DK0521768T3 - Nye triazolopyrimidin-derivater som er angiotensin II-receptor-antagonister, fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf - Google Patents

Nye triazolopyrimidin-derivater som er angiotensin II-receptor-antagonister, fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf

Info

Publication number
DK0521768T3
DK0521768T3 DK92401850.0T DK92401850T DK0521768T3 DK 0521768 T3 DK0521768 T3 DK 0521768T3 DK 92401850 T DK92401850 T DK 92401850T DK 0521768 T3 DK0521768 T3 DK 0521768T3
Authority
DK
Denmark
Prior art keywords
angiotensin
preparation
methods
receptor antagonists
pharmaceutical preparations
Prior art date
Application number
DK92401850.0T
Other languages
English (en)
Inventor
Jean-Marie Teulon
Nicole Bru-Magniez
Eric Nicolai
Original Assignee
Union Pharma Scient Appl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Pharma Scient Appl filed Critical Union Pharma Scient Appl
Application granted granted Critical
Publication of DK0521768T3 publication Critical patent/DK0521768T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK92401850.0T 1991-07-05 1992-06-30 Nye triazolopyrimidin-derivater som er angiotensin II-receptor-antagonister, fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf DK0521768T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108486A FR2678618B1 (fr) 1991-07-05 1991-07-05 Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.

Publications (1)

Publication Number Publication Date
DK0521768T3 true DK0521768T3 (da) 1994-08-15

Family

ID=9414783

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92401850.0T DK0521768T3 (da) 1991-07-05 1992-06-30 Nye triazolopyrimidin-derivater som er angiotensin II-receptor-antagonister, fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf

Country Status (23)

Country Link
US (1) US5217973A (da)
EP (1) EP0521768B1 (da)
JP (1) JP3140566B2 (da)
KR (1) KR100243628B1 (da)
AT (1) ATE101153T1 (da)
AU (1) AU655288B2 (da)
CA (1) CA2072233C (da)
CZ (1) CZ284757B6 (da)
DE (1) DE69200045T2 (da)
DK (1) DK0521768T3 (da)
EE (1) EE03003B1 (da)
ES (1) ES2063570T3 (da)
FR (1) FR2678618B1 (da)
HU (2) HU220225B (da)
IE (1) IE65635B1 (da)
IL (1) IL102367A (da)
LV (1) LV10717B (da)
MD (1) MD523G2 (da)
NZ (1) NZ243443A (da)
RU (1) RU2103270C1 (da)
SK (1) SK279902B6 (da)
TW (1) TW221445B (da)
ZA (1) ZA924954B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358950A (en) * 1991-07-05 1994-10-25 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
FR2687677B1 (fr) * 1992-02-24 1996-10-11 Union Pharma Scient Appl Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1263804B (it) * 1993-01-22 1996-09-03 Luso Farmaco Inst Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
US5358947A (en) * 1993-09-13 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones
DE69820866T2 (de) 1997-03-24 2004-12-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0719803D0 (en) * 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
WO2009158309A2 (en) * 2008-06-25 2009-12-30 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
AU2022368823A1 (en) * 2021-10-19 2024-05-16 Impact Therapeutics (Shanghai), Inc. Substituted triazoloheteroaryl compounds as usp1 inhibitors and the use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US269980A (en) * 1883-01-02 Horse power
GB859287A (en) * 1958-10-03 1961-01-18 Ici Ltd Triazolopyrimidine derivatives and their preparation
GB897870A (en) * 1959-06-15 1962-05-30 Ici Ltd s-triazolo[2, 3-c]pyrimidine derivatives
GB951652A (en) * 1960-06-28 1964-03-11 Wallace Broadbent Sulphamyl triazolopyrimidines and their preparation
US4269980A (en) * 1979-12-17 1981-05-26 American Cyanamid Company (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines
US4572910A (en) * 1983-03-03 1986-02-25 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4532242A (en) * 1983-05-02 1985-07-30 Riker Laboratories, Inc. Substituted triazolo[4,3-c]pyrimidines
US4528288A (en) * 1983-05-02 1985-07-09 Riker Laboratories, Inc. Substituted triazolo[1,5-c]pyrimidines
US4562192A (en) * 1984-02-03 1985-12-31 G. D. Searle & Co. 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazole[1,5-c]pyrimidines, and pharmaceutical compositions containing them
US4728652A (en) * 1985-05-20 1988-03-01 E. R. Squibb & Sons, Inc. 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure
US5010195A (en) * 1988-05-25 1991-04-23 The Dow Chemical Company Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
EP0435827A3 (en) * 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
EP0522038A4 (en) * 1990-03-30 1993-05-26 Merck & Co. Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
US5177206A (en) * 1991-10-08 1993-01-05 Dowelanco Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides

Also Published As

Publication number Publication date
SK207892A3 (en) 1995-08-09
LV10717A (lv) 1995-06-20
FR2678618B1 (fr) 1993-11-05
CA2072233C (en) 2003-11-18
CZ207892A3 (en) 1993-01-13
HU9202227D0 (en) 1992-10-28
LV10717B (en) 1995-12-20
AU655288B2 (en) 1994-12-15
IL102367A0 (en) 1993-01-14
SK279902B6 (sk) 1999-05-07
ES2063570T3 (es) 1995-01-01
KR100243628B1 (ko) 2000-03-02
IL102367A (en) 1997-06-10
ZA924954B (en) 1993-04-28
HU211473A9 (en) 1995-11-28
NZ243443A (en) 1995-01-27
HU220225B (hu) 2001-11-28
CA2072233A1 (en) 1993-01-06
HUT63422A (en) 1993-08-30
AU1939692A (en) 1993-01-07
MD523F1 (en) 1996-04-30
RU2103270C1 (ru) 1998-01-27
EP0521768B1 (fr) 1994-02-02
CZ284757B6 (cs) 1999-02-17
ATE101153T1 (de) 1994-02-15
JP3140566B2 (ja) 2001-03-05
DE69200045T2 (de) 1994-05-19
KR930002349A (ko) 1993-02-23
FR2678618A1 (fr) 1993-01-08
EE03003B1 (et) 1997-06-16
DE69200045D1 (de) 1994-03-17
IE922015A1 (en) 1993-01-13
TW221445B (da) 1994-03-01
EP0521768A1 (fr) 1993-01-07
US5217973A (en) 1993-06-08
JPH06122685A (ja) 1994-05-06
IE65635B1 (en) 1995-11-01
MD523G2 (ro) 1997-01-31

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