PE108198A1 - Lineas celulares inmortalizadas para el cultivo de virus - Google Patents
Lineas celulares inmortalizadas para el cultivo de virusInfo
- Publication number
- PE108198A1 PE108198A1 PE1997000704A PE00070497A PE108198A1 PE 108198 A1 PE108198 A1 PE 108198A1 PE 1997000704 A PE1997000704 A PE 1997000704A PE 00070497 A PE00070497 A PE 00070497A PE 108198 A1 PE108198 A1 PE 108198A1
- Authority
- PE
- Peru
- Prior art keywords
- cells
- viruses
- fibroblastes
- immortalized cells
- immortalized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/867—Retroviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16651—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE REFIEREN A CELULAS INMORTALIZADAS ESPONTANEAMENTE DE FIBROBLASTOS DE EMBRIONES DE POLLO EN CULTIVO, CON LAS CARACTERISTICAS DE UNA LINEA CELULAR UMNSAH-DF1, Y A LOS SUBCLONES DE ESTAS CELULAS INMORTALIZADAS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE CELULAS INMORTALIZADAS, QUE COMPRENDE: CULTIVAR FIBROBLASTOS PRIMARIOS DE EMBRIONES DE POLLO; TRASLADAR LOS FIBROBLASTOS EN CULTIVO HASTA QUE EMPIECE SU ENVEJECIMIENTO; CONCENTRAR LAS CELULAS DURANTE SU ENVEJECIMIENTO PARA MANTENERLAS ENTRE 30% A 60% EN EL CULTIVO; IDENTIFICAR Y AISLAR LOS FOCOS DE CELULAS NO ENVEJECIDAS; CULTIVAR LAS CELULAS NO ENVEJECIDAS EN MAS DE 30 PASOS. ADEMAS SE REFIERE AL PROCEDIMIENTO DE CULTIVO DE VIRUS EN CELULAS INMORTALIZADAS. LAS CELULAS INMORTALIZADAS ESPONTANEAMENTE SON RESERVORIOS LIBRES DE VIRUS CONTAMINANTES Y DE PROTEINA VIRAL, QUE FAVORECEN EL CULTIVO DEL VIRUS O LA EXPRESION DE LA PROTEINA O DEL VIRUS RECOMBINANTE, SIENDO UTILES PARA PRODUCIR VACUNAS PARA ANIMALES, ADEMAS PUEDEN SERVIR COMO SUSTRATO PARA APOYAR EL CRECIMIENTO DE VIRUS DE OTRAS CELULAS, QUE PERMITA LA PROPAGACION DEL VIRUS COMERCIALMENTE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/696,200 US5672485A (en) | 1996-08-13 | 1996-08-13 | Immortalized cell lines for virus growth |
Publications (1)
Publication Number | Publication Date |
---|---|
PE108198A1 true PE108198A1 (es) | 1999-01-21 |
Family
ID=24796108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000704A PE108198A1 (es) | 1996-08-13 | 1997-08-13 | Lineas celulares inmortalizadas para el cultivo de virus |
Country Status (29)
Country | Link |
---|---|
US (4) | US5672485A (es) |
EP (1) | EP0920491B1 (es) |
JP (3) | JP3754088B2 (es) |
KR (1) | KR100375871B1 (es) |
CN (1) | CN1228119B (es) |
AR (1) | AR008294A1 (es) |
AT (1) | ATE362524T1 (es) |
AU (1) | AU726820B2 (es) |
BR (1) | BR9711067A (es) |
CA (1) | CA2263725C (es) |
CO (1) | CO4700552A1 (es) |
DE (1) | DE69737735T2 (es) |
DK (1) | DK0920491T3 (es) |
DZ (1) | DZ2291A1 (es) |
ES (1) | ES2285738T3 (es) |
GT (1) | GT199700091A (es) |
HK (1) | HK1022496A1 (es) |
HN (1) | HN1997000124A (es) |
HU (1) | HU226658B1 (es) |
IL (4) | IL128511A (es) |
MA (1) | MA24303A1 (es) |
MY (1) | MY125594A (es) |
NZ (1) | NZ334147A (es) |
PE (1) | PE108198A1 (es) |
PT (1) | PT920491E (es) |
SV (1) | SV1997000071A (es) |
UY (1) | UY24668A1 (es) |
WO (1) | WO1998006824A1 (es) |
ZA (1) | ZA977216B (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672485A (en) * | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
US6150505A (en) * | 1997-09-19 | 2000-11-21 | Hadasit Medical Research Services & Development Ltd. | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII |
US6821741B1 (en) * | 2001-04-27 | 2004-11-23 | University Hospitals Of Cleveland | Cells for detection of enteroviruses |
US6552172B2 (en) | 2001-08-30 | 2003-04-22 | Habto Biotech, Inc. | Fibrin nanoparticles and uses thereof |
US20040023358A1 (en) * | 2001-12-21 | 2004-02-05 | Wyeth | Avian embryo particulate biomass for the production of virus antigens |
FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
US20090217404A1 (en) * | 2002-09-27 | 2009-08-27 | Lowe Scott W | Cell-based RNA interference and related methods and compositions |
WO2004031450A1 (ja) * | 2002-09-30 | 2004-04-15 | Honda Giken Kogyo Kabushiki Kaisha | 水素活性化装置 |
US20040170646A1 (en) * | 2002-12-13 | 2004-09-02 | Aventis Pasteur, Inc. | Production of ALVAC on avian embryonic stem cells |
US20090186839A1 (en) * | 2003-02-17 | 2009-07-23 | Cold Spring Harbor Laboratory | Model for studying the role of genes in chemoresistance |
WO2004074445A2 (en) * | 2003-02-17 | 2004-09-02 | Cold Spring Harbor Laboratory | Model for studying the role of genes in tumor resistance to chemotherapy |
US20050273873A1 (en) * | 2003-03-07 | 2005-12-08 | Avigenics, Inc. | Genomic modification |
US20040255345A1 (en) * | 2003-03-07 | 2004-12-16 | Rapp Jeffrey C. | Production of transgenic avians |
EP1608219A4 (en) * | 2003-03-07 | 2007-03-14 | Avigenics Inc | AVIAN TRANSGENESIS MEDIATED BY INTEGRASE |
US20050198700A1 (en) * | 2003-03-07 | 2005-09-08 | Avigenics, Inc. | Genomic modification |
US20050034186A1 (en) * | 2003-03-07 | 2005-02-10 | Harvey Alex J. | Site specific nucleic acid integration |
ATE467678T1 (de) | 2003-07-22 | 2010-05-15 | Vivalis | Produktion von poxviren mit adhärenten oder nicht adhärenten vogelzellinien |
WO2005028634A2 (en) * | 2003-09-18 | 2005-03-31 | Emory University | Improved mva vaccines |
EP1528101A1 (en) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
US20060123504A1 (en) * | 2004-12-07 | 2006-06-08 | Avigenics, Inc. | Methods of producing polyclonal antibodies |
US20060174364A1 (en) * | 2004-03-01 | 2006-08-03 | Avigenics, Inc. | Artificial chromosomes and transchromosomic avians |
WO2006042214A1 (en) * | 2004-10-08 | 2006-04-20 | Avigenics, Inc. | Modified integrase and methods of use |
US8137907B2 (en) * | 2005-01-03 | 2012-03-20 | Cold Spring Harbor Laboratory | Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof |
FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
EP1896587A2 (en) | 2005-05-31 | 2008-03-12 | Cold Spring Harbor Laboratory | METHODS FOR PRODUCING MICRORNAs |
US7524626B2 (en) * | 2005-10-05 | 2009-04-28 | Synageva Biopharma Corp. | Rapid production of high titer virus |
RU2489486C2 (ru) | 2006-06-20 | 2013-08-10 | Трансжене С.А. | Процесс получения поксвирусов и композиции поксвирусов |
CN100443588C (zh) * | 2006-12-11 | 2008-12-17 | 中国农业科学院北京畜牧兽医研究所 | 静宁鸡胚成纤维细胞系及其培养方法 |
US8213704B2 (en) * | 2007-05-09 | 2012-07-03 | Kla-Tencor Corp. | Methods and systems for detecting defects in a reticle design pattern |
EP2014279A1 (en) * | 2007-06-22 | 2009-01-14 | Pevion Biotech AG | Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof |
ES2618490T3 (es) | 2007-07-03 | 2017-06-21 | Transgene Sa | Estirpes celulares aviares inmortalizadas |
US8357531B2 (en) | 2007-07-03 | 2013-01-22 | Transgene S.A. | Immortalized avian cell lines |
US8901288B2 (en) * | 2007-10-26 | 2014-12-02 | Cold Spring Harbor Laboratory | High throughput methods for functionally determining RNA interference efficiency |
EP2257622B1 (en) | 2008-02-25 | 2017-03-22 | Nanotherapeutics, Inc. | Method for producing continuous cell lines |
RU2560976C2 (ru) | 2009-05-12 | 2015-08-20 | Трансген Са | Способ продуцирования и очистки ортопоксвируса |
WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
AU2011281982B2 (en) | 2010-07-20 | 2015-12-17 | Bavarian Nordic A/S | Method for harvesting expression products |
FR3008992A1 (fr) * | 2013-07-25 | 2015-01-30 | Agronomique Inst Nat Rech | Procede de selection d'une lignee cellulaire permissive pour la replication de virus aviaires |
MX2017007178A (es) | 2014-12-01 | 2017-08-28 | Transgene Sa | Formulaciones liquidas estables de virus de vacuna. |
BR112017011582A2 (pt) | 2014-12-04 | 2018-02-27 | Intervet Int Bv | fibroblasto de embrião de galinha imortalizado, cultura de célula, métodos para preparação de um cef importalizado, para a replicação de um vetor viral aviário e para a preparação de uma vacina, e, vacina. |
KR101768581B1 (ko) * | 2015-08-13 | 2017-08-17 | 전북대학교 산학협력단 | 자발적 불멸화된 체세포의 단일 세포로부터 리프로그래밍 세포주의 제조방법 |
EP3387113A1 (en) * | 2015-12-11 | 2018-10-17 | Intervet International B.V. | Immortalised chicken embryonic epithelial kidney cells |
EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
WO2018093903A1 (en) | 2016-11-17 | 2018-05-24 | Regents Of The University Of Minnesota | Immortalized cell lines and methods of use |
CA3061678A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
CA3062549A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
JP7334124B2 (ja) | 2017-06-21 | 2023-08-28 | トランジェーヌ | 個別化ワクチン |
CN107858323B (zh) * | 2017-11-08 | 2020-10-09 | 广东省生物资源应用研究所 | 一种红耳龟胚胎成纤维细胞系及其构建方法 |
CN109234239B (zh) * | 2018-07-13 | 2021-09-14 | 广东永顺生物制药股份有限公司 | 一种鸭瘟病毒的培养方法 |
WO2020049151A1 (en) | 2018-09-06 | 2020-03-12 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
BR112022010825A2 (pt) | 2019-12-20 | 2022-08-23 | Intervet Int Bv | Vacina de vetor hvt multivalente |
BR112022017438A2 (pt) | 2020-03-12 | 2022-10-18 | Bavarian Nordic As | Composições que melhoram a estabilidade do poxvírus |
AU2021309007A1 (en) | 2020-07-13 | 2023-02-16 | Transgene | Treatment of immune depression |
US20240024456A1 (en) | 2020-09-07 | 2024-01-25 | Intervet Inc. | Ha stem vaccine for ha antibody-positive targets |
CN116648259A (zh) | 2020-12-24 | 2023-08-25 | 英特维特国际股份有限公司 | 多价hvt载体疫苗 |
EP4370150A1 (en) | 2021-07-13 | 2024-05-22 | Intervet International B.V. | Overcoming antibody-interference in avians |
WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
WO2023213946A1 (en) | 2022-05-05 | 2023-11-09 | Intervet International B.V. | New multivalent hvt vector vaccine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3058438B2 (ja) * | 1990-10-19 | 2000-07-04 | 財団法人化学及血清療法研究所 | ヒト肝臓組織特異的ウイルスの感染可能な霊長類の不死化肝細胞およびその調製方法 |
US5672485A (en) * | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
-
1996
- 1996-08-13 US US08/696,200 patent/US5672485A/en not_active Expired - Lifetime
-
1997
- 1997-08-12 GT GT199700091A patent/GT199700091A/es unknown
- 1997-08-12 MA MA24765A patent/MA24303A1/fr unknown
- 1997-08-12 ZA ZA9707216A patent/ZA977216B/xx unknown
- 1997-08-12 MY MYPI97003686A patent/MY125594A/en unknown
- 1997-08-13 PE PE1997000704A patent/PE108198A1/es not_active Application Discontinuation
- 1997-08-13 DZ DZ970141A patent/DZ2291A1/fr active
- 1997-08-13 IL IL12851197A patent/IL128511A/en not_active IP Right Cessation
- 1997-08-13 CO CO97046519A patent/CO4700552A1/es unknown
- 1997-08-13 BR BR9711067A patent/BR9711067A/pt active Search and Examination
- 1997-08-13 UY UY24668A patent/UY24668A1/es not_active IP Right Cessation
- 1997-08-13 KR KR10-1999-7001214A patent/KR100375871B1/ko not_active IP Right Cessation
- 1997-08-13 CA CA002263725A patent/CA2263725C/en not_active Expired - Lifetime
- 1997-08-13 IL IL15830397A patent/IL158303A0/xx not_active IP Right Cessation
- 1997-08-13 DE DE69737735T patent/DE69737735T2/de not_active Expired - Lifetime
- 1997-08-13 WO PCT/US1997/014384 patent/WO1998006824A1/en active IP Right Grant
- 1997-08-13 AR ARP970103696A patent/AR008294A1/es active IP Right Grant
- 1997-08-13 DK DK97938334T patent/DK0920491T3/da active
- 1997-08-13 SV SV1997000071A patent/SV1997000071A/es active IP Right Grant
- 1997-08-13 CN CN971972818A patent/CN1228119B/zh not_active Expired - Lifetime
- 1997-08-13 ES ES97938334T patent/ES2285738T3/es not_active Expired - Lifetime
- 1997-08-13 HU HU0000188A patent/HU226658B1/hu unknown
- 1997-08-13 EP EP97938334A patent/EP0920491B1/en not_active Expired - Lifetime
- 1997-08-13 NZ NZ334147A patent/NZ334147A/xx not_active IP Right Cessation
- 1997-08-13 JP JP51005398A patent/JP3754088B2/ja not_active Expired - Lifetime
- 1997-08-13 PT PT97938334T patent/PT920491E/pt unknown
- 1997-08-13 IL IL15830197A patent/IL158301A0/xx not_active IP Right Cessation
- 1997-08-13 AT AT97938334T patent/ATE362524T1/de active
- 1997-08-13 AU AU40691/97A patent/AU726820B2/en not_active Expired
- 1997-08-13 IL IL15830297A patent/IL158302A0/xx not_active IP Right Cessation
- 1997-08-26 HN HN1997000124A patent/HN1997000124A/es unknown
- 1997-09-30 US US08/941,849 patent/US5879924A/en not_active Expired - Lifetime
-
1998
- 1998-09-11 US US09/151,718 patent/US5985642A/en not_active Expired - Lifetime
-
1999
- 1999-09-30 US US09/409,521 patent/US6207415B1/en not_active Expired - Lifetime
-
2000
- 2000-03-03 HK HK00101387.9A patent/HK1022496A1/xx not_active IP Right Cessation
-
2005
- 2005-01-19 JP JP2005011481A patent/JP2005118053A/ja active Pending
-
2006
- 2006-06-28 JP JP2006178683A patent/JP2006320328A/ja active Pending
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