NZ243443A - Triazolopyrimidine derivatives, preparation and pharmaceutical compositions thereof - Google Patents
Triazolopyrimidine derivatives, preparation and pharmaceutical compositions thereofInfo
- Publication number
- NZ243443A NZ243443A NZ243443A NZ24344392A NZ243443A NZ 243443 A NZ243443 A NZ 243443A NZ 243443 A NZ243443 A NZ 243443A NZ 24344392 A NZ24344392 A NZ 24344392A NZ 243443 A NZ243443 A NZ 243443A
- Authority
- NZ
- New Zealand
- Prior art keywords
- preparation
- pharmaceutical compositions
- triazolopyrimidine derivatives
- derivatives
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9108486A FR2678618B1 (fr) | 1991-07-05 | 1991-07-05 | Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ243443A true NZ243443A (en) | 1995-01-27 |
Family
ID=9414783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ243443A NZ243443A (en) | 1991-07-05 | 1992-07-03 | Triazolopyrimidine derivatives, preparation and pharmaceutical compositions thereof |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5217973A (enExample) |
| EP (1) | EP0521768B1 (enExample) |
| JP (1) | JP3140566B2 (enExample) |
| KR (1) | KR100243628B1 (enExample) |
| AT (1) | ATE101153T1 (enExample) |
| AU (1) | AU655288B2 (enExample) |
| CA (1) | CA2072233C (enExample) |
| CZ (1) | CZ284757B6 (enExample) |
| DE (1) | DE69200045T2 (enExample) |
| DK (1) | DK0521768T3 (enExample) |
| EE (1) | EE03003B1 (enExample) |
| ES (1) | ES2063570T3 (enExample) |
| FR (1) | FR2678618B1 (enExample) |
| HU (2) | HU220225B (enExample) |
| IE (1) | IE65635B1 (enExample) |
| IL (1) | IL102367A (enExample) |
| LV (1) | LV10717B (enExample) |
| MD (1) | MD523G2 (enExample) |
| NZ (1) | NZ243443A (enExample) |
| RU (1) | RU2103270C1 (enExample) |
| SK (1) | SK279902B6 (enExample) |
| TW (1) | TW221445B (enExample) |
| ZA (1) | ZA924954B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5358950A (en) * | 1991-07-05 | 1994-10-25 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists |
| US5387747A (en) * | 1992-02-24 | 1995-02-07 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present |
| FR2687677B1 (fr) * | 1992-02-24 | 1996-10-11 | Union Pharma Scient Appl | Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5389632A (en) * | 1992-02-24 | 1995-02-14 | Laboratoires Upsa | Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists |
| IT1263804B (it) * | 1993-01-22 | 1996-09-03 | Luso Farmaco Inst | Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista |
| US5358947A (en) * | 1993-09-13 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones |
| WO1998042711A1 (en) * | 1997-03-24 | 1998-10-01 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| WO2009158309A2 (en) * | 2008-06-25 | 2009-12-30 | Ligand Pharmaceuticals Inc. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| JP2024540921A (ja) * | 2021-10-19 | 2024-11-06 | 上海瑛派▲薬▼▲業▼有限公司 | Ｕｓｐ１阻害剤としての置換トリアゾロヘテロアリール化合物及びその応用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US269980A (en) * | 1883-01-02 | Horse power | ||
| GB859287A (en) * | 1958-10-03 | 1961-01-18 | Ici Ltd | Triazolopyrimidine derivatives and their preparation |
| GB897870A (en) * | 1959-06-15 | 1962-05-30 | Ici Ltd | s-triazolo[2, 3-c]pyrimidine derivatives |
| GB951652A (en) * | 1960-06-28 | 1964-03-11 | Wallace Broadbent | Sulphamyl triazolopyrimidines and their preparation |
| US4269980A (en) * | 1979-12-17 | 1981-05-26 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines |
| US4572910A (en) * | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| US4528288A (en) * | 1983-05-02 | 1985-07-09 | Riker Laboratories, Inc. | Substituted triazolo[1,5-c]pyrimidines |
| US4532242A (en) * | 1983-05-02 | 1985-07-30 | Riker Laboratories, Inc. | Substituted triazolo[4,3-c]pyrimidines |
| US4562192A (en) * | 1984-02-03 | 1985-12-31 | G. D. Searle & Co. | 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazole[1,5-c]pyrimidines, and pharmaceutical compositions containing them |
| US4728652A (en) * | 1985-05-20 | 1988-03-01 | E. R. Squibb & Sons, Inc. | 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure |
| US5010195A (en) * | 1988-05-25 | 1991-04-23 | The Dow Chemical Company | Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides |
| US5073566A (en) * | 1989-11-30 | 1991-12-17 | Eli Lilly And Company | Angiotensin ii antagonist 1,3-imidazoles and use thereas |
| EP0435827A3 (en) * | 1989-12-28 | 1991-11-13 | Ciba-Geigy Ag | Diaza compounds |
| WO1991015209A1 (en) * | 1990-03-30 | 1991-10-17 | Merck & Co., Inc. | Substituted pyrimidines, pyrimidinones and pyridopyrimidines |
| US5177206A (en) * | 1991-10-08 | 1993-01-05 | Dowelanco | Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides |
-
1991
- 1991-07-05 FR FR9108486A patent/FR2678618B1/fr not_active Expired - Lifetime
- 1991-08-07 US US07/741,134 patent/US5217973A/en not_active Expired - Lifetime
-
1992
- 1992-06-24 CA CA002072233A patent/CA2072233C/en not_active Expired - Lifetime
- 1992-06-30 IL IL102367A patent/IL102367A/xx not_active IP Right Cessation
- 1992-06-30 ES ES92401850T patent/ES2063570T3/es not_active Expired - Lifetime
- 1992-06-30 DK DK92401850.0T patent/DK0521768T3/da active
- 1992-06-30 AT AT92401850T patent/ATE101153T1/de active
- 1992-06-30 EP EP92401850A patent/EP0521768B1/fr not_active Expired - Lifetime
- 1992-06-30 DE DE69200045T patent/DE69200045T2/de not_active Expired - Lifetime
- 1992-07-01 IE IE922015A patent/IE65635B1/en not_active IP Right Cessation
- 1992-07-02 SK SK2078-92A patent/SK279902B6/sk not_active IP Right Cessation
- 1992-07-02 AU AU19396/92A patent/AU655288B2/en not_active Expired
- 1992-07-02 CZ CS922078A patent/CZ284757B6/cs not_active IP Right Cessation
- 1992-07-03 ZA ZA924954A patent/ZA924954B/xx unknown
- 1992-07-03 HU HU9202227A patent/HU220225B/hu unknown
- 1992-07-03 RU SU5052543A patent/RU2103270C1/ru active
- 1992-07-03 NZ NZ243443A patent/NZ243443A/xx not_active IP Right Cessation
- 1992-07-04 TW TW081105325A patent/TW221445B/zh not_active IP Right Cessation
- 1992-07-04 KR KR1019920011916A patent/KR100243628B1/ko not_active Expired - Lifetime
- 1992-07-06 JP JP04200200A patent/JP3140566B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-29 LV LVP-94-60A patent/LV10717B/en unknown
- 1994-11-22 EE EE9400308A patent/EE03003B1/xx unknown
- 1994-12-30 MD MD95-0084A patent/MD523G2/ro active IP Right Grant
-
1995
- 1995-06-27 HU HU95P/P00446P patent/HU211473A9/hu unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |