BR9811273A - Derivados de benzimidazol - Google Patents
Derivados de benzimidazolInfo
- Publication number
- BR9811273A BR9811273A BR9811273-2A BR9811273A BR9811273A BR 9811273 A BR9811273 A BR 9811273A BR 9811273 A BR9811273 A BR 9811273A BR 9811273 A BR9811273 A BR 9811273A
- Authority
- BR
- Brazil
- Prior art keywords
- benzimidazole derivatives
- salt
- represented
- alkyl group
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE BENZIMIDAZOL"<D>. Um novo derivado de benzimidazol ou um sal dele é provido, que é representado pela fórmula: onde R~ 1~ representa um grupo alquila, etc., R~ 2~ representa um grupo alquila inferior aromático insubstituído, R~ 3~ representa um grupo aluila, etc., e-X-é representado pela seguinte fórmula (V): etc. Este derivdo ou um sal dele é útil como medicamento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18769697 | 1997-06-27 | ||
JP7635798 | 1998-03-25 | ||
PCT/JP1998/002885 WO1999000373A1 (fr) | 1997-06-27 | 1998-06-26 | Derives de benzimidazole |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811273A true BR9811273A (pt) | 2000-07-18 |
Family
ID=26417500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811273-2A BR9811273A (pt) | 1997-06-27 | 1998-06-26 | Derivados de benzimidazol |
Country Status (15)
Country | Link |
---|---|
US (1) | US6420409B1 (pt) |
EP (1) | EP1020452A4 (pt) |
KR (1) | KR20010014166A (pt) |
CN (1) | CN1135224C (pt) |
AR (1) | AR016108A1 (pt) |
AU (1) | AU748541B2 (pt) |
BR (1) | BR9811273A (pt) |
CA (1) | CA2294505A1 (pt) |
HK (1) | HK1028246A1 (pt) |
HU (1) | HUP0002324A3 (pt) |
IL (1) | IL133674A0 (pt) |
RU (1) | RU2243968C2 (pt) |
TR (1) | TR199903277T2 (pt) |
TW (1) | TW453999B (pt) |
WO (1) | WO1999000373A1 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010014183A (ko) * | 1997-06-27 | 2001-02-26 | Fujisawa Pharmaceutical Co | 술폰아미드 화합물 및 그의 의약 용도 |
CN1150167C (zh) * | 1998-04-06 | 2004-05-19 | 藤泽药品工业株式会社 | 吲哚衍生物 |
WO2000028991A1 (fr) * | 1998-11-13 | 2000-05-25 | Fujisawa Pharmaceutical Co., Ltd. | Remedes contre le syndrome des ovaires polykystiques |
US6869950B1 (en) | 1998-12-24 | 2005-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
US6525067B1 (en) | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
EP1149583A3 (en) * | 2000-04-13 | 2001-11-14 | Pfizer Products Inc. | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
US6943171B2 (en) | 2001-11-09 | 2005-09-13 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase V inhibitors |
EP1452176A4 (en) * | 2001-12-03 | 2009-01-21 | Takeda Pharmaceutical | MEANS FOR IMPROVING INSULIN RESISTANCE |
US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
NZ536610A (en) * | 2002-05-03 | 2009-02-28 | Israel Inst Biolog Res | Spiro agonists and antagonists of M1 and M3 muscarinic receptors for treatment of central and peripheral nervous system disorders |
AU2003902860A0 (en) * | 2003-06-06 | 2003-06-26 | Daicel Chemical Industries, Ltd | Benzimidazole compounds |
US20050197376A1 (en) * | 2004-03-02 | 2005-09-08 | Fujisawa Pharmaceutical Co. Ltd. | Concomitant drugs |
EP1983992A4 (en) * | 2006-01-19 | 2010-08-18 | Abbott Lab | 2-IMINO-BENZIMIDAZOLES |
WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
CN105130855B (zh) | 2009-12-07 | 2018-05-25 | 约翰斯霍普金斯大学 | 二酰基化的羟基胺衍生物及其用途 |
CN105919987B (zh) * | 2009-12-07 | 2020-04-03 | 约翰斯霍普金斯大学 | N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物及其用途 |
JP5990106B2 (ja) * | 2011-01-28 | 2016-09-07 | 佐藤製薬株式会社 | 縮環化合物 |
RU2018120308A (ru) * | 2015-12-11 | 2019-12-03 | Тейдзин Фарма Лимитед | Производное аминоазола |
WO2017192728A1 (en) | 2016-05-03 | 2017-11-09 | Virginia Commonwealth University | Heteroatom -doped porous carbons for clean energy applications and methods for their synthesis |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE676196C (de) | 1936-08-21 | 1939-05-30 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von Imidazolverbindungen |
US3152142A (en) | 1962-05-24 | 1964-10-06 | Dow Chemical Co | Benzimidazole compounds |
FR2291749A1 (fr) | 1974-11-20 | 1976-06-18 | Delalande Sa | Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique |
JPS51133267A (en) | 1975-05-08 | 1976-11-18 | Lilly Co Eli | Substituted 11sulphonyl benzimidazole |
US4179505A (en) | 1977-03-30 | 1979-12-18 | Janssen Pharmaceutica N.V. | 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives |
US4243806A (en) | 1979-06-13 | 1981-01-06 | Janssen Pharmaceutica N.V. | 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives |
GB2053215B (en) | 1979-06-25 | 1983-04-07 | May & Baker Ltd | Benzimidazole derivatives |
JPS625966A (ja) | 1985-07-03 | 1987-01-12 | Nippon Shinyaku Co Ltd | ベンズイミダゾ−ル誘導体 |
NZ221729A (en) | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
CA2004911A1 (en) | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO1991016313A1 (en) | 1990-04-13 | 1991-10-31 | Smithkline Beecham Corporation | Substituted benzimidazoles |
US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
US5703110A (en) | 1990-04-27 | 1997-12-30 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
DE4023369A1 (de) * | 1990-07-23 | 1992-01-30 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
RU1836357C (ru) | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами |
US5591762A (en) | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
DE4224133A1 (de) * | 1992-07-22 | 1994-01-27 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5594003A (en) | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
SI9210098B (sl) | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
US5602127A (en) | 1991-02-06 | 1997-02-11 | Karl Thomae Gmbh | (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists |
US5407835A (en) | 1991-07-31 | 1995-04-18 | Abbott Laboratories | Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids |
GB9121776D0 (en) | 1991-10-14 | 1991-11-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives and process for preparation thereof |
DE4237557A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
JPH0853424A (ja) | 1994-08-11 | 1996-02-27 | Kureha Chem Ind Co Ltd | ベンズイミダゾールスルホン酸アミド誘導体 |
GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
AU722514B2 (en) * | 1995-12-28 | 2000-08-03 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
-
1998
- 1998-06-25 TW TW087110304A patent/TW453999B/zh not_active IP Right Cessation
- 1998-06-26 HU HU0002324A patent/HUP0002324A3/hu unknown
- 1998-06-26 US US09/446,749 patent/US6420409B1/en not_active Expired - Fee Related
- 1998-06-26 CA CA002294505A patent/CA2294505A1/en not_active Abandoned
- 1998-06-26 BR BR9811273-2A patent/BR9811273A/pt not_active IP Right Cessation
- 1998-06-26 TR TR1999/03277T patent/TR199903277T2/xx unknown
- 1998-06-26 KR KR1019997012237A patent/KR20010014166A/ko not_active Application Discontinuation
- 1998-06-26 CN CNB988085798A patent/CN1135224C/zh not_active Expired - Fee Related
- 1998-06-26 WO PCT/JP1998/002885 patent/WO1999000373A1/ja not_active Application Discontinuation
- 1998-06-26 IL IL13367498A patent/IL133674A0/xx unknown
- 1998-06-26 AR ARP980103128A patent/AR016108A1/es unknown
- 1998-06-26 EP EP98929723A patent/EP1020452A4/en not_active Withdrawn
- 1998-06-26 RU RU2000101811/04A patent/RU2243968C2/ru not_active IP Right Cessation
- 1998-06-26 AU AU79346/98A patent/AU748541B2/en not_active Ceased
-
2000
- 2000-11-22 HK HK00107463A patent/HK1028246A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1135224C (zh) | 2004-01-21 |
CN1268123A (zh) | 2000-09-27 |
WO1999000373A8 (fr) | 2000-07-20 |
HUP0002324A3 (en) | 2001-07-30 |
WO1999000373A1 (fr) | 1999-01-07 |
AU748541B2 (en) | 2002-06-06 |
KR20010014166A (ko) | 2001-02-26 |
AU7934698A (en) | 1999-01-19 |
HUP0002324A2 (hu) | 2001-05-28 |
TW453999B (en) | 2001-09-11 |
EP1020452A4 (en) | 2003-04-02 |
RU2243968C2 (ru) | 2005-01-10 |
EP1020452A1 (en) | 2000-07-19 |
CA2294505A1 (en) | 1999-01-07 |
TR199903277T2 (xx) | 2000-07-21 |
US6420409B1 (en) | 2002-07-16 |
IL133674A0 (en) | 2001-04-30 |
HK1028246A1 (en) | 2001-02-09 |
AR016108A1 (es) | 2001-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1914 DE 11/09/2007. |