ES2094146T3 - Derivados de la piridazina, procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de la piridazina, procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2094146T3
ES2094146T3 ES90403239T ES90403239T ES2094146T3 ES 2094146 T3 ES2094146 T3 ES 2094146T3 ES 90403239 T ES90403239 T ES 90403239T ES 90403239 T ES90403239 T ES 90403239T ES 2094146 T3 ES2094146 T3 ES 2094146T3
Authority
ES
Spain
Prior art keywords
piridazine
derivatives
group
contain
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90403239T
Other languages
English (en)
Inventor
Robert Boigegrain
Roger Brodin
Jean-Paul Kan
Dominique Olliero
Camille Georges Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8915137A external-priority patent/FR2654727B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2094146T3 publication Critical patent/ES2094146T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION TIENE POR OBJETO UNOS DERIVADOS DE PIRIDAZINA DE FORMULA: EN LA CUAL: POR R$_{1}$ Y R$_{2}$ O UN RADICAL HETEROCICLICO TAL COMO EL PIRIDILO NO SUSTITUIDO POR UN CLORO, UN METILO O UN METOXI; $_{1}$ Y R$_{2}$ DESIGNAN CADA UNO INDEPENDIENTEMENTE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO TRIFLUOROMETILO, UN GRUPO HIDROXILO, UN GRUPO ALCOXI C$_{1}$-C$_{4}$ O UN GRUPO ALQUILO C$_{1}$-C$_{4}$. O RAMIFICADO EN C$_{1}$ -C$_{4}$, UN CICLOALQUILO EN C$_{3}$-C$_{7}$, UN BENCILO, UN FENETILO O EL RADICAL AR'', SIENDO AR'' UN FENILO SUSTITUIDO POR R$_{1}$ Y R$_{2}$; O UN METILO; C$_{1}$-C$_{6}$; EN C$_{1}$-C$_{6}$, O TAMBIEN R$_{5}$ Y R$_{6}$ CONSTITUYEN CON EL ATOMO DE NITROGENO AL QUE ESTAN LIGADOS UN HETEROCICLO ELEGIDO ENTRE LA MORFOLINA, LA PIRROLIDINA O LA PIPERIDINA; ASI COMO SUS SALES CON LOS ACIDOS MINERALES U ORGANICOS. APLICACION: MEDICAMENTOS ACTIVOS SOBRE LOS RECEPTORES COLINERGICOS DE TIPO M$_{1}$.
ES90403239T 1989-11-17 1990-11-16 Derivados de la piridazina, procedimiento de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2094146T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8915137A FR2654727B1 (fr) 1989-11-17 1989-11-17 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR909007533A FR2663326B2 (fr) 1989-11-17 1990-06-15 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
ES2094146T3 true ES2094146T3 (es) 1997-01-16

Family

ID=26227673

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90403239T Expired - Lifetime ES2094146T3 (es) 1989-11-17 1990-11-16 Derivados de la piridazina, procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Country Status (21)

Country Link
EP (1) EP0429344B1 (es)
JP (1) JPH03170465A (es)
KR (1) KR0164599B1 (es)
AR (1) AR247557A1 (es)
AT (1) ATE143010T1 (es)
AU (1) AU639043B2 (es)
CA (1) CA2030133A1 (es)
DE (1) DE69028602T2 (es)
DK (1) DK0429344T3 (es)
ES (1) ES2094146T3 (es)
FI (1) FI101881B (es)
FR (1) FR2663326B2 (es)
GR (1) GR3021933T3 (es)
HK (1) HK1000597A1 (es)
HU (2) HU207852B (es)
IE (1) IE75697B1 (es)
IL (1) IL96384A (es)
LV (1) LV11972B (es)
NO (1) NO178967C (es)
NZ (1) NZ236107A (es)
PT (1) PT95902B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
ATE203534T1 (de) * 1996-01-15 2001-08-15 Janssen Pharmaceutica Nv Angiogenesis hemmende pyridazinamine
EP1042293B9 (en) * 1997-12-19 2008-09-03 Amgen Inc. Substituted pyridine and pyridazine compounds and their pharmaceutical use
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
EP1381345B1 (en) 2001-03-23 2008-07-09 Advanced Bionutrition Corporation Delivery of disease control in aquaculture using yeasts containing bioactive proteins
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
DE602006020330D1 (de) * 2005-12-07 2011-04-07 Sumitomo Chemical Co Pyridazinverbindung und deren verwendung
FR2904314A1 (fr) * 2006-07-26 2008-02-01 Centre Nat Rech Scient Composes pyridaziniques et pyrroliques lineaires, procedes d'obtention et applications
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
CN115279739A (zh) * 2020-03-27 2022-11-01 安斯泰来制药株式会社 取代哒嗪化合物
US20240166610A1 (en) * 2021-02-08 2024-05-23 Medshine Discovery Inc. Substituted pyridazine phenol derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3629929A1 (de) * 1986-09-03 1988-03-10 Thomae Gmbh Dr K Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
PT93060B (pt) * 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique

Also Published As

Publication number Publication date
LV11972A (lv) 1998-02-20
HU211351A9 (en) 1995-11-28
FI101881B1 (fi) 1998-09-15
IE904145A1 (en) 1991-05-22
IL96384A0 (en) 1991-08-16
NO904984L (no) 1991-05-21
FR2663326A2 (fr) 1991-12-20
KR0164599B1 (ko) 1999-01-15
DE69028602D1 (de) 1996-10-24
EP0429344B1 (fr) 1996-09-18
GR3021933T3 (en) 1997-03-31
DK0429344T3 (es) 1997-03-03
LV11972B (lv) 1998-04-20
CA2030133C (es) 1991-05-18
HUT56078A (en) 1991-07-29
PT95902A (pt) 1991-09-13
NO178967C (no) 1996-07-10
IL96384A (en) 1995-10-31
FI905663A0 (fi) 1990-11-15
KR910009672A (ko) 1991-06-28
AR247557A1 (es) 1995-01-31
ATE143010T1 (de) 1996-10-15
FR2663326B2 (fr) 1992-10-16
HU907178D0 (en) 1991-05-28
DE69028602T2 (de) 1997-04-03
AU6667290A (en) 1991-05-23
NO904984D0 (no) 1990-11-16
NO178967B (no) 1996-04-01
IE75697B1 (en) 1997-09-10
EP0429344A1 (fr) 1991-05-29
JPH03170465A (ja) 1991-07-24
HK1000597A1 (en) 1998-04-09
CA2030133A1 (en) 1991-05-18
PT95902B (pt) 1998-01-30
FI101881B (fi) 1998-09-15
FI905663A (fi) 1991-05-18
NZ236107A (en) 1992-10-28
HU207852B (en) 1993-06-28
AU639043B2 (en) 1993-07-15

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