OA11449A - Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins. - Google Patents

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins. Download PDF

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Publication number
OA11449A
OA11449A OA1200000217A OA1200000217A OA11449A OA 11449 A OA11449 A OA 11449A OA 1200000217 A OA1200000217 A OA 1200000217A OA 1200000217 A OA1200000217 A OA 1200000217A OA 11449 A OA11449 A OA 11449A
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OA
OAPI
Prior art keywords
leu
ala
val
gly
avec
Prior art date
Application number
OA1200000217A
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English (en)
Inventor
Kim Jonelle Stutzman-Engwall
Yoshihiro Katoh
Hamish Alastair Irvin Mcarthur
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11449A publication Critical patent/OA11449A/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
OA1200000217A 1998-02-13 2000-08-04 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins. OA11449A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13

Publications (1)

Publication Number Publication Date
OA11449A true OA11449A (en) 2003-12-03

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200000217A OA11449A (en) 1998-02-13 2000-08-04 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins.

Country Status (32)

Country Link
EP (1) EP1053335A1 (is)
JP (2) JP2002503473A (is)
KR (3) KR100499214B1 (is)
CN (2) CN1297485A (is)
AP (1) AP9901463A0 (is)
AR (1) AR018085A1 (is)
AU (1) AU752343C (is)
BG (1) BG64911B1 (is)
BR (1) BR9907893A (is)
CA (2) CA2521289A1 (is)
CO (1) CO5070698A1 (is)
DZ (1) DZ2720A1 (is)
EA (1) EA003905B1 (is)
GT (1) GT199900014A (is)
HN (1) HN1999000008A (is)
HR (1) HRP20000539A2 (is)
HU (1) HUP0100784A3 (is)
IL (2) IL137610A0 (is)
IS (1) IS5567A (is)
MA (1) MA24760A1 (is)
NO (1) NO20004044L (is)
NZ (2) NZ505676A (is)
OA (1) OA11449A (is)
PA (1) PA8467601A1 (is)
PE (1) PE20000352A1 (is)
PL (1) PL194270B1 (is)
SK (1) SK11722000A3 (is)
TN (1) TNSN99017A1 (is)
TW (1) TW585910B (is)
WO (1) WO1999041389A1 (is)
YU (1) YU50900A (is)
ZA (1) ZA991138B (is)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
CN1297485A (zh) * 1998-02-13 2001-05-30 辉瑞产品公司 介导除虫菌素b2:b1比例的除虫链霉菌基因
IL147563A0 (en) * 1999-08-12 2002-08-14 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
ES2373629T3 (es) 2002-02-12 2012-02-07 Pfizer Products Inc. Gen de streptomyces avemitilis que dirige la proporción de avermectinas b2:b1.
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (is) * 1987-01-23 1991-01-19 Pfizer
EP0313297B1 (en) * 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725A (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
CN1297485A (zh) * 1998-02-13 2001-05-30 辉瑞产品公司 介导除虫菌素b2:b1比例的除虫链霉菌基因

Also Published As

Publication number Publication date
YU50900A (sh) 2004-03-12
TW585910B (en) 2004-05-01
NZ518657A (en) 2003-10-31
IL137610A0 (en) 2001-07-24
PL194270B1 (pl) 2007-05-31
JP2004283174A (ja) 2004-10-14
PL342468A1 (en) 2001-06-04
HRP20000539A2 (en) 2001-04-30
NZ505676A (en) 2003-02-28
EP1053335A1 (en) 2000-11-22
HUP0100784A3 (en) 2004-10-28
GT199900014A (es) 2000-07-25
WO1999041389A1 (en) 1999-08-19
ZA991138B (en) 2000-08-14
KR20040053390A (ko) 2004-06-23
CO5070698A1 (es) 2001-08-28
PE20000352A1 (es) 2000-05-16
CA2521289A1 (en) 1999-08-19
AR018085A1 (es) 2001-10-31
BG64911B1 (bg) 2006-08-31
AU1887899A (en) 1999-08-30
DZ2720A1 (fr) 2003-09-01
PA8467601A1 (es) 2000-09-29
AU752343C (en) 2005-11-03
EA003905B1 (ru) 2003-10-30
HUP0100784A2 (hu) 2001-06-28
NO20004044L (no) 2000-10-11
JP2002503473A (ja) 2002-02-05
CN1521180A (zh) 2004-08-18
AU752343B2 (en) 2002-09-19
BR9907893A (pt) 2000-11-14
TNSN99017A1 (fr) 2005-11-10
BG104759A (en) 2001-04-30
JP4011036B2 (ja) 2007-11-21
CN1297485A (zh) 2001-05-30
CA2320031A1 (en) 1999-08-19
KR20010052166A (ko) 2001-06-25
MA24760A1 (fr) 1999-10-01
IS5567A (is) 2000-07-20
NO20004044D0 (no) 2000-08-11
AP9901463A0 (en) 1999-03-31
IL183596A0 (is) 2007-09-20
KR20040099389A (ko) 2004-11-26
KR100499214B1 (ko) 2005-07-07
EA200000758A1 (ru) 2001-04-23
HN1999000008A (es) 1999-10-29
SK11722000A3 (sk) 2001-04-09

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