MX343559B - Modulacion de la expresion de transtiretina. - Google Patents

Modulacion de la expresion de transtiretina.

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Publication number
MX343559B
MX343559B MX2012012624A MX2012012624A MX343559B MX 343559 B MX343559 B MX 343559B MX 2012012624 A MX2012012624 A MX 2012012624A MX 2012012624 A MX2012012624 A MX 2012012624A MX 343559 B MX343559 B MX 343559B
Authority
MX
Mexico
Prior art keywords
modulation
transthyretin
transthyretin expression
compositions
compounds
Prior art date
Application number
MX2012012624A
Other languages
English (en)
Spanish (es)
Other versions
MX2012012624A (es
Inventor
M Freier Susan
P Monia Brett
M Siwkowski Andrew
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of MX2012012624A publication Critical patent/MX2012012624A/es
Publication of MX343559B publication Critical patent/MX343559B/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/34—Spatial arrangement of the modifications
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MX2012012624A 2010-04-29 2011-04-29 Modulacion de la expresion de transtiretina. MX343559B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32953810P 2010-04-29 2010-04-29
US40516310P 2010-10-20 2010-10-20
PCT/US2011/034661 WO2011139917A1 (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

Publications (2)

Publication Number Publication Date
MX2012012624A MX2012012624A (es) 2013-05-06
MX343559B true MX343559B (es) 2016-11-10

Family

ID=44903998

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012012624A MX343559B (es) 2010-04-29 2011-04-29 Modulacion de la expresion de transtiretina.

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EP (1) EP2563920B1 (enExample)
JP (1) JP5896175B2 (enExample)
KR (2) KR20180026798A (enExample)
CN (1) CN103038345B (enExample)
BR (1) BR112012027547B1 (enExample)
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ES (1) ES2625689T3 (enExample)
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IL (1) IL222697A (enExample)
LT (2) LT2563920T (enExample)
LU (1) LUC00096I2 (enExample)
MX (1) MX343559B (enExample)
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EP2937418B1 (en) 2008-10-20 2017-10-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of transthyretin
JP5723378B2 (ja) 2009-11-03 2015-05-27 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トランスサイレチン（ｔｔｒ）を阻害する脂質製剤化組成物及び方法
ES2625689T3 (es) * 2010-04-29 2017-07-20 Ionis Pharmaceuticals, Inc. Modulación de la expresión de transtiretina
HK1200484A1 (zh) 2011-09-14 2015-08-07 Translate Bio Ma, Inc. 多聚寡核苷酸化合物
UA118649C2 (uk) 2011-11-18 2019-02-25 Елнілем Фармасьютікалз, Інк. ДВОЛАНЦЮГОВИЙ ЗАСІБ ДЛЯ PHKі ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ЕКСПРЕСІЇ ТРАНСТИРЕТИНУ (TTR)
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CN104583402A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节mecp2表达的组合物和方法
US20160002624A1 (en) 2012-05-17 2016-01-07 Isis Pharmaceuticals, Inc. Antisense oligonucleotide compositions
US9574193B2 (en) 2012-05-17 2017-02-21 Ionis Pharmaceuticals, Inc. Methods and compositions for modulating apolipoprotein (a) expression
US20150247141A1 (en) 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
CA2889044A1 (en) 2012-11-15 2014-05-22 Roche Innovation Center Copenhagen A/S Anti apob antisense conjugate compounds
CA2893801A1 (en) 2013-01-30 2014-08-07 F. Hoffmann-La Roche Ag Lna oligonucleotide carbohydrate conjugates
PL2992098T3 (pl) 2013-05-01 2019-09-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji hbv i ttr
CR20160554A (es) 2014-05-01 2017-03-07 Ionis Pharmaceuticals Inc Composiciones y métodos para modular la expresión del factor b del complemento
US10570169B2 (en) 2014-05-22 2020-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
KR102410072B1 (ko) * 2014-08-29 2022-06-20 알닐람 파마슈티칼스 인코포레이티드 트랜스타이레틴(ttr) 매개 아밀로이드증의 치료 방법
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