PE20020853A1 - Composiciones farmaceuticas, formas de dosificacion y metodos para la administracion oral de epotilonas - Google Patents
Composiciones farmaceuticas, formas de dosificacion y metodos para la administracion oral de epotilonasInfo
- Publication number
- PE20020853A1 PE20020853A1 PE2002000061A PE2002000061A PE20020853A1 PE 20020853 A1 PE20020853 A1 PE 20020853A1 PE 2002000061 A PE2002000061 A PE 2002000061A PE 2002000061 A PE2002000061 A PE 2002000061A PE 20020853 A1 PE20020853 A1 PE 20020853A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- epotilones
- heterocycle
- methods
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN METODO PARA AUMENTAR LA BIODISPONIBILIDAD DE EPOTILONOS DE FORMULA I, II, ADMINISTRADOS ORALMENTE; DONDE G ES ALQUILO, ARIL, HETEROCICLO; R8HC=C(R9)-, DR10HC-; (R11)(R12)N-C(O)-, W ES O, NR16; X ES O, S, CHR17, H, R18; Y ES H, H; H, OR22; OR23, OR23; NOR24; NOR25, NHNR28R29, NHNR30, CHR32, ENTRE OTROS; B1 Y B2 SON H, OR33, OCOR34; OCONR35R36, NR37R38; D ES NR42R43, HETEROCICLO; R1, R2, R3, R4, R5 SON H, ALQUILO; R8, R9, R10, R11 SON H, ALQUILO, ARIL, CICLOALQUILO, HETEROCICLO; R17, R18, R22, R23 SON H, ALQUILO; R24, R25, R26, R28, R30, R32, R33, R34, R35, R36, R37, R39, R40, R41, R42, R51, R52, R53, R61 SON H, ALQUILO, ARIL; R12, R16, R27, R29, R31, R38, R43 SON H, ALQUILO, ARIL, CICLOALQUILO, HETEROCICLO, R51, CO; R52OCO, R53SO2, HIDROXI, O-ALQUILO Y UN BUFFER TAL COMO FOSFATO DE SODIO DIBASICO ANHIDRO, DIHIDRATO CITRATO DE SODIO, ACIDO CITRICO ANHIDRO CON UN pH DE 5 A 9 SIENDO EL SOLVENTE RECONSTITUYENTE UNA MEZCLA DE PROPILENGLICOL Y ETANOL. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE DE 0,05mg A 200mg DE EPOTILONO, BUFFER. UN COMPUESTO PREFERIDO [1S-[1R*,3R*(E),7R*,10S*,11R*,16S*]]-7,11-DIHIDROXI-8,8,10,12,16-PENTAETIL-3-[1-METIL-2-(2-METIL-4-TIAZOL)ETENIL-17-OXA-4-AZABICICLO[14.1.0]HEPTADECANO-5,9-DIONA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26422801P | 2001-01-25 | 2001-01-25 | |
US29001901P | 2001-05-11 | 2001-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020853A1 true PE20020853A1 (es) | 2002-09-27 |
Family
ID=26950349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000061A PE20020853A1 (es) | 2001-01-25 | 2002-01-25 | Composiciones farmaceuticas, formas de dosificacion y metodos para la administracion oral de epotilonas |
Country Status (26)
Country | Link |
---|---|
US (2) | US6576651B2 (es) |
EP (1) | EP1361877A1 (es) |
JP (1) | JP2004528287A (es) |
KR (1) | KR20040025888A (es) |
CN (1) | CN1268336C (es) |
AR (1) | AR035078A1 (es) |
BG (1) | BG108027A (es) |
BR (1) | BR0206695A (es) |
CA (1) | CA2434584A1 (es) |
CZ (1) | CZ20032023A3 (es) |
EE (1) | EE200300329A (es) |
HR (1) | HRP20030674A2 (es) |
HU (1) | HUP0303800A3 (es) |
IL (1) | IL156759A0 (es) |
IS (1) | IS6892A (es) |
MX (1) | MXPA03006476A (es) |
NO (1) | NO20033343L (es) |
NZ (1) | NZ526871A (es) |
PE (1) | PE20020853A1 (es) |
PL (1) | PL368636A1 (es) |
RU (1) | RU2291695C2 (es) |
SK (1) | SK9212003A3 (es) |
TW (1) | TWI250017B (es) |
UY (1) | UY27138A1 (es) |
WO (2) | WO2002058699A1 (es) |
YU (1) | YU58103A (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
KR100804873B1 (ko) | 1999-06-10 | 2008-02-20 | 얼라이드시그날 인코퍼레이티드 | 포토리소그래피용 sog 반사방지 코팅 |
US6824879B2 (en) | 1999-06-10 | 2004-11-30 | Honeywell International Inc. | Spin-on-glass anti-reflective coatings for photolithography |
US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
WO2002058699A1 (en) | 2001-01-25 | 2002-08-01 | Bristol-Myers Squibb Company | Pharmaceutical forms of epothilones for oral administration |
PL367260A1 (en) * | 2001-01-25 | 2005-02-21 | Bristol-Myers Squibb Company | Parenteral formulation containing epothilone analogs |
CN1774253A (zh) | 2001-02-20 | 2006-05-17 | 布里斯托尔-迈尔斯斯奎布公司 | 用环氧丙酯酮衍生物治疗顽固性肿瘤 |
SK11082003A3 (sk) * | 2001-03-14 | 2004-08-03 | Bristol-Myers Squibb Company | Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení |
CN1606713B (zh) | 2001-11-15 | 2011-07-06 | 霍尼韦尔国际公司 | 用于照相平版印刷术的旋涂抗反射涂料 |
US7211593B2 (en) * | 2002-03-12 | 2007-05-01 | Bristol-Myers Squibb Co. | C12-cyano epothilone derivatives |
TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
DK1767535T3 (da) | 2002-08-23 | 2010-04-12 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
EP1551425A4 (en) * | 2002-10-09 | 2006-09-20 | Kosan Biosciences Inc | THERAPEUTIC FORMULATIONS |
US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
EA012798B1 (ru) * | 2003-08-26 | 2009-12-30 | Шир Холдингз Аг | Фармацевтический состав, содержащий карбонат лантана (варианты) |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
CA2545806C (en) | 2003-11-14 | 2014-09-16 | Brigham And Women's Hospital, Inc. | Methods of modulating immunity |
US8053159B2 (en) | 2003-11-18 | 2011-11-08 | Honeywell International Inc. | Antireflective coatings for via fill and photolithography applications and methods of preparation thereof |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
US20060069136A1 (en) * | 2004-09-24 | 2006-03-30 | Ulrich Klar | Use of Epothilones in the treatment of bone metastasis |
WO2006055742A1 (en) * | 2004-11-18 | 2006-05-26 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
PL1817013T3 (pl) * | 2004-11-18 | 2009-01-30 | Bristol Myers Squibb Co | Dojelitowa powlekana peletka zawierająca Ixabepilone |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
US8642246B2 (en) | 2007-02-26 | 2014-02-04 | Honeywell International Inc. | Compositions, coatings and films for tri-layer patterning applications and methods of preparation thereof |
PL2276485T3 (pl) | 2008-04-24 | 2014-12-31 | Bristol Myers Squibb Co | Stosowanie epotilonu D w leczeniu chorób związanych z Tau, w tym choroby Alzheimera |
US8557877B2 (en) | 2009-06-10 | 2013-10-15 | Honeywell International Inc. | Anti-reflective coatings for optically transparent substrates |
DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
US8864898B2 (en) | 2011-05-31 | 2014-10-21 | Honeywell International Inc. | Coating formulations for optical elements |
CN102276433B (zh) * | 2011-06-30 | 2016-04-20 | 南昌大学 | 木豆素c及其衍生物及其在制备抗癌药物中的应用 |
US10544329B2 (en) | 2015-04-13 | 2020-01-28 | Honeywell International Inc. | Polysiloxane formulations and coatings for optoelectronic applications |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
ATE249463T1 (de) | 1995-11-17 | 2003-09-15 | Biotechnolog Forschung Gmbh | Epothilonderivate, herstellung und verwendung |
DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
PT932399E (pt) * | 1996-03-12 | 2006-05-31 | Pg Txl Co Lp | Pro-farmacos de paclitaxel hidrossoluveis |
WO1998008849A1 (de) | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
DE19636343C1 (de) * | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
EP1367057B1 (de) | 1996-11-18 | 2008-09-17 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilone E und F |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
JP4579351B2 (ja) * | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
HU228851B1 (en) | 1997-02-25 | 2013-06-28 | Biotechnolog Forschung Gmbh | Process for preparing epothilones with a modified side chain and compounds prepared by this process |
DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
JP4065573B2 (ja) | 1997-04-18 | 2008-03-26 | ベーリンガー・インゲルハイム・インテルナツィオナール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 反応媒体として圧縮二酸化炭素中における二官能性または多官能性基質の選択的オレフィンメタセシス |
DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
ATE224882T1 (de) | 1997-07-16 | 2002-10-15 | Schering Ag | Thiazolderivate, verfahren zur herstellung und verwendung |
DK1005465T3 (da) | 1997-08-09 | 2007-11-05 | Bayer Schering Pharma Ag | Nye epothilon-derivater, fremgangsmåde til fremstilling heraf og deres farmaceutiske anvendelse |
US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
NZ506389A (en) | 1998-02-05 | 2003-07-25 | Novartis Ag | Pharmaceutical compositions containing epothilone which can be optionally lyophilised |
US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
ATE307123T1 (de) | 1998-02-25 | 2005-11-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen |
FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
US6399638B1 (en) | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
WO2000000485A1 (de) | 1998-06-30 | 2000-01-06 | Schering Aktiengesellschaft | Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung |
CN100381566C (zh) | 1998-11-20 | 2008-04-16 | 科森生物科学公司 | 产生环氧噻酮及其衍生物的重组方法和材料 |
BR9916833A (pt) | 1998-12-22 | 2001-09-25 | Novartis Ag | Derivados de epotilona e seu uso como agentes antitumor |
HUP0105478A3 (en) | 1999-02-18 | 2002-08-28 | Schering Ag | 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use |
US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
PE20010116A1 (es) | 1999-04-30 | 2001-02-15 | Schering Ag | Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion |
WO2002058699A1 (en) | 2001-01-25 | 2002-08-01 | Bristol-Myers Squibb Company | Pharmaceutical forms of epothilones for oral administration |
PL207720B1 (pl) | 2001-01-25 | 2011-01-31 | Bristol Myers Squibb Co | Sposób przygotowania preparatu farmaceutycznego i jego zastosowanie, farmaceutyczny produkt oraz sposób wytwarzania kompozycji farmaceutycznej |
SK11082003A3 (sk) | 2001-03-14 | 2004-08-03 | Bristol-Myers Squibb Company | Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení |
-
2002
- 2002-01-22 WO PCT/US2002/001693 patent/WO2002058699A1/en not_active Application Discontinuation
- 2002-01-22 NZ NZ526871A patent/NZ526871A/en unknown
- 2002-01-25 PE PE2002000061A patent/PE20020853A1/es not_active Application Discontinuation
- 2002-01-25 EE EEP200300329A patent/EE200300329A/xx unknown
- 2002-01-25 EP EP02723073A patent/EP1361877A1/en not_active Withdrawn
- 2002-01-25 WO PCT/US2002/002518 patent/WO2002058701A1/en not_active Application Discontinuation
- 2002-01-25 CZ CZ20032023A patent/CZ20032023A3/cs unknown
- 2002-01-25 CA CA002434584A patent/CA2434584A1/en not_active Abandoned
- 2002-01-25 AR ARP020100288A patent/AR035078A1/es unknown
- 2002-01-25 JP JP2002559035A patent/JP2004528287A/ja not_active Withdrawn
- 2002-01-25 IL IL15675902A patent/IL156759A0/xx unknown
- 2002-01-25 SK SK921-2003A patent/SK9212003A3/sk unknown
- 2002-01-25 YU YU58103A patent/YU58103A/sh unknown
- 2002-01-25 KR KR10-2003-7009781A patent/KR20040025888A/ko not_active Application Discontinuation
- 2002-01-25 BR BR0206695-5A patent/BR0206695A/pt not_active IP Right Cessation
- 2002-01-25 RU RU2003126174/15A patent/RU2291695C2/ru not_active IP Right Cessation
- 2002-01-25 UY UY27138A patent/UY27138A1/es not_active Application Discontinuation
- 2002-01-25 TW TW091101287A patent/TWI250017B/zh not_active IP Right Cessation
- 2002-01-25 HU HU0303800A patent/HUP0303800A3/hu unknown
- 2002-01-25 PL PL02368636A patent/PL368636A1/xx not_active Application Discontinuation
- 2002-01-25 MX MXPA03006476A patent/MXPA03006476A/es unknown
- 2002-01-25 CN CNB028069927A patent/CN1268336C/zh not_active Expired - Fee Related
- 2002-01-25 US US10/057,390 patent/US6576651B2/en not_active Ceased
-
2003
- 2003-07-24 NO NO20033343A patent/NO20033343L/no not_active Application Discontinuation
- 2003-07-24 BG BG108027A patent/BG108027A/bg unknown
- 2003-07-24 IS IS6892A patent/IS6892A/is unknown
- 2003-08-25 HR HR20030674A patent/HRP20030674A2/hr not_active Application Discontinuation
-
2005
- 2005-06-09 US US11/149,501 patent/USRE40387E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR20040025888A (ko) | 2004-03-26 |
USRE40387E1 (en) | 2008-06-17 |
NZ526871A (en) | 2006-01-27 |
IL156759A0 (en) | 2004-02-08 |
EP1361877A1 (en) | 2003-11-19 |
NO20033343L (no) | 2003-09-24 |
UY27138A1 (es) | 2002-08-30 |
RU2291695C2 (ru) | 2007-01-20 |
CZ20032023A3 (cs) | 2005-03-16 |
CN1498106A (zh) | 2004-05-19 |
WO2002058699A1 (en) | 2002-08-01 |
RU2003126174A (ru) | 2005-02-27 |
TWI250017B (en) | 2006-03-01 |
BR0206695A (pt) | 2004-04-20 |
YU58103A (sh) | 2006-03-03 |
AR035078A1 (es) | 2004-04-14 |
US20020177615A1 (en) | 2002-11-28 |
NO20033343D0 (no) | 2003-07-24 |
CA2434584A1 (en) | 2002-08-01 |
BG108027A (bg) | 2004-12-30 |
HUP0303800A2 (hu) | 2004-03-29 |
IS6892A (is) | 2003-07-24 |
HUP0303800A3 (en) | 2005-02-28 |
AU2002253880B2 (en) | 2006-11-09 |
MXPA03006476A (es) | 2003-09-22 |
US6576651B2 (en) | 2003-06-10 |
PL368636A1 (en) | 2005-04-04 |
HRP20030674A2 (en) | 2005-06-30 |
JP2004528287A (ja) | 2004-09-16 |
WO2002058701A1 (en) | 2002-08-01 |
EE200300329A (et) | 2003-10-15 |
CN1268336C (zh) | 2006-08-09 |
SK9212003A3 (en) | 2004-11-03 |
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