NZ603339A - Modulation of transthyretin expression - Google Patents
Modulation of transthyretin expressionInfo
- Publication number
- NZ603339A NZ603339A NZ603339A NZ60333911A NZ603339A NZ 603339 A NZ603339 A NZ 603339A NZ 603339 A NZ603339 A NZ 603339A NZ 60333911 A NZ60333911 A NZ 60333911A NZ 603339 A NZ603339 A NZ 603339A
- Authority
- NZ
- New Zealand
- Prior art keywords
- wing segment
- linked nucleosides
- modulation
- segment
- transthyretin expression
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/52—Physical structure branched
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32953810P | 2010-04-29 | 2010-04-29 | |
| US40516310P | 2010-10-20 | 2010-10-20 | |
| PCT/US2011/034661 WO2011139917A1 (en) | 2010-04-29 | 2011-04-29 | Modulation of transthyretin expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ603339A true NZ603339A (en) | 2015-01-30 |
Family
ID=44903998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ603339A NZ603339A (en) | 2010-04-29 | 2011-04-29 | Modulation of transthyretin expression |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US20110294868A1 (enExample) |
| EP (1) | EP2563920B1 (enExample) |
| JP (1) | JP5896175B2 (enExample) |
| KR (2) | KR20180026798A (enExample) |
| CN (1) | CN103038345B (enExample) |
| BR (1) | BR112012027547B1 (enExample) |
| CA (2) | CA2994063A1 (enExample) |
| CY (2) | CY1119070T1 (enExample) |
| DK (1) | DK2563920T3 (enExample) |
| ES (1) | ES2625689T3 (enExample) |
| HR (1) | HRP20170737T1 (enExample) |
| HU (2) | HUE031909T2 (enExample) |
| IL (1) | IL222697A (enExample) |
| LT (2) | LT2563920T (enExample) |
| LU (1) | LUC00096I2 (enExample) |
| MX (1) | MX343559B (enExample) |
| NL (1) | NL300963I2 (enExample) |
| NO (1) | NO2019001I1 (enExample) |
| NZ (1) | NZ603339A (enExample) |
| PL (1) | PL2563920T3 (enExample) |
| PT (1) | PT2563920T (enExample) |
| RS (1) | RS56011B1 (enExample) |
| RU (1) | RU2592669C2 (enExample) |
| SI (1) | SI2563920T1 (enExample) |
| SM (1) | SMT201700209T1 (enExample) |
| WO (1) | WO2011139917A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
| AU2009307677C1 (en) | 2008-10-20 | 2022-09-22 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin |
| US9101643B2 (en) | 2009-11-03 | 2015-08-11 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of transthyretin (TTR) |
| HRP20170737T1 (hr) * | 2010-04-29 | 2017-07-28 | Ionis Pharmaceuticals, Inc. | Modulacija ekspresije transtiretina |
| JP6129844B2 (ja) | 2011-09-14 | 2017-05-17 | ラナ セラピューティクス インコーポレイテッド | 多量体オリゴヌクレオチド化合物 |
| MY167390A (en) | 2011-11-18 | 2018-08-16 | Alnylam Pharmaceuticals Inc | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| US9574193B2 (en) | 2012-05-17 | 2017-02-21 | Ionis Pharmaceuticals, Inc. | Methods and compositions for modulating apolipoprotein (a) expression |
| WO2013173789A2 (en) * | 2012-05-17 | 2013-11-21 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions |
| CA2884608C (en) | 2012-09-14 | 2025-05-20 | Translate Bio Ma, Inc. | MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS |
| SG10201804331TA (en) | 2012-11-15 | 2018-07-30 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
| US20150368642A1 (en) | 2013-01-30 | 2015-12-24 | Hoffmann-La Roche Inc. | Lna oligonucleotide carbohydrate conjugates |
| CA2921162A1 (en) * | 2013-05-01 | 2014-11-06 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US10280423B2 (en) | 2014-05-01 | 2019-05-07 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating complement factor B expression |
| US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EP4137138A1 (en) | 2014-08-29 | 2023-02-22 | Alnylam Pharmaceuticals, Inc. | Methods of treating transthyretin (ttr) mediated amyloidosis |
| WO2016040748A1 (en) | 2014-09-12 | 2016-03-17 | Ionis Pharmaceuticals, Inc. | Compositions and methods for detection of smn protein in a subject and treatment of a subject |
| WO2016130943A1 (en) | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Hybrid oligonucleotides and uses thereof |
| WO2016130963A1 (en) * | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Compositions and methods for modulating rna |
| US10851371B2 (en) | 2015-04-10 | 2020-12-01 | Ionis Pharmaceuticals, Inc. | Modulation of SMN expression |
| JP6896703B2 (ja) | 2015-07-31 | 2021-06-30 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | TTR関連疾患を治療または予防するためのトランスサイレチン(TTR)iRNA組成物およびその使用方法 |
| EP3387131A4 (en) * | 2015-12-09 | 2019-08-07 | Alnylam Pharmaceuticals, Inc. | AGAINST PROGRAMMED CELL DEOD 1 LIGAND 1 (PD-L1) POLYNUCLEOTIDE AGENT AND METHOD OF USE THEREOF |
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