EE03904B1 - Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid - Google Patents

Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Info

Publication number
EE03904B1
EE03904B1 EEP199900453A EEP9900453A EE03904B1 EE 03904 B1 EE03904 B1 EE 03904B1 EE P199900453 A EEP199900453 A EE P199900453A EE P9900453 A EEP9900453 A EE P9900453A EE 03904 B1 EE03904 B1 EE 03904B1
Authority
EE
Estonia
Prior art keywords
granules
granule
drug
preparation
dosage form
Prior art date
Application number
EEP199900453A
Other languages
English (en)
Estonian (et)
Inventor
Florent Victor De Cond Valentin
Petrus Gerebern Vandecruys Roger
Marie Victor Gilis Paul
Peeters Jozef
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9900453A publication Critical patent/EE9900453A/xx
Publication of EE03904B1 publication Critical patent/EE03904B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EEP199900453A 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid EE03904B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number Publication Date
EE9900453A EE9900453A (et) 2000-04-17
EE03904B1 true EE03904B1 (et) 2002-12-16

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900453A EE03904B1 (et) 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Country Status (31)

Country Link
EP (1) EP0969821B1 (pl)
JP (1) JP3608800B2 (pl)
KR (1) KR100520936B1 (pl)
CN (1) CN1206984C (pl)
AP (1) AP1227A (pl)
AT (1) ATE241969T1 (pl)
AU (1) AU734248B2 (pl)
BG (1) BG64434B1 (pl)
BR (1) BR9806174A (pl)
CA (1) CA2269501C (pl)
CY (1) CY2384B1 (pl)
CZ (1) CZ295502B6 (pl)
DE (1) DE69815316T2 (pl)
DK (1) DK0969821T3 (pl)
EE (1) EE03904B1 (pl)
ES (1) ES2201485T3 (pl)
HK (1) HK1022840A1 (pl)
HU (1) HU224217B1 (pl)
ID (1) ID21477A (pl)
IL (1) IL129575A (pl)
NO (1) NO325102B1 (pl)
NZ (1) NZ335364A (pl)
OA (1) OA11162A (pl)
PL (1) PL190566B1 (pl)
PT (1) PT969821E (pl)
RU (1) RU2218153C2 (pl)
SI (1) SI0969821T1 (pl)
SK (1) SK284813B6 (pl)
TR (1) TR199900990T2 (pl)
UA (1) UA60318C2 (pl)
WO (1) WO1998042318A1 (pl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1104291B1 (en) * 1998-07-17 2005-09-07 Janssen Pharmaceutica N.V. Pellets having a core coated with an antifungal and a polymer
ES2157731B1 (es) 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
DE60023465T2 (de) 1999-03-24 2006-07-20 R.P. Scherer Technologies, Inc., Las Vegas Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
ATE343567T1 (de) 2001-02-14 2006-11-15 Tibotec Pharm Ltd Breitspektrum 2-(substituierte-amino)- benzothiazol-sulfonamide hiv protease inhibitoren
PL367084A1 (pl) 2001-04-09 2005-02-21 Tibotec Pharmaceuticals Ltd. Sulfonoamidy 2-(podstawionego-amino) benzoksazolujako inhibitory proteazy HIV o szerokim zakresie działania
AU2002310818B2 (en) 2001-05-11 2007-12-13 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
AU2002317063A (en) * 2001-06-12 2002-12-23 Smartrix Technologies Inc Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
HUP0500164A3 (en) 2001-12-21 2009-03-30 Tibotec Pharm Ltd Heterocyclic substituted benzenesulfonamides as hiv protease inhibitors and pharmaceutical compositions containing them
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
PL373425A1 (pl) 2002-05-17 2005-08-22 Tibotec Pharmaceuticals Ltd. Podstawione benzoizoksazolosulfonoamidy jako inhibitory proteaz HIV o szerokim spektrum działania
KR100994759B1 (ko) 2002-08-14 2010-11-16 티보텍 파마슈티컬즈 광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
ATE357235T1 (de) * 2003-01-14 2007-04-15 Cimex Pharma Ag Bioaequivalente zusammensetzung in der form einer festen dispersion enthaltend itraconazol und ein hydrophiles polymer
DK1438960T4 (da) * 2003-01-14 2013-03-25 Cimex Pharma Ag Sammensætning af itraconazol dispergeret i en hydrofil polymer med forhøjet biotilgængelighed
US7897179B2 (en) * 2003-08-06 2011-03-01 Nostrum Pharmaceuticals, Inc. Pharmaceutical composition containing water soluble drug
MXPA06002780A (es) 2003-09-11 2006-06-14 Tibotec Pharm Ltd Inhibidores de entrada del virus de vih.
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
CA2566340C (en) 2004-05-07 2014-05-06 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
WO2005111047A1 (en) 2004-05-17 2005-11-24 Tibotec Pharmaceuticals Ltd. 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones
TW200613307A (en) 2004-05-17 2006-05-01 Tibotec Pharm Ltd 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
TW200607502A (en) 2004-05-17 2006-03-01 Tibotec Pharm Ltd 6, 7, 8, 9-substituted 1-phenyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones
JP2009534311A (ja) 2006-04-03 2009-09-24 テイボテク・フアーマシユーチカルズ・リミテツド ＨＩＶ阻害性３，４−ジヒドロ−イミダゾ［４，５−ｂ］ピリジン−５−オン
EP2068844A4 (en) * 2006-09-04 2013-01-23 Panacea Biotec Ltd PROGRAMMABLE RELEASE TECHNIQUE BY FLOATING SYSTEM
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
CN101965186A (zh) 2007-11-28 2011-02-02 塞阔伊亚药品公司 抑制细胞色素p450 2d6的化合物和方法
CA2716348C (en) 2008-02-21 2017-04-04 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome p450
US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US8877822B2 (en) 2010-09-28 2014-11-04 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
CA2799201C (en) * 2010-05-11 2016-09-20 Allergan, Inc. Porogen compositions, methods of making and uses
US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
CN102100678B (zh) * 2011-02-18 2012-10-17 天津力生制药股份有限公司 伊曲康唑硫酸盐微丸及其制备方法
EP2931490A1 (en) 2012-12-13 2015-10-21 Allergan, Inc. Device and method for making a variable surface breast implant
US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
KR102495757B1 (ko) 2016-01-20 2023-02-06 테라비다, 인코포레이티드 다한증을 치료하기 위한 방법 및 조성물
BR112020020941A2 (pt) * 2018-04-16 2021-03-02 Bristol-Myers Squibb Company formulações apixaban
CN114767636B (zh) * 2022-04-11 2023-11-07 苏州中化药品工业有限公司 伊曲康唑微丸、制备方法及伊曲康唑微丸胶囊

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
AU731704B2 (en) * 1996-06-28 2001-04-05 Schering Corporation Oral composition comprising a triazole antifungal compound

Also Published As

Publication number Publication date
PL190566B1 (pl) 2005-12-30
EP0969821B1 (en) 2003-06-04
BG103356A (en) 2000-03-31
NO992114D0 (no) 1999-04-30
SI0969821T1 (en) 2003-10-31
AP9901516A0 (en) 1999-06-30
JP3608800B2 (ja) 2005-01-12
AP1227A (en) 2003-11-24
RU2218153C2 (ru) 2003-12-10
CZ139899A3 (cs) 1999-10-13
NZ335364A (en) 2000-08-25
HK1022840A1 (en) 2000-08-25
TR199900990T2 (xx) 1999-10-21
EE9900453A (et) 2000-04-17
IL129575A (en) 2004-06-20
PL335542A1 (en) 2000-04-25
DE69815316T2 (de) 2004-04-29
JP2001520663A (ja) 2001-10-30
BR9806174A (pt) 1999-10-19
ATE241969T1 (de) 2003-06-15
OA11162A (en) 2003-04-16
AU7210798A (en) 1998-10-20
KR100520936B1 (ko) 2005-10-17
AU734248B2 (en) 2001-06-07
HU224217B1 (hu) 2005-06-28
CN1206984C (zh) 2005-06-22
UA60318C2 (uk) 2003-10-15
CN1244796A (zh) 2000-02-16
CZ295502B6 (cs) 2005-08-17
KR20000052971A (ko) 2000-08-25
NO992114L (no) 1999-08-26
DE69815316D1 (de) 2003-07-10
HUP0002056A3 (en) 2001-01-29
SK54499A3 (en) 2000-01-18
ID21477A (id) 1999-06-17
CY2384B1 (en) 2004-06-04
DK0969821T3 (da) 2003-09-15
SK284813B6 (sk) 2005-12-01
BG64434B1 (en) 2005-02-28
NO325102B1 (no) 2008-02-04
CA2269501A1 (en) 1998-10-01
WO1998042318A1 (en) 1998-10-01
HUP0002056A2 (hu) 2000-12-28
CA2269501C (en) 2005-11-08
PT969821E (pt) 2003-10-31
IL129575A0 (en) 2000-02-29
ES2201485T3 (es) 2004-03-16
EP0969821A1 (en) 2000-01-12

Similar Documents

Publication Publication Date Title
EE03904B1 (et) Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid
EE9700031A (et) Pürido-liitunud tienüül- ja furanüüloksasolidinoonid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
EE9700145A (et) Tsükloalkaanpüridiinid, nende valmistamismeetod, kasutamine ravimite tootmiseks ja nimetatud ühendeid sisaldavad ravimid
EE200100431A (et) 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine
HUP0002744A3 (en) Rapidly releasing and taste-masking pharmaceutical dosage form
EE04417B1 (et) Peroraalne farmatseutiline pulseeriva vabanemisega annusvorm, selle valmistamise meetod ja kasutamine
DK0966454T3 (da) Disubstituerede bicykliske heterocykler, deres fremstilling og deres anvendelse som lægemidler
IS5245A (is) Lyfjablanda úr ómeprasól
NO985368D0 (no) Substituerte imidazolidinderivater, deres fremstilling, deres anvendelse og farmas°ytiske preparater inneholdende forbindelsene
BR0014465B1 (pt) 1,1'-bifenil-2-carbonamidas 2'-substituÍdas, preparado farmacÊutico e aplicaÇÕes dos referidos compostos.
EE200000037A (et) Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena
DE59910858D1 (de) Pharmazeutische zubereitung von moxifloxacin
EE04497B1 (et) Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine
NO20022021D0 (no) Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidler
EE200000226A (et) 3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon
EE9900162A (et) Rinnavähi vältimise meetod, farmatseutiline preparaat ja toode ning toimeaine kasutamine
EE03996B1 (et) Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
EE9800075A (et) Kombineeritud ravimpreparaat, selle kasutamine ja meetod selle valmistamiseks
DK0879054T3 (da) Anvendelse af pyrrolidionderivater til fremstilling af medikamenter til behandling af narkotikamisbrug
DE69907735D1 (de) Melatoninderivate und diese enthaltende pharmazeutische zubereitung
EE200000796A (et) Ravimkuulike, selle valmistamismeetod ja farmatseutiline doseerimisvorm, ravimkuulikeste kasutaminefarmatseutilise doseerimisvormi valmistamiseks ning farmatseutiline pakend
EE200000018A (et) 6-pürrolidiin-2-üülpüridiinid, nende valmistamine ja terapeutiline kasutamine
DE19681529D2 (de) Pharmazeutische Darreichungsform
FI972988A (fi) Menetelmiä ja farmaseuttisia koostumuksia, joissa käytetään desmetyyliselegiliiniä
EE200200229A (et) Diarüülenüünid, kompositsioon ja farmatseutiline kompositsioon

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231