PE20010049A1 - Bacteria que produce l-aminoacido y metodo para producir el l-aminoacido - Google Patents

Bacteria que produce l-aminoacido y metodo para producir el l-aminoacido

Info

Publication number
PE20010049A1
PE20010049A1 PE2000000315A PE0003152000A PE20010049A1 PE 20010049 A1 PE20010049 A1 PE 20010049A1 PE 2000000315 A PE2000000315 A PE 2000000315A PE 0003152000 A PE0003152000 A PE 0003152000A PE 20010049 A1 PE20010049 A1 PE 20010049A1
Authority
PE
Peru
Prior art keywords
amino acid
producing
aspartokinase
refers
homoserin
Prior art date
Application number
PE2000000315A
Other languages
English (en)
Inventor
Yoshiya Gunji
Hisashi Yasueda
Shinichi Sugimoto
Megumi Shimaoka
Nobuharu Tsujimoto
Yuri Miyata
Manami Oba
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of PE20010049A1 publication Critical patent/PE20010049A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Abstract

SE REFIERE A UNA BACTERIA METHYLOPHILUS DE PREFERENCIA METHYLOPHILUS METHYLOTROPHUS QUE TIENE CAPACIDAD DE PRODUCIR UN L-AMINOACIDO TAL COMO L-LISINA, L-VALINA, L-LEUCINA, L-ISOLEUCINA, L-TREONINA, SE CARACTERIZA POR PRESENTAR RESISTENCIA AL ANALOGO DEL L-AMINOACIDO O AUXOTROPIA DEL L-AMINOACIDO, POR LA ACTIVIDAD ENZIMATICA DE LA DIHIDRODIPICOLINATO SINTASA Y ASPARTOCINASA PARA LA BIOSINTESIS DEL L-AMINOACIDO ES MEJORADA MEDIANTE LA INTRODUCCION EN LAS CELULAS DE UN ADN EL CUAL NO SE INHIBE POR RETROALIMENTACION CON LISINA O SE MEJORA LA ACTIVIDAD DE LA SEMIALDEHIDO DE ACIDO ASPARTICO DESHIDROGENASA, DIHIDROPICOLINATO REDUCTASA, DIAMINOPIMELATO DESCARBOXILASA, ASPARTOCINASA, HOMOSERINA DESHIDROGENASA, HOMOSERINA CINASA, TREONINA SINTASA. TAMBIEN SE REFIERE A UN METODO PARA PRODUCIR EL L-AMINOACIDO; UN ADN QUE CODIFICA UNA PROTEINA DEFINIDA POR LA SECUENCIA SEC ID NO 6 DE 409 AMINOACIDOS; O LOS NUCLEOTIDOS 510 A 1736 DE LA SEC ID NO 5 DE 1981 BASES O DICHA PROTEINA INCLUYENDO SUSTITUCION, ELIMINACION, INSERCION, ADICION O INVERSION DE UNO O VARIOS AMINOACIDOS
PE2000000315A 1999-04-09 2000-04-07 Bacteria que produce l-aminoacido y metodo para producir el l-aminoacido PE20010049A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10314399 1999-04-09
JP16944799 1999-06-16
JP36809799 1999-12-24

Publications (1)

Publication Number Publication Date
PE20010049A1 true PE20010049A1 (es) 2001-02-26

Family

ID=27309903

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000315A PE20010049A1 (es) 1999-04-09 2000-04-07 Bacteria que produce l-aminoacido y metodo para producir el l-aminoacido

Country Status (11)

Country Link
US (3) US7223572B1 (es)
EP (1) EP1188822B1 (es)
JP (2) JP4273661B2 (es)
CN (2) CN1210396C (es)
AU (1) AU3674500A (es)
BR (1) BR0009550A (es)
DE (1) DE60033151T2 (es)
MX (1) MXPA01010151A (es)
PE (1) PE20010049A1 (es)
RU (4) RU2368659C2 (es)
WO (1) WO2000061723A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001120269A (ja) * 1999-10-22 2001-05-08 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
RU2202607C2 (ru) * 2000-03-03 2003-04-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм бактерий methylophilus methylotrophus - продуцент l-фенилаланина (варианты), способ получения l-фенилаланина
DE60219969T2 (de) * 2001-02-13 2008-01-17 Ajinomoto Co., Inc. Methode zur Production von L-Aminosäuren mittels Bakterien der Gattung Escherichia
DE60232120D1 (de) * 2001-06-12 2009-06-10 Ajinomoto Kk Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien
DE60324532D1 (de) * 2002-03-13 2008-12-18 Evonik Degussa Gmbh Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen der familie enterobacteriaceae
DE10210960A1 (de) * 2002-03-13 2003-09-25 Degussa Verfahren zur fermentativen Hestellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
US6911332B2 (en) 2002-06-12 2005-06-28 Ajinomoto Co., Inc. Isolated polynucleotides encoding d-arabino-3-hexulose-6-phosphate synthases from Methylophilus methylotrophus
JP2004166592A (ja) 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP4120364B2 (ja) 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたｌ−リジンまたはｌ−アルギニンの製造法
JP2004166595A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
DE102004001674B4 (de) * 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
JP2004236637A (ja) * 2003-02-10 2004-08-26 Ajinomoto Co Inc 多糖類生成に関与する遺伝子及びその利用
US7026149B2 (en) 2003-02-28 2006-04-11 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in the stress response to environmental changes in Methylophilus methylotrophus
US7060475B2 (en) 2003-02-28 2006-06-13 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in intermediates metabolism of central metabolic pathway in methylophilus methylotrophus
US7029893B2 (en) 2003-02-28 2006-04-18 Ajinomoto Co., Inc. Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus
RU2275424C2 (ru) * 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia
KR100786987B1 (ko) * 2004-01-30 2007-12-18 아지노모토 가부시키가이샤 Ｌ-아미노산 생산 미생물 및 ｌ-아미노산 생산 방법
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
EP2818554A3 (en) * 2004-10-07 2015-02-11 Ajinomoto Co., Inc. Method for producing a basic substance
JP2007185184A (ja) 2005-12-16 2007-07-26 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
BRPI0707229B8 (pt) 2006-01-27 2017-06-27 Ajinomoto Kk método para produzir um l-aminoácido
WO2007086618A1 (en) 2006-01-30 2007-08-02 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009089603A (ja) 2006-02-02 2009-04-30 Ajinomoto Co Inc メタノール資化性細菌を用いたｌ−リジンの製造法
JP2009153382A (ja) * 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法
BRPI0703692B1 (pt) * 2006-12-25 2016-12-27 Ajinomoto Kk método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores
JP2010088301A (ja) 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) * 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
KR20100120663A (ko) 2008-01-23 2010-11-16 아지노모토 가부시키가이샤 Ｌ-아미노산의 제조법
CN102471790B (zh) 2009-07-29 2014-10-29 味之素株式会社 产生l-氨基酸的方法
JP2012196144A (ja) 2009-08-03 2012-10-18 Ajinomoto Co Inc ビブリオ属細菌を用いたｌ−リジンの製造法
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
CN103667165B (zh) * 2012-09-12 2017-05-31 中国科学院上海生命科学研究院 高产l‑赖氨酸的生产菌株及其应用
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
WO2015109265A1 (en) * 2014-01-16 2015-07-23 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
JP7475866B2 (ja) * 2020-01-08 2024-04-30 花王株式会社 ２，５－ピリジンジカルボン酸類生産能を有する形質転換細胞
CN111607608B (zh) * 2020-04-20 2023-04-14 天津科技大学 基因工程高产菌株淀粉酶产色链霉菌及提高ε-聚赖氨酸产量的方法和应用
CN113214403B (zh) * 2021-04-25 2023-06-09 重庆威斯腾前沿生物研究院有限责任公司 一种链霉亲和素磁珠及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334987A (en) 1976-09-09 1978-03-31 Yoshiki Tani Production of llamino acid
FR2372439A1 (fr) * 1976-11-26 1978-06-23 Radiologie Cie Gle Detecteur de rayons x a scintillateur, et appareil de radiologie comportant de tels detecteurs
EP0035831B1 (en) 1980-03-07 1986-01-08 Imperial Chemical Industries Plc Method for making genetically modified microorganisms
NZ196643A (en) * 1980-03-28 1984-10-19 Ici Ltd Application of genetic engineering techniques to autotrophic or methylotrophic bacteria;composite plasmid derived from r300b
US4824786A (en) * 1984-09-14 1989-04-25 The Regents Of The University Of Minnesota Methylotroph cloning vehicle
WO1987002984A1 (en) * 1985-11-12 1987-05-21 American Biogenetics Corporation Biogenetic cassette
JPH01235595A (ja) * 1988-03-14 1989-09-20 Kyowa Hakko Kogyo Co Ltd 発酵法によるアミノ酸の製造法
US5268293A (en) * 1989-03-30 1993-12-07 Cheil Sugar Co., Ltd. Strain of Corynebacterium glutamicum and method for producing L-lysine
DE3943117A1 (de) 1989-12-27 1991-07-04 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen herstellung von aminosaeure, insbesondere l-lysin, dafuer geeignete mikroorganismen und rekombinante dna
JPH05207886A (ja) * 1992-01-29 1993-08-20 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−スレオニンの製造法
DE69330518T2 (de) * 1992-11-10 2002-05-08 Ajinomoto Kk Dna, die aspartokinase iii-mutanten kodiert und ihre verwendung zur herstellung von l-threonin durch fermentation
JPH07155184A (ja) 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
WO1996041871A1 (fr) * 1995-06-13 1996-12-27 Ajinomoto Co., Inc. Procede de production de l-lysine par fermentation
US5939307A (en) * 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JP4075087B2 (ja) * 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
JP2000166560A (ja) 1998-12-08 2000-06-20 Ajinomoto Co Inc 新規挿入配列
RU2202607C2 (ru) * 2000-03-03 2003-04-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм бактерий methylophilus methylotrophus - продуцент l-фенилаланина (варианты), способ получения l-фенилаланина
JP2004166592A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
JP2004166595A (ja) * 2002-11-20 2004-06-17 Ajinomoto Co Inc メチロトローフを用いたｌ−アミノ酸の製造法
DE102004001674B4 (de) * 2003-01-29 2019-01-24 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Lysin unter Einsatz von Methanol verwertenden Bakterien
JP2009153382A (ja) * 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法

Also Published As

Publication number Publication date
RU2004104198A (ru) 2005-07-20
AU3674500A (en) 2000-11-14
US7223572B1 (en) 2007-05-29
RU2334794C2 (ru) 2008-09-27
RU2004137825A (ru) 2006-06-10
JP2008295457A (ja) 2008-12-11
RU2351653C2 (ru) 2009-04-10
WO2000061723A1 (fr) 2000-10-19
EP1188822A4 (en) 2003-09-03
JP4273661B2 (ja) 2009-06-03
DE60033151D1 (de) 2007-03-15
CN1690191A (zh) 2005-11-02
BR0009550A (pt) 2002-02-05
CN1210396C (zh) 2005-07-13
RU2004137824A (ru) 2006-06-10
DE60033151T2 (de) 2007-11-15
US20130171700A1 (en) 2013-07-04
CN1346402A (zh) 2002-04-24
US20080038825A1 (en) 2008-02-14
MXPA01010151A (es) 2002-06-21
EP1188822B1 (en) 2007-01-24
RU2250266C2 (ru) 2005-04-20
RU2368659C2 (ru) 2009-09-27
EP1188822A1 (en) 2002-03-20

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