NZ236107A - 3 (substituted amino)-6-phenyl (and heterocyclyl)-1,2-diazine derivatives; preparatory processes and pharmaceutical compositions - Google Patents

3 (substituted amino)-6-phenyl (and heterocyclyl)-1,2-diazine derivatives; preparatory processes and pharmaceutical compositions

Info

Publication number
NZ236107A
NZ236107A NZ236107A NZ23610790A NZ236107A NZ 236107 A NZ236107 A NZ 236107A NZ 236107 A NZ236107 A NZ 236107A NZ 23610790 A NZ23610790 A NZ 23610790A NZ 236107 A NZ236107 A NZ 236107A
Authority
NZ
New Zealand
Prior art keywords
phenyl
active ingredient
compound
propyl
substituted
Prior art date
Application number
NZ236107A
Other languages
English (en)
Inventor
Robert Boigegrain
Roger Brodin
Jean Paul Kan
Dominique Olliero
Camille Georges Wermuth
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8915137A external-priority patent/FR2654727B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NZ236107A publication Critical patent/NZ236107A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ236107A 1989-11-17 1990-11-16 3 (substituted amino)-6-phenyl (and heterocyclyl)-1,2-diazine derivatives; preparatory processes and pharmaceutical compositions NZ236107A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8915137A FR2654727B1 (fr) 1989-11-17 1989-11-17 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR909007533A FR2663326B2 (fr) 1989-11-17 1990-06-15 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
NZ236107A true NZ236107A (en) 1992-10-28

Family

ID=26227673

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ236107A NZ236107A (en) 1989-11-17 1990-11-16 3 (substituted amino)-6-phenyl (and heterocyclyl)-1,2-diazine derivatives; preparatory processes and pharmaceutical compositions

Country Status (21)

Country Link
EP (1) EP0429344B1 (enrdf_load_stackoverflow)
JP (1) JPH03170465A (enrdf_load_stackoverflow)
KR (1) KR0164599B1 (enrdf_load_stackoverflow)
AR (1) AR247557A1 (enrdf_load_stackoverflow)
AT (1) ATE143010T1 (enrdf_load_stackoverflow)
AU (1) AU639043B2 (enrdf_load_stackoverflow)
CA (1) CA2030133A1 (enrdf_load_stackoverflow)
DE (1) DE69028602T2 (enrdf_load_stackoverflow)
DK (1) DK0429344T3 (enrdf_load_stackoverflow)
ES (1) ES2094146T3 (enrdf_load_stackoverflow)
FI (1) FI101881B1 (enrdf_load_stackoverflow)
FR (1) FR2663326B2 (enrdf_load_stackoverflow)
GR (1) GR3021933T3 (enrdf_load_stackoverflow)
HK (1) HK1000597A1 (enrdf_load_stackoverflow)
HU (2) HU207852B (enrdf_load_stackoverflow)
IE (1) IE75697B1 (enrdf_load_stackoverflow)
IL (1) IL96384A (enrdf_load_stackoverflow)
LV (1) LV11972B (enrdf_load_stackoverflow)
NO (1) NO178967C (enrdf_load_stackoverflow)
NZ (1) NZ236107A (enrdf_load_stackoverflow)
PT (1) PT95902B (enrdf_load_stackoverflow)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
CA2237273C (en) * 1996-01-15 2009-01-13 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
JP2001526263A (ja) * 1997-12-19 2001-12-18 アムジエン・インコーポレーテツド 置換ピリジン及びピリダジン化合物並びにそれらの医薬的使用
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP2004532628A (ja) 2001-03-23 2004-10-28 アドバンスド バイオニュートリション 生物活性蛋白質を含有する微生物を用いた水産養殖および農業における疾病制御の輸送
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
DE602006020330D1 (de) 2005-12-07 2011-04-07 Sumitomo Chemical Co Pyridazinverbindung und deren verwendung
FR2904314A1 (fr) * 2006-07-26 2008-02-01 Centre Nat Rech Scient Composes pyridaziniques et pyrroliques lineaires, procedes d'obtention et applications
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
EP4129986A4 (en) * 2020-03-27 2024-05-22 Astellas Pharma Inc. SUBSTITUTED PYRIDAZINE COMPOUND
EP4289823A4 (en) * 2021-02-08 2025-02-26 Medshine Discovery Inc. Substituted pyridazine phenol derivatives
TW202406550A (zh) 2022-08-03 2024-02-16 瑞士商諾華公司 Ｎｌｒｐ３炎性小體抑制劑

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3629929A1 (de) * 1986-09-03 1988-03-10 Thomae Gmbh Dr K Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
PT93060B (pt) * 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
IL96384A0 (en) 1991-08-16
NO904984L (no) 1991-05-21
HUT56078A (en) 1991-07-29
FI905663A0 (fi) 1990-11-15
IE904145A1 (en) 1991-05-22
EP0429344A1 (fr) 1991-05-29
PT95902A (pt) 1991-09-13
EP0429344B1 (fr) 1996-09-18
LV11972B (lv) 1998-04-20
DE69028602T2 (de) 1997-04-03
KR910009672A (ko) 1991-06-28
LV11972A (lv) 1998-02-20
FI101881B (fi) 1998-09-15
HK1000597A1 (en) 1998-04-09
ES2094146T3 (es) 1997-01-16
CA2030133C (enrdf_load_stackoverflow) 1991-05-18
NO178967B (no) 1996-04-01
FI905663A7 (fi) 1991-05-18
DK0429344T3 (enrdf_load_stackoverflow) 1997-03-03
AU639043B2 (en) 1993-07-15
FR2663326B2 (fr) 1992-10-16
GR3021933T3 (en) 1997-03-31
FI101881B1 (fi) 1998-09-15
JPH03170465A (ja) 1991-07-24
AU6667290A (en) 1991-05-23
IL96384A (en) 1995-10-31
ATE143010T1 (de) 1996-10-15
HU907178D0 (en) 1991-05-28
NO904984D0 (no) 1990-11-16
CA2030133A1 (en) 1991-05-18
DE69028602D1 (de) 1996-10-24
IE75697B1 (en) 1997-09-10
KR0164599B1 (ko) 1999-01-15
HU211351A9 (en) 1995-11-28
HU207852B (en) 1993-06-28
NO178967C (no) 1996-07-10
FR2663326A2 (fr) 1991-12-20
PT95902B (pt) 1998-01-30
AR247557A1 (es) 1995-01-31

Similar Documents

Publication Publication Date Title
NZ236107A (en) 3 (substituted amino)-6-phenyl (and heterocyclyl)-1,2-diazine derivatives; preparatory processes and pharmaceutical compositions
CA2050639C (en) Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
US5340822A (en) Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present
CA2029275A1 (en) Aromatic amine compounds, their method of preparation and pharmaceutical compositions in which they are present
PT664291E (pt) Composto de pirimidina
US5276036A (en) 3-(N-azabicycloalkyl)aminopyridazine derivatives and pharmaceutical compositions in which they are present
IL122159A (en) -4 Aril - 1phenylalkyl- 1, 2, 3, 6 - Tetrahydropyridines, their preparation and pharmaceuticals containing
MX2007010070A (es) Derivados de pirrolidin y piperidin acetileno para usarse como antagonistas de mglur5.
US4945096A (en) Treatment of a depressive state with 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivates
US5852019A (en) Pyrimidinylpyrazole derivatives
HK1000597B (en) Pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them
EP1411945A1 (en) Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists
CA2340230C (en) Pyridazinone derivatives having cell adhesion inhibiting activity
CA1144165A (en) N-pyrrolyl pyridazineamines
US6346622B1 (en) 2-substituted 1,2-benzisothiazole derivatives and their use as serotonin antagonists (5-HT1A, 5HT1B and 5-HT1D)
US5656631A (en) Pyridazine derivatives
JPH04234369A (ja) ６−アルキルピリダジン誘導体、調製方法およびそれらを含有する医薬組成物
JPH0616638A (ja) ピリジン化合物およびその医薬用途
AU2002321896A1 (en) Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists
NZ245411A (en) Aromatic substituted amines, amides and ureas