NZ324337A - Taxoids, preparation thereof and pharmaceutical compositions containing same - Google Patents

Taxoids, preparation thereof and pharmaceutical compositions containing same

Info

Publication number
NZ324337A
NZ324337A NZ324337A NZ32433796A NZ324337A NZ 324337 A NZ324337 A NZ 324337A NZ 324337 A NZ324337 A NZ 324337A NZ 32433796 A NZ32433796 A NZ 32433796A NZ 324337 A NZ324337 A NZ 324337A
Authority
NZ
New Zealand
Prior art keywords
radical
hydrogen atom
together form
formula
optionally substituted
Prior art date
Application number
NZ324337A
Other languages
English (en)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NZ324337A publication Critical patent/NZ324337A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ324337A 1995-12-22 1996-12-19 Taxoids, preparation thereof and pharmaceutical compositions containing same NZ324337A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
NZ324337A true NZ324337A (en) 2000-03-27

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ324337A NZ324337A (en) 1995-12-22 1996-12-19 Taxoids, preparation thereof and pharmaceutical compositions containing same

Country Status (40)

Country Link
US (1) US5728849A (oth)
EP (1) EP0876362B1 (oth)
JP (1) JP3953106B2 (oth)
KR (1) KR100500351B1 (oth)
CN (1) CN1103766C (oth)
AR (1) AR005197A1 (oth)
AT (1) ATE250593T1 (oth)
AU (1) AU712597B2 (oth)
BG (1) BG63204B1 (oth)
BR (1) BR9612135A (oth)
CA (1) CA2238884C (oth)
CO (1) CO4520184A1 (oth)
CZ (1) CZ294972B6 (oth)
DE (1) DE69630145T2 (oth)
DK (1) DK0876362T3 (oth)
DZ (1) DZ2149A1 (oth)
EA (1) EA001533B1 (oth)
ES (1) ES2202490T3 (oth)
FR (1) FR2742751B1 (oth)
HU (1) HU225032B1 (oth)
IL (1) IL124994A (oth)
IN (4) IN186768B (oth)
MA (1) MA26412A1 (oth)
MX (1) MX9804688A (oth)
MY (1) MY113934A (oth)
NO (1) NO317358B1 (oth)
NZ (1) NZ324337A (oth)
OA (1) OA10700A (oth)
PE (1) PE25198A1 (oth)
PL (1) PL189311B1 (oth)
PT (1) PT876362E (oth)
RO (1) RO116194B1 (oth)
SK (1) SK282835B6 (oth)
TN (1) TNSN96169A1 (oth)
TR (1) TR199801179T2 (oth)
TW (1) TW371659B (oth)
UA (1) UA48205C2 (oth)
UY (1) UY24386A1 (oth)
WO (1) WO1997023473A1 (oth)
ZA (1) ZA9610737B (oth)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
WO2001057031A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
EE05735B1 (et) * 2001-02-24 2015-01-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
MX2008014024A (es) 2006-05-04 2008-11-14 Boehringer Ingelheim Int Formas poliformas.
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
EP3542801A1 (en) * 2007-08-17 2019-09-25 Boehringer Ingelheim International GmbH Purin derivatives for use in the treatment of fap-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
KR101657960B1 (ko) * 2008-08-15 2016-09-20 베링거 인겔하임 인터내셔날 게엠베하 Ｆａｂ-관련 질환의 치료에 사용하기 위한 푸린 유도체
JP2012502081A (ja) 2008-09-10 2012-01-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連症状の治療のための組み合わせ治療
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh) 2008-12-23 2011-11-23 贝林格尔.英格海姆国际有限公司 有机化合物的盐形式
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
CN107115530A (zh) 2009-11-27 2017-09-01 勃林格殷格翰国际有限公司 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗
CA2797310C (en) 2010-05-05 2020-03-31 Boehringer Ingelheim International Gmbh Glp-1 receptor agonist and dpp-4 inhibitor combination therapy
EP3124041A1 (en) 2010-06-24 2017-02-01 Boehringer Ingelheim International GmbH Diabetes therapy
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
HUE061596T2 (hu) 2011-07-15 2023-07-28 Boehringer Ingelheim Int Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
EP4151218A1 (en) 2012-05-14 2023-03-22 Boehringer Ingelheim International GmbH Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
FI3122757T3 (fi) 2014-02-28 2023-10-10 Hangzhou Dac Biotech Co Ltd Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
EP4678240A2 (en) 2015-07-12 2026-01-14 Hangzhou Dac Biotech Co., Ltd. Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10155000B2 (en) 2016-06-10 2018-12-18 Boehringer Ingelheim International Gmbh Medical use of pharmaceutical combination or composition
MX2019005583A (es) 2016-11-14 2019-10-21 Hangzhou Dac Biotech Co Ltd Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.
KR20240095442A (ko) 2021-11-03 2024-06-25 항저우 디에이씨 바이오테크 씨오, 엘티디 항체의 특이적 접합

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
AU672006B2 (en) * 1992-04-17 1996-09-19 Abbott Laboratories Taxol derivatives
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
DE69630145T2 (de) 2004-07-15
FR2742751A1 (fr) 1997-06-27
CA2238884A1 (fr) 1997-07-03
MY113934A (en) 2002-06-29
DK0876362T3 (da) 2004-02-02
PL189311B1 (pl) 2005-07-29
TW371659B (en) 1999-10-11
HK1017895A1 (en) 1999-12-03
UY24386A1 (es) 2001-08-27
HUP9904046A3 (en) 2001-08-28
UA48205C2 (uk) 2002-08-15
JP3953106B2 (ja) 2007-08-08
DE69630145D1 (de) 2003-10-30
ES2202490T3 (es) 2004-04-01
IN186768B (oth) 2001-11-03
NO317358B1 (no) 2004-10-18
PL327405A1 (en) 1998-12-07
CN1103766C (zh) 2003-03-26
FR2742751B1 (fr) 1998-01-30
AU1180997A (en) 1997-07-17
ZA9610737B (en) 1997-06-27
TNSN96169A1 (fr) 2005-03-15
TR199801179T2 (xx) 1998-10-21
JP2000502671A (ja) 2000-03-07
PT876362E (pt) 2004-02-27
EP0876362A1 (fr) 1998-11-11
IN188680B (oth) 2002-10-26
HU225032B1 (en) 2006-05-29
EA001533B1 (ru) 2001-04-23
AR005197A1 (es) 1999-04-14
NO982580L (no) 1998-06-05
ATE250593T1 (de) 2003-10-15
AU712597B2 (en) 1999-11-11
US5728849A (en) 1998-03-17
EA199800588A1 (ru) 1998-12-24
SK282835B6 (sk) 2002-12-03
BG63204B1 (bg) 2001-06-29
IL124994A (en) 2000-12-06
DZ2149A1 (fr) 2002-10-23
CZ294972B6 (cs) 2005-04-13
KR19990076680A (ko) 1999-10-15
BG102569A (en) 1999-04-30
CA2238884C (fr) 2007-02-06
CZ196198A3 (cs) 1998-09-16
OA10700A (fr) 2002-11-27
CN1205697A (zh) 1999-01-20
HUP9904046A1 (hu) 2001-04-28
SK85398A3 (en) 1998-11-04
IN188470B (oth) 2002-09-28
IN188469B (oth) 2002-09-28
EP0876362B1 (fr) 2003-09-24
IL124994A0 (en) 1999-01-26
MA26412A1 (fr) 2004-12-20
BR9612135A (pt) 1999-07-13
RO116194B1 (ro) 2000-11-30
NO982580D0 (no) 1998-06-05
CO4520184A1 (es) 1997-10-15
WO1997023473A1 (fr) 1997-07-03
PE25198A1 (es) 1998-05-10
MX9804688A (es) 1998-10-31
KR100500351B1 (ko) 2005-12-21

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