NZ580828A - Antibodies against clostridium difficile toxin B and uses thereof - Google Patents
Antibodies against clostridium difficile toxin B and uses thereofInfo
- Publication number
- NZ580828A NZ580828A NZ580828A NZ58082805A NZ580828A NZ 580828 A NZ580828 A NZ 580828A NZ 580828 A NZ580828 A NZ 580828A NZ 58082805 A NZ58082805 A NZ 58082805A NZ 580828 A NZ580828 A NZ 580828A
- Authority
- NZ
- New Zealand
- Prior art keywords
- seq
- chain variable
- antibody
- variable region
- toxin
- Prior art date
Links
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S424/00—Drug, bio-affecting and body treating compositions
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Landscapes
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| NZ548821A NZ548821A (en) | 2004-02-06 | 2005-02-04 | Antibodies against clostridium difficile toxins and uses thereof |
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| NZ548821A NZ548821A (en) | 2004-02-06 | 2005-02-04 | Antibodies against clostridium difficile toxins and uses thereof |
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| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| ES2643760T3 (es) * | 2004-02-06 | 2017-11-24 | University Of Massachusetts | Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos |
| CN101068560B (zh) * | 2004-06-28 | 2011-03-09 | 独立行政法人科学技术振兴机构 | 毒素中和性肽的筛选方法和STX2抑制性肽以及Vero毒素中和剂 |
| EP1833510A4 (en) * | 2004-12-27 | 2010-02-10 | Progenics Pharmaceuticals Neva | ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME |
| EP2054044B1 (de) | 2006-08-02 | 2014-07-23 | Johannes Gutenberg-Universität Mainz | Arzneimittel gegen lct-vergiftungen |
| AU2014201846B2 (en) * | 2007-01-30 | 2016-07-07 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| EP2450372B1 (en) | 2007-01-30 | 2015-04-22 | Epivax, Inc. | Regulatory T cell epitopes, compositions and uses thereof |
| US20080188007A1 (en) * | 2007-02-06 | 2008-08-07 | Meridian Life Science, Inc. | Fluorescent single chain antibody and its use in detection of analytes |
| CN101363867B (zh) * | 2008-05-26 | 2012-12-19 | 北京庄笛浩禾生物医学科技有限公司 | 一种艰难梭菌a、b毒素胶体金检测试纸条及其制备方法 |
| JP2011524741A (ja) * | 2008-05-27 | 2011-09-08 | 協和発酵キリン株式会社 | インターロイキン１０受容体（ｉｌ−１０ｒ）抗体及び使用方法 |
| DE102008029688B4 (de) * | 2008-06-24 | 2016-06-23 | Biodics Gmbh | Verfahren zum Nachweis und zur Identifikation eines varianten C. difficile Stammes in einer Probe |
| CN102365097A (zh) * | 2009-02-20 | 2012-02-29 | 卫生防护机构 | 艰难梭菌毒素的抗体 |
| US8889363B2 (en) | 2009-07-27 | 2014-11-18 | Biodics | Method for the detection and identification of a variant C. difficile strain in a sample |
| JP5591332B2 (ja) * | 2009-07-27 | 2014-09-17 | バイオディクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 試料中における変異したｃ．ディフィシル菌株を検出および同定するための方法 |
| WO2011063346A1 (en) * | 2009-11-20 | 2011-05-26 | Northshore University Health System Research Institute | Targeting of the c-terminal segment of c. difficile toxin b for improved clinical diagnosis, prevention, and treatment |
| GB0921288D0 (en) * | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| WO2011130650A2 (en) | 2010-04-15 | 2011-10-20 | Progenics Pharmaceuticals, Inc. | Antibodies for the treatment of clostridium difficile-associated infection and disease |
| RU2630663C9 (ru) * | 2010-04-15 | 2017-11-29 | Проджиникс Фармасьютикалс, Инк. | Антитела для лечения ассоциированных с clostridium difficile инфекции и заболеваний |
| ES2867375T3 (es) | 2010-09-03 | 2021-10-20 | Valneva Austria Gmbh | Polipéptido aislado de las proteínas de la toxina A y la toxina B de C. difficile y sus usos |
| GB201016742D0 (en) * | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| WO2012055030A1 (en) * | 2010-10-25 | 2012-05-03 | National Research Council Of Canada | Clostridium difficile-specific antibodies and uses thereof |
| US20140127215A1 (en) * | 2010-12-29 | 2014-05-08 | Cangene Corporation | Clostridium difficile antigens |
| WO2012118693A1 (en) | 2011-02-28 | 2012-09-07 | Northshore University Healthsystem | Methods of diagnosing clostridium difficile infection |
| BR112013027229B1 (pt) | 2011-04-22 | 2020-10-27 | Wyeth Llc | polipeptídeo imunogênico isolado e seu uso, composição imunogênica e seu uso, célula recombinante ou progênie da mesma, e método de produção de uma toxina de clostridium difficile mutante |
| KR101955365B1 (ko) | 2011-07-12 | 2019-03-07 | 필라델피아 헬스 앤드 에듀케이션 코포레이션 디/비/에이 드렉셀 유니버시티 컬리지 오브 메디슨 | 신규한 클로스트리듐 디피실(Clostridium Difficile) DNA 백신 |
| AU2012298877B2 (en) | 2011-08-22 | 2018-01-04 | Emergent Biosolutions Canada Inc. | Clostridium difficile antibodies |
| PH12014500456A1 (en) * | 2011-09-16 | 2014-04-14 | Ucb Pharma Sa | Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile |
| WO2013071409A1 (en) | 2011-11-18 | 2013-05-23 | National Research Council Of Canada (Nrc) | Clostridium difficile lipoteichoic acid and uses thereof |
| JP6084631B2 (ja) | 2011-12-08 | 2017-02-22 | ノバルティス アーゲー | Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素ベースのワクチン |
| DE102011121238A1 (de) * | 2011-12-14 | 2013-06-20 | Universitätsklinikum Hamburg-Eppendorf | Einzeldomänen-antikörper gegen clostridium difficile toxine |
| AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| SG10201610123UA (en) * | 2012-03-02 | 2017-01-27 | Regeneron Pharma | Human antibodies to clostridium difficile toxins |
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