PE20010480A1 - PRODUCTOS DE DROGAS ß-CARBOLINE - Google Patents
PRODUCTOS DE DROGAS ß-CARBOLINEInfo
- Publication number
- PE20010480A1 PE20010480A1 PE2000000773A PE0007732000A PE20010480A1 PE 20010480 A1 PE20010480 A1 PE 20010480A1 PE 2000000773 A PE2000000773 A PE 2000000773A PE 0007732000 A PE0007732000 A PE 0007732000A PE 20010480 A1 PE20010480 A1 PE 20010480A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- particles
- refers
- carboline
- diluents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
SE REFIERE A UNA FORMA PARTICULADA DE DROGA LIBRE DE UN COMPUESTO ß-CARBOLINE DE FORMULA I QUE COMPRENDE PARTICULAS DEL COMPUESTO DONDE AL MENOS 90% DE LAS PARTICULAS TIENEN UN TAMANO DE PARTICULA DE MENOS DE 40 MICRONES. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE UN COMPUESTO I; PORTADORES, DILUYENTES, EXCIPIENTES QUE MUESTRAN UNA CMAX DE 180µg/L A 280 µg/L USANDO UNA DOSIS DE 10 mg DE COMPUESTO. TAMBIEN SE REFIERE A UN METODO PARA LA ELABORACION DE LA FORMA PARTICULADA DE LA DROGA LIBRE QUE COMPRENDE PROPORCIONAR UNA FORMA LIBRE DEL COMPUESTO; PULVERIZAR LA FORMA LIBRE SOLIDA DEL COMPUESTO PARA PROPORCIONAR PARTICULAS DEL COMPUESTO DONDE AL MENOS EL 90% DE LAS PARTICULAS TIENE UN TAMANO DE PARTICULA DE MENOS DE 40 MICRONES; MEZCLAR LAS PARTICULAS CON DILUYENTES, EXCIPIENTES. EL COMPUESTO I ES UN INHIBIDOR DE 3`,5'-GUANOSINMONOFOSFATO FOSFODIESTERASA TIPO 5 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA DISFUNCION SEXUAL COMO ERECCION
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14704899P | 1999-08-03 | 1999-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010480A1 true PE20010480A1 (es) | 2001-05-26 |
Family
ID=22520112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000773A PE20010480A1 (es) | 1999-08-03 | 2000-08-03 | PRODUCTOS DE DROGAS ß-CARBOLINE |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP1200092B1 (es) |
| JP (1) | JP4456788B2 (es) |
| KR (1) | KR20020063842A (es) |
| CN (2) | CN1377270A (es) |
| AR (1) | AR033953A1 (es) |
| AT (1) | ATE264680T1 (es) |
| AU (1) | AU773666B2 (es) |
| BR (1) | BR0012901A (es) |
| CA (1) | CA2380087C (es) |
| CO (1) | CO5200849A1 (es) |
| CZ (1) | CZ300151B6 (es) |
| DE (1) | DE60010089T2 (es) |
| DK (1) | DK1200092T3 (es) |
| DZ (1) | DZ3180A1 (es) |
| EA (1) | EA004302B9 (es) |
| ES (1) | ES2220506T3 (es) |
| HK (1) | HK1044278B (es) |
| HR (1) | HRP20020091B1 (es) |
| HU (1) | HU229443B1 (es) |
| IL (1) | IL147642A0 (es) |
| MX (1) | MXPA02001197A (es) |
| MY (1) | MY125428A (es) |
| NO (1) | NO321602B1 (es) |
| NZ (1) | NZ516613A (es) |
| PE (1) | PE20010480A1 (es) |
| PL (1) | PL199469B1 (es) |
| PT (1) | PT1200092E (es) |
| SK (1) | SK286365B6 (es) |
| SV (1) | SV2002000137A (es) |
| TW (1) | TWI235658B (es) |
| UA (1) | UA71629C2 (es) |
| WO (1) | WO2001008688A2 (es) |
| ZA (1) | ZA200200825B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA004872B1 (ru) * | 1999-08-03 | 2004-08-26 | ЛИЛЛИ АЙКОС эЛ-эЛ-Си | β-КАРБОЛИНОВЫЕ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ |
| EP2216329A1 (en) * | 2004-10-28 | 2010-08-11 | Dr. Reddy's Laboratories Ltd. | Processes for the preparation of tadalafi |
| WO2007081366A1 (en) | 2006-01-05 | 2007-07-19 | Teva Pharmaceutical Industries Ltd. | Wet granulation pharmaceutical compositions of aripiprazole |
| DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| DE102009033396A1 (de) | 2009-07-16 | 2011-01-20 | Ratiopharm Gmbh | Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung |
| DE102009035211A1 (de) | 2009-07-29 | 2011-02-17 | Ratiopharm Gmbh | Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung |
| WO2012085927A2 (en) * | 2010-12-02 | 2012-06-28 | Mylan Laboratories, Limited | Tadalafil compositions |
| WO2012095151A1 (en) | 2010-12-23 | 2012-07-19 | Zaklady Farmaceutyczne Polpharma Sa | Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof |
| EP2672959A1 (en) | 2011-02-10 | 2013-12-18 | Synthon BV | Granulated composition comprising tadalafil and a disintegrant |
| RU2013141446A (ru) | 2011-02-10 | 2015-03-20 | Синтон Бв | Фармацевтическая композиция, содержащая тадалафил и циклодекстрин |
| WO2012107092A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
| JP5930686B2 (ja) * | 2011-12-07 | 2016-06-08 | 株式会社トクヤマ | 溶解性および安定性の向上した難溶性医薬品原体及びその製造方法 |
| KR20210068605A (ko) | 2012-03-15 | 2021-06-09 | 메르크 파텐트 게엠베하 | 전자 소자 |
| WO2014003678A1 (en) * | 2012-06-28 | 2014-01-03 | Xspray Microparticles Ab | Pharmaceutical compositions comprising ambrisentan and solid dispersion particles containing tadalafil |
| WO2014003677A1 (en) * | 2012-06-28 | 2014-01-03 | Xspray Microparticles Ab | Pharmaceutical compositions comprising solid dispersion particles containing tadalafil |
| CN105310984A (zh) * | 2014-06-10 | 2016-02-10 | 合肥贝霓医药科技有限公司 | 一种pde5抑制剂的超微粉体及其制备方法 |
| JP6445559B2 (ja) * | 2014-06-24 | 2018-12-26 | ウーシン ラボタチ カンパニー, リミテッドWooshin Labottach Co., Ltd. | タダラフィルを含む口腔内崩壊フィルム製剤およびその製造方法 |
| EP3466951B1 (en) | 2014-07-23 | 2022-01-19 | KRKA, d.d., Novo mesto | A process for the preparation of cgmp-phosphodiesterase inhibitor and oral pharmaceutical formulation comprising tadalafil co-precipitates |
| JP2016106139A (ja) * | 2016-03-07 | 2016-06-16 | 株式会社トクヤマ | 溶解性および安定性の向上した難溶性医薬品原体及びその製造方法 |
| WO2019130052A1 (en) * | 2017-12-26 | 2019-07-04 | Ftf Pharma Private Limited | Liquid oral formulations for pde v inhibitors |
| RS60973B1 (sr) | 2018-01-10 | 2020-11-30 | Gap S A | Meke želatinske kapsule koje sadrže suspenziju tadalafila |
| CN110638770B (zh) * | 2019-10-25 | 2022-04-05 | 株洲千金药业股份有限公司 | 他达拉非片剂的制备方法及以该方法制得的片剂 |
| WO2023227185A1 (en) * | 2022-05-27 | 2023-11-30 | Rontis Hellas S.A. | Improved pharmaceutical composition containing tadalafil and nanomilling process for the preparation thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618845A (en) * | 1994-10-06 | 1997-04-08 | Cephalon, Inc. | Acetamide derivative having defined particle size |
| GB9511220D0 (en) * | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
-
2000
- 2000-01-08 UA UA2002010773A patent/UA71629C2/uk unknown
- 2000-08-01 CZ CZ20020387A patent/CZ300151B6/cs not_active IP Right Cessation
- 2000-08-01 DE DE60010089T patent/DE60010089T2/de not_active Expired - Lifetime
- 2000-08-01 CN CN00813777A patent/CN1377270A/zh active Pending
- 2000-08-01 AU AU65084/00A patent/AU773666B2/en not_active Expired
- 2000-08-01 DZ DZ003180A patent/DZ3180A1/xx active
- 2000-08-01 BR BR0012901-1A patent/BR0012901A/pt not_active Application Discontinuation
- 2000-08-01 CA CA002380087A patent/CA2380087C/en not_active Expired - Lifetime
- 2000-08-01 DK DK00952371T patent/DK1200092T3/da active
- 2000-08-01 KR KR1020027001407A patent/KR20020063842A/ko active Search and Examination
- 2000-08-01 MX MXPA02001197A patent/MXPA02001197A/es active IP Right Grant
- 2000-08-01 EP EP00952371A patent/EP1200092B1/en not_active Expired - Lifetime
- 2000-08-01 ES ES00952371T patent/ES2220506T3/es not_active Expired - Lifetime
- 2000-08-01 AT AT00952371T patent/ATE264680T1/de active
- 2000-08-01 NZ NZ516613A patent/NZ516613A/en not_active IP Right Cessation
- 2000-08-01 WO PCT/US2000/020981 patent/WO2001008688A2/en active Search and Examination
- 2000-08-01 CN CNA2007101408018A patent/CN101134019A/zh active Pending
- 2000-08-01 IL IL14764200A patent/IL147642A0/xx active IP Right Grant
- 2000-08-01 EA EA200200119A patent/EA004302B9/ru not_active IP Right Cessation
- 2000-08-01 HU HU0202781A patent/HU229443B1/hu unknown
- 2000-08-01 SK SK172-2002A patent/SK286365B6/sk not_active IP Right Cessation
- 2000-08-01 JP JP2001513418A patent/JP4456788B2/ja not_active Expired - Lifetime
- 2000-08-01 PL PL353268A patent/PL199469B1/pl unknown
- 2000-08-01 PT PT00952371T patent/PT1200092E/pt unknown
- 2000-08-02 CO CO00058156A patent/CO5200849A1/es not_active Application Discontinuation
- 2000-08-02 MY MYPI20003524 patent/MY125428A/en unknown
- 2000-08-03 PE PE2000000773A patent/PE20010480A1/es not_active IP Right Cessation
- 2000-08-03 TW TW089115586A patent/TWI235658B/zh not_active IP Right Cessation
- 2000-08-03 AR ARP000104015A patent/AR033953A1/es not_active Application Discontinuation
- 2000-08-07 SV SV2000000137A patent/SV2002000137A/es unknown
-
2002
- 2002-01-29 HR HR20020091A patent/HRP20020091B1/xx not_active IP Right Cessation
- 2002-01-30 ZA ZA200200825A patent/ZA200200825B/en unknown
- 2002-02-01 NO NO20020531A patent/NO321602B1/no unknown
- 2002-06-19 HK HK02104540.5A patent/HK1044278B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| MK | Expiration of term |