OA11162A - Pellets having a core coated with an antifungal and a polymer - Google Patents
Pellets having a core coated with an antifungal and a polymer Download PDFInfo
- Publication number
- OA11162A OA11162A OA9900215A OA9900215A OA11162A OA 11162 A OA11162 A OA 11162A OA 9900215 A OA9900215 A OA 9900215A OA 9900215 A OA9900215 A OA 9900215A OA 11162 A OA11162 A OA 11162A
- Authority
- OA
- OAPI
- Prior art keywords
- coating
- percent
- pellets
- itraconazole
- seal
- Prior art date
Links
- 239000008188 pellet Substances 0.000 title claims abstract description 57
- 229940121375 antifungal agent Drugs 0.000 title claims abstract description 22
- 230000000843 anti-fungal effect Effects 0.000 title claims description 5
- 229920000642 polymer Polymers 0.000 title description 11
- 238000000576 coating method Methods 0.000 claims abstract description 36
- 239000011248 coating agent Substances 0.000 claims abstract description 23
- 239000002552 dosage form Substances 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 20
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 20
- 239000003429 antifungal agent Substances 0.000 claims abstract description 15
- 235000000346 sugar Nutrition 0.000 claims abstract description 13
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 45
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 43
- 229960004130 itraconazole Drugs 0.000 claims description 43
- 229940079593 drug Drugs 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 35
- 239000011162 core material Substances 0.000 claims description 31
- 238000005507 spraying Methods 0.000 claims description 20
- -1 hydroxypropyl Chemical group 0.000 claims description 14
- 229920001688 coating polymer Polymers 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 239000007903 gelatin capsule Substances 0.000 claims description 7
- HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 claims description 6
- 229950005137 saperconazole Drugs 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 5
- 229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 claims description 4
- SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000011247 coating layer Substances 0.000 abstract description 10
- 239000000243 solution Substances 0.000 description 26
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 22
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 22
- 239000000203 mixture Substances 0.000 description 22
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 21
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 20
- 239000002775 capsule Substances 0.000 description 14
- 229940073584 methylene chloride Drugs 0.000 description 13
- 238000004090 dissolution Methods 0.000 description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000011324 bead Substances 0.000 description 9
- 239000010410 layer Substances 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000000314 lubricant Substances 0.000 description 7
- 239000000546 pharmaceutical excipient Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000003086 colorant Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 206010017533 Fungal infection Diseases 0.000 description 5
- 208000031888 Mycoses Diseases 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
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- 230000000694 effects Effects 0.000 description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 5
- 239000008108 microcrystalline cellulose Substances 0.000 description 5
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- 239000002245 particle Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 4
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
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- 239000011780 sodium chloride Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 239000012738 dissolution medium Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 229940088679 drug related substance Drugs 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
- 239000006186 oral dosage form Substances 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
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- 235000010356 sorbitol Nutrition 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- 229930195725 Mannitol Natural products 0.000 description 2
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- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
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- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97200914 | 1997-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11162A true OA11162A (en) | 2003-04-16 |
Family
ID=8228147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA9900215A OA11162A (en) | 1997-03-26 | 1999-09-24 | Pellets having a core coated with an antifungal and a polymer |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0969821B1 (pl) |
| JP (1) | JP3608800B2 (pl) |
| KR (1) | KR100520936B1 (pl) |
| CN (1) | CN1206984C (pl) |
| AP (1) | AP1227A (pl) |
| AT (1) | ATE241969T1 (pl) |
| AU (1) | AU734248B2 (pl) |
| BG (1) | BG64434B1 (pl) |
| BR (1) | BR9806174A (pl) |
| CA (1) | CA2269501C (pl) |
| CY (1) | CY2384B1 (pl) |
| CZ (1) | CZ295502B6 (pl) |
| DE (1) | DE69815316T2 (pl) |
| DK (1) | DK0969821T3 (pl) |
| EE (1) | EE03904B1 (pl) |
| ES (1) | ES2201485T3 (pl) |
| HK (1) | HK1022840A1 (pl) |
| HU (1) | HU224217B1 (pl) |
| ID (1) | ID21477A (pl) |
| IL (1) | IL129575A (pl) |
| NO (1) | NO325102B1 (pl) |
| NZ (1) | NZ335364A (pl) |
| OA (1) | OA11162A (pl) |
| PL (1) | PL190566B1 (pl) |
| PT (1) | PT969821E (pl) |
| RU (1) | RU2218153C2 (pl) |
| SI (1) | SI0969821T1 (pl) |
| SK (1) | SK284813B6 (pl) |
| TR (1) | TR199900990T2 (pl) |
| UA (1) | UA60318C2 (pl) |
| WO (1) | WO1998042318A1 (pl) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100549095B1 (ko) * | 1998-07-17 | 2006-02-06 | 얀센 파마슈티카 엔.브이. | 항진균제 및 중합체로 코팅된 코어를 갖는 펠릿 |
| ES2157731B1 (es) | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
| CN1156461C (zh) | 1999-03-24 | 2004-07-07 | R·P·希拉技术股份有限公司 | 改良的水溶性药物制剂 |
| KR100432949B1 (ko) * | 2000-06-13 | 2004-05-31 | 코오롱제약주식회사 | 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법 |
| US6663897B2 (en) * | 2001-02-06 | 2003-12-16 | Dsm Ip Assets B.V. | Oral itraconazole formulations and methods of making the same |
| IL157171A0 (en) | 2001-02-14 | 2004-02-08 | Tibotec Pharm Ltd | Broadspectrum 2-(substituted-amino) -benzothiazole sulfonamide hiv protease inhibitors |
| JP4417010B2 (ja) | 2001-04-09 | 2010-02-17 | テイボテク・フアーマシユーチカルズ・リミテツド | 広範囲２−（置換−アミノ）−ベンズオキサゾールスルホンアミドｈｉｖプロテアーゼ阻害剤 |
| CA2444895C (en) | 2001-05-11 | 2011-02-15 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors |
| WO2002100407A1 (en) * | 2001-06-12 | 2002-12-19 | Smartrix Technologies Inc. | Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same |
| US8071133B2 (en) | 2001-08-20 | 2011-12-06 | Stiefel Laboratories, Inc. | Oral dosage forms of water insoluble drugs and methods of making the same |
| PL216539B1 (pl) | 2001-12-21 | 2014-04-30 | Tibotec Pharm Ltd | Związki fenylosulfonylowe i zastosowanie związków fenylosulfonylowych |
| MY142238A (en) | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
| NZ536496A (en) | 2002-05-17 | 2006-06-30 | Tibotec Pharm Ltd | Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors |
| KR100994759B1 (ko) | 2002-08-14 | 2010-11-16 | 티보텍 파마슈티컬즈 | 광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제 |
| KR100557680B1 (ko) * | 2002-11-23 | 2006-03-07 | 한국유나이티드제약 주식회사 | 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법 |
| EP1438960B2 (en) * | 2003-01-14 | 2012-12-19 | Acino Pharma AG | Compostion of itraconazole dispersed in a hydrophilic polymer having enhanced bioavailability |
| EP1438961B2 (en) * | 2003-01-14 | 2014-08-20 | Acino Pharma AG | Bioequivalent composition of itraconazole dispersed in a hydrophilic polymer |
| JP2007501256A (ja) | 2003-08-06 | 2007-01-25 | ムルイェ、ニルマル | 水溶性薬物を含有する医薬組成物 |
| SG145742A1 (en) | 2003-09-11 | 2008-09-29 | Tibotec Pharm Ltd | Entry inhibitors of the hiv virus |
| EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
| AR048650A1 (es) | 2004-05-04 | 2006-05-10 | Tibotec Pharm Ltd | Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih |
| JP5073480B2 (ja) | 2004-05-07 | 2012-11-14 | セコイア、ファーマシューティカルズ、インコーポレイテッド | 耐性防止レトロウイルスプロテアーゼ阻害薬 |
| TW200613307A (en) | 2004-05-17 | 2006-05-01 | Tibotec Pharm Ltd | 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones |
| ATE481403T1 (de) | 2004-05-17 | 2010-10-15 | Tibotec Pharm Ltd | Substituierte 1-phenyl-1,5-dihydro-pyridoä3,2- büindol-2-on-derivate verwendbar als pharmazeutische antiinfektiva |
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| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
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| PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| AU731704B2 (en) * | 1996-06-28 | 2001-04-05 | Schering Corporation | Oral composition comprising a triazole antifungal compound |
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1998
- 1998-03-18 RU RU99112123/15A patent/RU2218153C2/ru active
- 1998-03-18 CA CA002269501A patent/CA2269501C/en not_active Expired - Lifetime
- 1998-03-18 WO PCT/EP1998/001773 patent/WO1998042318A1/en active IP Right Grant
- 1998-03-18 CN CNB988020181A patent/CN1206984C/zh not_active Expired - Lifetime
- 1998-03-18 PT PT98919155T patent/PT969821E/pt unknown
- 1998-03-18 HU HU0002056A patent/HU224217B1/hu active IP Right Grant
- 1998-03-18 JP JP54490198A patent/JP3608800B2/ja not_active Expired - Lifetime
- 1998-03-18 SK SK544-99A patent/SK284813B6/sk not_active IP Right Cessation
- 1998-03-18 AP APAP/P/1999/001516A patent/AP1227A/en active
- 1998-03-18 UA UA99042468A patent/UA60318C2/uk unknown
- 1998-03-18 CZ CZ19991398A patent/CZ295502B6/cs not_active IP Right Cessation
- 1998-03-18 DE DE69815316T patent/DE69815316T2/de not_active Expired - Lifetime
- 1998-03-18 AT AT98919155T patent/ATE241969T1/de active
- 1998-03-18 BR BR9806174-7A patent/BR9806174A/pt not_active Application Discontinuation
- 1998-03-18 ID IDW990316A patent/ID21477A/id unknown
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- 1998-03-18 DK DK98919155T patent/DK0969821T3/da active
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- 1998-03-18 SI SI9830489T patent/SI0969821T1/xx unknown
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- 1998-03-18 KR KR10-1999-7003848A patent/KR100520936B1/ko not_active IP Right Cessation
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2000
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