CA2797792C - Modulation of transthyretin expression - Google Patents

Modulation of transthyretin expression Download PDF

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Publication number
CA2797792C
CA2797792C CA2797792A CA2797792A CA2797792C CA 2797792 C CA2797792 C CA 2797792C CA 2797792 A CA2797792 A CA 2797792A CA 2797792 A CA2797792 A CA 2797792A CA 2797792 C CA2797792 C CA 2797792C
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Prior art keywords
certain embodiments
compound
seq
transthyretin
modified oligonucleotide
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Expired - Fee Related
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CA2797792A
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English (en)
French (fr)
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CA2797792A1 (en
Inventor
Brett P. Monia
Susan M. Freier
Andrew M. Siwkowski
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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Priority to CA2994063A priority Critical patent/CA2994063A1/en
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Publication of CA2797792C publication Critical patent/CA2797792C/en
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CA2797792A 2010-04-29 2011-04-29 Modulation of transthyretin expression Expired - Fee Related CA2797792C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2994063A CA2994063A1 (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32953810P 2010-04-29 2010-04-29
US61/329,538 2010-04-29
US40516310P 2010-10-20 2010-10-20
US61/405,163 2010-10-20
PCT/US2011/034661 WO2011139917A1 (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

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CA2994063A Division CA2994063A1 (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

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CA2797792A1 CA2797792A1 (en) 2011-11-10
CA2797792C true CA2797792C (en) 2018-02-27

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CA2797792A Expired - Fee Related CA2797792C (en) 2010-04-29 2011-04-29 Modulation of transthyretin expression

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EP (1) EP2563920B1 (enExample)
JP (1) JP5896175B2 (enExample)
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EP2496238A4 (en) 2009-11-03 2013-10-02 Alnylam Pharmaceuticals Inc FORMULATED LIPID COMPOSITIONS AND METHODS FOR INHIBITING TRANSTHYRETIN EXPRESSION (TTR)
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