BR0115318A - Derivados de (diidro)isoquinolina como inibidores da fosfodiesterase - Google Patents
Derivados de (diidro)isoquinolina como inibidores da fosfodiesteraseInfo
- Publication number
- BR0115318A BR0115318A BR0115318-8A BR0115318A BR0115318A BR 0115318 A BR0115318 A BR 0115318A BR 0115318 A BR0115318 A BR 0115318A BR 0115318 A BR0115318 A BR 0115318A
- Authority
- BR
- Brazil
- Prior art keywords
- dihydro
- phosphodiesterase inhibitors
- isoquinoline derivatives
- derivatives
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
Abstract
"DERIVADOS DE (DIIDRO)ISOQUINOLINA COMO INIBIDORES DA FOSFODIESTERASE". Compostos de 3,4-diidroisoquinolina e isoquinolina de fórmula I, em que Ar representa um radical fenila das fórmulas IIa, IIb ou IIc, são novos inibidores da PDE7 eficazes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00124774 | 2000-11-14 | ||
DE10103547 | 2001-01-26 | ||
PCT/EP2001/012918 WO2002040450A1 (en) | 2000-11-14 | 2001-11-08 | (dihydro)isoquinoline derivatives as phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0115318A true BR0115318A (pt) | 2004-02-03 |
Family
ID=26008337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0115318-8A BR0115318A (pt) | 2000-11-14 | 2001-11-08 | Derivados de (diidro)isoquinolina como inibidores da fosfodiesterase |
Country Status (16)
Country | Link |
---|---|
US (1) | US6818651B2 (pt) |
EP (1) | EP1337515A1 (pt) |
JP (1) | JP2004513938A (pt) |
KR (1) | KR20030045184A (pt) |
CN (1) | CN1474812A (pt) |
AU (2) | AU2002229541B2 (pt) |
BR (1) | BR0115318A (pt) |
CA (1) | CA2428527A1 (pt) |
CZ (1) | CZ20031334A3 (pt) |
HU (1) | HUP0400011A3 (pt) |
IL (1) | IL155067A0 (pt) |
MX (1) | MXPA03004262A (pt) |
NZ (1) | NZ525147A (pt) |
PL (1) | PL361144A1 (pt) |
SK (1) | SK5782003A3 (pt) |
WO (1) | WO2002040450A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1597385A1 (en) * | 2002-11-13 | 2005-11-23 | Bayer HealthCare AG | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 7A1 (PDE7a1) |
JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するイミダゾトリアジノン誘導体 |
JP2006219373A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するピリジニルピラゾロピリミジノン誘導体 |
DK2433943T3 (da) | 2004-07-01 | 2013-12-16 | Daiichi Sankyo Co Ltd | Mellemprodukter til thienopyrazol-derivater med PDE7-inhibitorisk aktivitet |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP1928437A2 (en) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
WO2007067946A2 (en) * | 2005-12-07 | 2007-06-14 | The Regents Of The University Of California | Diagnosis and treatment of chronic lymphocytic leukemia (cll) |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
DE102006012544A1 (de) * | 2006-03-18 | 2007-09-27 | Sanofi-Aventis | Substituierte 1-Amino 4-phenyl-dihydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2009002496A (es) * | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
WO2008119057A2 (en) | 2007-03-27 | 2008-10-02 | Omeros Corporation | The use of pde7 inhibitors for the treatment of movement disorders |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
CZ20106A3 (cs) * | 2010-01-05 | 2011-08-10 | Zentiva, K. S | Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu |
US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
CN103547267A (zh) | 2010-11-08 | 2014-01-29 | 奥默罗斯公司 | 使用pde7抑制剂治疗成瘾和冲动控制障碍 |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863870A (en) | 1988-03-10 | 1989-09-05 | Bio-Affinity Systems, Inc. | Method of thioacylation peptide sequencing with alcoholysis of thiazolinones |
GB9027055D0 (en) | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
GB9222253D0 (en) | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
GB9322828D0 (en) | 1993-11-05 | 1993-12-22 | Sandoz Ltd | Organic compounds |
AU5652698A (en) | 1996-11-12 | 1998-06-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors |
PT988302E (pt) | 1997-06-03 | 2003-07-31 | Altana Pharma Ag | Benzonaftiridinas |
AU2790999A (en) | 1998-03-03 | 1999-09-20 | Merck & Co., Inc. | Fused piperidine substituted arylsulfonamides as beta3-agonists |
-
2001
- 2001-11-08 NZ NZ525147A patent/NZ525147A/en unknown
- 2001-11-08 IL IL15506701A patent/IL155067A0/xx unknown
- 2001-11-08 MX MXPA03004262A patent/MXPA03004262A/es unknown
- 2001-11-08 CZ CZ20031334A patent/CZ20031334A3/cs unknown
- 2001-11-08 CA CA002428527A patent/CA2428527A1/en not_active Abandoned
- 2001-11-08 AU AU2002229541A patent/AU2002229541B2/en not_active Ceased
- 2001-11-08 PL PL01361144A patent/PL361144A1/xx unknown
- 2001-11-08 SK SK578-2003A patent/SK5782003A3/sk unknown
- 2001-11-08 US US10/381,461 patent/US6818651B2/en not_active Expired - Fee Related
- 2001-11-08 CN CNA018187641A patent/CN1474812A/zh active Pending
- 2001-11-08 BR BR0115318-8A patent/BR0115318A/pt not_active IP Right Cessation
- 2001-11-08 KR KR10-2003-7006381A patent/KR20030045184A/ko not_active Application Discontinuation
- 2001-11-08 AU AU2954102A patent/AU2954102A/xx active Pending
- 2001-11-08 JP JP2002542778A patent/JP2004513938A/ja not_active Ceased
- 2001-11-08 EP EP01990399A patent/EP1337515A1/en not_active Withdrawn
- 2001-11-08 WO PCT/EP2001/012918 patent/WO2002040450A1/en active Application Filing
- 2001-11-08 HU HU0400011A patent/HUP0400011A3/hu unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA03004262A (es) | 2003-09-22 |
CA2428527A1 (en) | 2002-05-23 |
JP2004513938A (ja) | 2004-05-13 |
HUP0400011A3 (en) | 2008-03-28 |
IL155067A0 (en) | 2003-10-31 |
AU2002229541B2 (en) | 2007-01-18 |
SK5782003A3 (en) | 2003-10-07 |
KR20030045184A (ko) | 2003-06-09 |
EP1337515A1 (en) | 2003-08-27 |
WO2002040450A1 (en) | 2002-05-23 |
US20040044212A1 (en) | 2004-03-04 |
NZ525147A (en) | 2004-10-29 |
US6818651B2 (en) | 2004-11-16 |
HUP0400011A2 (hu) | 2004-05-28 |
PL361144A1 (en) | 2004-09-20 |
AU2954102A (en) | 2002-05-27 |
CN1474812A (zh) | 2004-02-11 |
CZ20031334A3 (cs) | 2003-09-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0115318A (pt) | Derivados de (diidro)isoquinolina como inibidores da fosfodiesterase | |
TR200200579T2 (tr) | Amino-tirazolpiridin türevleri. | |
DE60218458D1 (de) | Isochinolinon derivate als parp inhibitoren | |
BR0108396A (pt) | Derivados de pirimidina-4-0na como inibidores de ldl-pla(2) | |
ES2182234T3 (es) | Inhibidores de metaloproteasa. | |
NZ509207A (en) | Thiobenzimidazole derivative compounds, and usage as chymase activity inhibitors | |
PT1193270E (pt) | Pirrolobenzodiazepinas | |
PT1140944E (pt) | Derivados de epotilona e sua utilizacao como agentes antitumorais | |
TR199902606T2 (xx) | Farnesil transferaz� engelleyici kinazolinonlar. | |
AR006390A1 (es) | Derivados de lactama | |
ES2186874T3 (es) | Analogos de m-amidinofenilo como inhibidores del factor xa. | |
BR0316609A (pt) | Sinomenina e compostos de sinomenina, sìntese e uso | |
BR0112370A (pt) | Derivados de glutaramida substituìda com ciclopentila como inibidores de endopeptidase neutra | |
NZ507835A (en) | Heterocyclic derivatives which inhibit factor XA | |
ES2193414T3 (es) | Dihidrobenzofuranos sustituidos como inhibidores de la pde. | |
TR200403436T2 (tr) | Kristalin 1-metilkarbapenem türevleri. | |
WO2000005214A3 (en) | Isoquinolines as urokinase inhibitors | |
BR0016553A (pt) | 2-(1h-indol-3-il)-2-oxo-acetamidas com atividades antitumor | |
BR0113583A (pt) | 2-guanidino-4-arilquinazolinas | |
BR0214875A (pt) | 2-guanidino-4-heterociclil quinazolinas | |
BR9902084A (pt) | Heterociclos. | |
BR0115996A (pt) | Sulfamidotienopirimidinas | |
BRPI0415034A (pt) | derivados de aminopiridina como inibidores de não-sintase induzìveis | |
DE60036558D1 (de) | Phthalazinon-derivate als pde 4 hemmer | |
ATE273307T1 (de) | Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS. |