PE20020386A1 - Derivados de tetrazolil-fenil acetamida como activadores de glucoquinasa - Google Patents

Derivados de tetrazolil-fenil acetamida como activadores de glucoquinasa

Info

Publication number
PE20020386A1
PE20020386A1 PE2001000814A PE2001000814A PE20020386A1 PE 20020386 A1 PE20020386 A1 PE 20020386A1 PE 2001000814 A PE2001000814 A PE 2001000814A PE 2001000814 A PE2001000814 A PE 2001000814A PE 20020386 A1 PE20020386 A1 PE 20020386A1
Authority
PE
Peru
Prior art keywords
glucokinase activators
phenyl
tetrazolil
cyclopentil
tetrazol
Prior art date
Application number
PE2001000814A
Other languages
English (en)
Spanish (es)
Inventor
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20020386A1 publication Critical patent/PE20020386A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PE2001000814A 2000-08-15 2001-08-15 Derivados de tetrazolil-fenil acetamida como activadores de glucoquinasa PE20020386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22549400P 2000-08-15 2000-08-15

Publications (1)

Publication Number Publication Date
PE20020386A1 true PE20020386A1 (es) 2002-05-13

Family

ID=22845106

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000814A PE20020386A1 (es) 2000-08-15 2001-08-15 Derivados de tetrazolil-fenil acetamida como activadores de glucoquinasa

Country Status (20)

Country Link
US (3) US6369232B1 (enrdf_load_stackoverflow)
EP (1) EP1311504B1 (enrdf_load_stackoverflow)
JP (1) JP3961948B2 (enrdf_load_stackoverflow)
KR (1) KR100518061B1 (enrdf_load_stackoverflow)
CN (1) CN1209362C (enrdf_load_stackoverflow)
AR (1) AR031718A1 (enrdf_load_stackoverflow)
AT (1) ATE297921T1 (enrdf_load_stackoverflow)
AU (2) AU8399801A (enrdf_load_stackoverflow)
BR (1) BR0113312A (enrdf_load_stackoverflow)
CA (1) CA2419416C (enrdf_load_stackoverflow)
DE (1) DE60111540T2 (enrdf_load_stackoverflow)
DK (1) DK1311504T3 (enrdf_load_stackoverflow)
ES (1) ES2243541T3 (enrdf_load_stackoverflow)
MX (1) MXPA03001275A (enrdf_load_stackoverflow)
PA (1) PA8525201A1 (enrdf_load_stackoverflow)
PE (1) PE20020386A1 (enrdf_load_stackoverflow)
PT (1) PT1311504E (enrdf_load_stackoverflow)
UY (1) UY26885A1 (enrdf_load_stackoverflow)
WO (1) WO2002014312A1 (enrdf_load_stackoverflow)
ZA (1) ZA200300904B (enrdf_load_stackoverflow)

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Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
AU2003302279B2 (en) * 2002-10-03 2008-06-12 Novartis Ag Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of Type 2 diabetes
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
MY141521A (en) 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
AU2003294376A1 (en) * 2003-01-06 2004-08-10 Eli Lilly And Company Heteroaryl compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
US7262196B2 (en) * 2003-02-11 2007-08-28 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
CA2560689C (en) * 2004-04-02 2011-03-01 Novartis Ag Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful in the treatment of type 2 diabetes
EP1737870A1 (en) * 2004-04-02 2007-01-03 Novartis AG Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions
KR101346902B1 (ko) 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
MX2008000560A (es) 2005-07-11 2008-03-10 Mitsubishi Tanabe Pharma Corp Un derivado de oxima y sus preparaciones.
WO2007026761A1 (ja) 2005-08-31 2007-03-08 Astellas Pharma Inc. チアゾール誘導体
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
EP1931337B1 (en) 2005-09-29 2013-10-23 Sanofi Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
WO2007051845A1 (en) * 2005-11-03 2007-05-10 Prosidion Ltd Tricyclo substituted amides
US20070197532A1 (en) * 2005-11-18 2007-08-23 Cao Sheldon X Glucokinase activators
WO2007069684A1 (ja) * 2005-12-15 2007-06-21 Nihon Nohyaku Co., Ltd. フタルアミド誘導体及び農園芸用殺虫剤並びにその使用方法
JP5302012B2 (ja) 2006-03-08 2013-10-02 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
ATE522518T1 (de) * 2006-05-31 2011-09-15 Takeda San Diego Inc Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
US7910747B2 (en) * 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
EP2091947A2 (en) 2006-12-20 2009-08-26 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
US8314247B2 (en) * 2007-01-10 2012-11-20 Mitsubishi Tanabe Pharma Corporation Hydrazone derivative
US8034819B2 (en) * 2007-03-07 2011-10-11 Kyorin Pharmaceutical Co., Ltd. Glucokinase activator
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
WO2009047798A2 (en) * 2007-10-08 2009-04-16 Advinus Therapeutics Private Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
PE20091313A1 (es) * 2008-01-15 2009-09-03 Lilly Co Eli (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina
CN101918363B (zh) 2008-01-18 2012-09-05 安斯泰来制药株式会社 苯乙酰胺衍生物
PT2275414E (pt) * 2008-04-28 2015-09-09 Teijin Pharma Ltd Derivado de amida do ácido ciclopentacrílico
AU2011235212B2 (en) 2010-03-31 2014-07-31 The Scripps Research Institute Reprogramming cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
WO1998032753A1 (en) * 1997-01-28 1998-07-30 Merck & Co., Inc. THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
HUP0200396A3 (en) * 1999-03-29 2003-04-28 Hoffmann La Roche Gluckokinase activators, process for their preparation, pharmaceutical compositions containing them and their use

Also Published As

Publication number Publication date
AU2001283998B2 (en) 2005-10-20
US20020035267A1 (en) 2002-03-21
CA2419416A1 (en) 2002-02-21
CN1466584A (zh) 2004-01-07
JP2004506632A (ja) 2004-03-04
DK1311504T3 (da) 2005-10-17
KR20030022408A (ko) 2003-03-15
WO2002014312A1 (en) 2002-02-21
ATE297921T1 (de) 2005-07-15
US20020065275A1 (en) 2002-05-30
PA8525201A1 (es) 2002-07-30
EP1311504B1 (en) 2005-06-15
US6388088B1 (en) 2002-05-14
CA2419416C (en) 2009-10-13
AU8399801A (en) 2002-02-25
DE60111540D1 (de) 2005-07-21
JP3961948B2 (ja) 2007-08-22
DE60111540T2 (de) 2006-03-16
CN1209362C (zh) 2005-07-06
US20020035266A1 (en) 2002-03-21
KR100518061B1 (ko) 2005-09-28
ZA200300904B (en) 2004-04-30
US6369232B1 (en) 2002-04-09
EP1311504A1 (en) 2003-05-21
AR031718A1 (es) 2003-10-01
PT1311504E (pt) 2005-10-31
UY26885A1 (es) 2002-02-28
US6441180B1 (en) 2002-08-27
ES2243541T3 (es) 2005-12-01
BR0113312A (pt) 2003-07-01
MXPA03001275A (es) 2003-06-30

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed