NZ266525A - 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine derivatives and medicaments - Google Patents

4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine derivatives and medicaments

Info

Publication number
NZ266525A
NZ266525A NZ266525A NZ26652594A NZ266525A NZ 266525 A NZ266525 A NZ 266525A NZ 266525 A NZ266525 A NZ 266525A NZ 26652594 A NZ26652594 A NZ 26652594A NZ 266525 A NZ266525 A NZ 266525A
Authority
NZ
New Zealand
Prior art keywords
ethyl
oxo
tetrahydro
pyridine
pyrazolo
Prior art date
Application number
NZ266525A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NZ266525A publication Critical patent/NZ266525A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NZ266525A 1993-07-06 1994-06-16 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine derivatives and medicaments NZ266525A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06
PCT/IB1994/000156 WO1995001980A1 (en) 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines

Publications (1)

Publication Number Publication Date
NZ266525A true NZ266525A (en) 1997-10-24

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ266525A NZ266525A (en) 1993-07-06 1994-06-16 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine derivatives and medicaments

Country Status (20)

Country Link
EP (1) EP0707585A1 (enrdf_load_html_response)
JP (1) JP2944048B2 (enrdf_load_html_response)
KR (1) KR100228949B1 (enrdf_load_html_response)
CN (1) CN1048015C (enrdf_load_html_response)
AU (1) AU695301B2 (enrdf_load_html_response)
BR (1) BR9406946A (enrdf_load_html_response)
CA (1) CA2166721C (enrdf_load_html_response)
CZ (1) CZ3696A3 (enrdf_load_html_response)
EG (1) EG20513A (enrdf_load_html_response)
FI (1) FI943208L (enrdf_load_html_response)
HU (1) HUT74170A (enrdf_load_html_response)
IL (1) IL110175A (enrdf_load_html_response)
MX (1) MX9405132A (enrdf_load_html_response)
NO (1) NO305029B1 (enrdf_load_html_response)
NZ (1) NZ266525A (enrdf_load_html_response)
PL (1) PL312426A1 (enrdf_load_html_response)
RU (1) RU2131876C1 (enrdf_load_html_response)
TW (1) TW316904B (enrdf_load_html_response)
WO (1) WO1995001980A1 (enrdf_load_html_response)
ZA (1) ZA944844B (enrdf_load_html_response)

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CZ120097A3 (cs) * 1994-10-20 1998-01-14 Pfizer Inc. Bicyklické tetrahydropyrazolopyridiny a farmaceutické prostředky na jejich bázi
SK282167B6 (sk) * 1995-06-06 2001-11-06 Pfizer Inc. Tricyklické 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a] pyridíny a farmaceutický prostriedok na ich báze
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
HUP9903248A3 (en) * 1996-09-04 2000-07-28 Pfizer Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
CA2305370C (en) * 1997-09-26 2006-11-28 Gerald Mcmahon Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
MXPA01006502A (es) 1998-12-23 2002-04-08 Du Pont Pharm Co Heterobiciclos que contienen nitrogenos como inhibidores del factor xa.
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
CZ302882B6 (cs) 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
EE05405B1 (et) * 2000-08-10 2011-04-15 Pharmacia Italia S.P.A. Kinaasi inhibiitoritena toimivad bitskloprasoolid, nende valmistamismeetod, kasutamine ja neid sisaldavad farmatseutilised kompositsioonid
ES2261463T3 (es) * 2000-08-14 2006-11-16 Ortho-Mcneil Pharmaceutical, Inc. Pirazoles sustituidos.
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
US6706730B2 (en) 2001-04-18 2004-03-16 Bristol-Myers Squibb Pharma Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
US6750225B2 (en) 2001-04-18 2004-06-15 Bristol-Myers Squibb Pharms Company 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
EP1396493A4 (en) * 2001-04-26 2005-08-03 Ajinomoto Kk HETEROCYCLIC COMPOUNDS
ME00090B (me) * 2001-09-21 2010-10-10 Bristol Myers Squibb Holdings Ireland Jedinjenja koja sadrže laktam i njihovi derivati kao inhibitori faktora xa
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
PE20050521A1 (es) 2003-02-27 2005-09-11 Uriach Y Compania S A J Derivados de pirazolopiridina
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3365459A (en) 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
CN1129940A (zh) 1996-08-28
AU6805794A (en) 1995-02-06
TW316904B (enrdf_load_html_response) 1997-10-01
NO305029B1 (no) 1999-03-22
HU9503934D0 (en) 1996-03-28
HUT74170A (en) 1996-11-28
CA2166721A1 (en) 1995-01-19
JPH08507084A (ja) 1996-07-30
RU2131876C1 (ru) 1999-06-20
PL312426A1 (en) 1996-04-29
EG20513A (en) 1999-06-30
ZA944844B (en) 1996-01-05
JP2944048B2 (ja) 1999-08-30
FI943208A7 (fi) 1995-01-07
AU695301B2 (en) 1998-08-13
BR9406946A (pt) 1996-08-06
CN1048015C (zh) 2000-01-05
FI943208L (fi) 1995-01-07
IL110175A0 (en) 1994-10-07
CA2166721C (en) 1999-07-27
NO960056D0 (no) 1996-01-05
FI943208A0 (fi) 1994-07-05
NO960056L (no) 1996-01-05
IL110175A (en) 2000-01-31
MX9405132A (es) 1995-01-31
WO1995001980A1 (en) 1995-01-19
KR100228949B1 (ko) 1999-11-01
KR960703852A (ko) 1996-08-31
CZ3696A3 (en) 1997-06-11
EP0707585A1 (en) 1996-04-24

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