial quinolone derivatives and use of the same to treat bacterial infections

Publications (1)

Publication Number Publication Date
CA2424402A1 true CA2424402A1 (en) 2002-08-01

Family

ID=22978270

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002424402A Abandoned CA2424402A1 (en) 2000-12-21 2001-11-29 Antimicrobial quinolone derivatives and use of the same to treat bacterial infections

Country Status (9)

Country Link
US (2) US6689769B2 (cg-RX-API-DMAC7.html)
EP (1) EP1349853B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004518677A (cg-RX-API-DMAC7.html)
AT (1) ATE319710T1 (cg-RX-API-DMAC7.html)
CA (1) CA2424402A1 (cg-RX-API-DMAC7.html)
DE (1) DE60117861T2 (cg-RX-API-DMAC7.html)
ES (1) ES2256331T3 (cg-RX-API-DMAC7.html)
PE (1) PE20030137A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002059116A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820823B2 (en) 2001-10-04 2010-10-26 Morphochem Aktiengesellschaft Fur Kominatorische Chemi Dual action antibiotics

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US6875784B2 (en) * 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
ES2312839T3 (es) * 2002-12-04 2009-03-01 Glaxo Group Limited Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos.
JP2006516991A (ja) * 2003-02-07 2006-07-13 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 抗菌剤
WO2004069244A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents
ATE397930T1 (de) * 2003-04-30 2008-07-15 Morphochem Ag Komb Chemie Verwendung von oxazolidinon-chinolin-hybrid- antibiotika zur behandlung von anthrax und anderen infektionen
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
EP1646629B1 (en) 2003-07-02 2010-06-23 Merck Sharp & Dohme Corp. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
DK1709044T4 (da) * 2003-12-18 2014-01-20 Morphochem Ag Komb Chemie Oxazolidinon-quinolon-hybridantibiotika
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1732897A1 (en) * 2004-03-31 2006-12-20 Bayer Pharmaceuticals Corporation Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
US8546423B2 (en) * 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
EP2028936A4 (en) * 2006-02-13 2014-02-26 Univ Boston COMPOSITIONS AND METHODS FOR ANTIBIOTIC REINFORCEMENT AND ACTIVE INFLUENCE
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
ES2380388T3 (es) * 2006-11-10 2012-05-11 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona
CN102014903B (zh) * 2008-05-09 2013-07-10 埃科特莱茵药品有限公司 用于治疗细菌性肠疾病的5-羟基甲基-*唑烷-2-酮衍生物
KR100980681B1 (ko) * 2008-09-16 2010-09-07 한국과학기술연구원 디플루오로페닐 유도체를 갖는 신규한 옥사졸리디논 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 항생제 조성물
JP2012505223A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 薬物動態の改善のためのエアゾールフルオロキノロン配合物
US8629139B2 (en) * 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
CN102724983A (zh) 2009-09-04 2012-10-10 Mpex医药有限公司 雾化左氧氟沙星治疗囊性纤维化的用途
CN102040591B (zh) * 2009-10-15 2013-12-11 山东轩竹医药科技有限公司 7-苯基喹诺酮类化合物
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
WO2014191109A1 (en) 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
CN112089714A (zh) 2013-05-28 2020-12-18 莫弗凯姆有限公司 用于胃肠外治疗或预防细菌性疾病的噁唑烷酮-喹诺酮杂合物抗菌剂
WO2017017631A2 (en) 2015-07-28 2017-02-02 Vyome Biosciences Pvt. Ltd. Antibacterial therapeutics and prophylactics
WO2017156519A1 (en) 2016-03-11 2017-09-14 The Board Of Trustees Of The University Of Illinois Small-molecules active against gram-negative bacteria
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
WO2018237140A1 (en) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and antcancer activity

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137326C (cg-RX-API-DMAC7.html) 1967-08-26
US3669965A (en) 1969-12-29 1972-06-13 Lilly Co Eli 1-lower alkyl or alkylene substituted-6,7-methylenedioxy-4(1h)-oxocinnoline-3-carboxylic acids and methods for making and using same
US4000155A (en) 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
US4283403A (en) 1976-06-14 1981-08-11 Eli Lilly And Company Substituted isoxazolines for control of plant phytopathogens
IL51092A0 (en) * 1976-12-10 1977-02-28 Abic Ltd Naphthyridine derivatives and their preparation
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
DE3142854A1 (de) 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4620007A (en) 1980-09-03 1986-10-28 Bayer Aktiengesellschaft 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
JPS5788182A (en) 1980-11-21 1982-06-01 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazinecarboxylic acid derivative
JPS5872589A (ja) 1981-10-28 1983-04-30 Dai Ichi Seiyaku Co Ltd ピリド〔１，２，３−ｄｅ〕〔１，４〕ベンゾオキサジン誘導体
DE3248507A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3248505A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
DK170473B1 (da) 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
US4921869A (en) 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4977173A (en) 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5254577A (en) 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5130316A (en) 1988-07-29 1992-07-14 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents
JPH0269478A (ja) * 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5164510A (en) 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
ATE123494T1 (de) * 1989-03-30 1995-06-15 Wakunaga Seiyaku Kk Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe.
DE69216251T2 (de) 1991-11-01 1997-05-15 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte aryl- und heteroaryl-phenyloxazolidinone
HUT74099A (en) 1992-12-08 1996-11-28 Upjohn Co Tropone-substituted phenyloxazolidinone antibacterial agents and pharmaceutical compositions containing the same
DE4425609A1 (de) 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
US6124334A (en) * 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
WO1998007708A1 (en) 1996-08-21 1998-02-26 Pharmacia & Upjohn Company Isoxazoline derivatives useful as antimicrobials
DK1054874T3 (da) 1998-02-13 2002-12-30 Upjohn Co Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820823B2 (en) 2001-10-04 2010-10-26 Morphochem Aktiengesellschaft Fur Kominatorische Chemi Dual action antibiotics
US8329908B2 (en) 2001-10-04 2012-12-11 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Dual action antibiotics

Also Published As

Publication number Publication date
DE60117861T2 (de) 2006-11-02
US6869965B2 (en) 2005-03-22
US20030013737A1 (en) 2003-01-16
WO2002059116A3 (en) 2002-12-05
EP1349853A2 (en) 2003-10-08
ATE319710T1 (de) 2006-03-15
PE20030137A1 (es) 2003-03-08
WO2002059116A2 (en) 2002-08-01
EP1349853B1 (en) 2006-03-08
US20040215017A1 (en) 2004-10-28
DE60117861D1 (de) 2006-05-04
US6689769B2 (en) 2004-02-10
ES2256331T3 (es) 2006-07-16
JP2004518677A (ja) 2004-06-24

Similar Documents

Publication Publication Date Title
US6689769B2 (en) Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
RU2278117C2 (ru) Антибактериальные гетеробициклические замещенные фенилоксазолидиноны
KR100463771B1 (ko) 스피로환식또는이환식디아지닐또는카바지닐옥사졸리디논
JP2002502854A (ja) アゾール−含有三環を有する新規なオキサゾリジノン類
SK572004A3 (en) New derivatives of oxazolidinones as antibacterial agents
CA2405532A1 (en) Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
ZA200109384B (en) Bicyclic Oxazolidinones as antibacterial agent.
RU2617408C2 (ru) Новое производное оксазолидинона и включающая его фармацевтическая композиция
US6365612B2 (en) Benzosultam oxazolidinone antibacterial agents
JP2007511597A (ja) 抗菌アミノキナゾリヂンヂオン誘導体
AU2001247540A1 (en) Novel benzosultam oxazolidinone antibacterial agents
WO2007040326A1 (en) A novel oxazolidinone formamide derivative and preparation method therof
KR100856745B1 (ko) 헤테로 고리 및 헤테로아로마틱 고리가 치환 또는 융합된피리딘을 포함하는 옥사졸리디논 유도체 및 그의 제조방법
KR100629327B1 (ko) 신규 트리아졸릴메틸옥사졸리디논 유도체
KR0150742B1 (ko) 신규한 퀴놀린 카르복실산 유도체 및 그의 제조방법
JP2621204B2 (ja) 抗菌化合物
SG185169A1 (en) Biphenyl oxazolidinone antibiotic
WO2010012138A1 (zh) 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法
HK1052339A (en) Novel benzosultam oxazolidinone antibacterial agents
JPH0559067A (ja) ５−ハロゲノチアゼトキノリン−３−カルボン酸誘導体
WO2009040754A2 (en) Polymorphs of s-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1h,5h-benzo[i,j]quinolizine-2-carboxylic acid lysine salt

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued