BR0214875A - 2-guanidino-4-heterociclil quinazolinas - Google Patents
2-guanidino-4-heterociclil quinazolinasInfo
- Publication number
- BR0214875A BR0214875A BR0214875-7A BR0214875A BR0214875A BR 0214875 A BR0214875 A BR 0214875A BR 0214875 A BR0214875 A BR 0214875A BR 0214875 A BR0214875 A BR 0214875A
- Authority
- BR
- Brazil
- Prior art keywords
- guanidino
- quinazolines
- heterocyclyl
- formula
- quinazolins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"2-GUANIDINO-4-HETEROCICLIL QUINAZOLINAS". A invenção se refere a compostos da fórmula (I): nos quais (Y) é a fórmula (II): ou a fórmula (III): e Het, R^ 1^, R^ 2^, R^ 5^, R^ 6^, R^ 7^ e R^ 8^ São como definidos acima, e sais e solvatos dos mesmos, e ao uso dos mesmos como inibidores de NHE-3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10161767A DE10161767A1 (de) | 2001-12-15 | 2001-12-15 | 2-Guanidino-4-heterocyclyl-chinazoline |
PCT/EP2002/013061 WO2003051866A1 (de) | 2001-12-15 | 2002-11-21 | 2-guanidino-4-heterocyclyl-chinazoline |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0214875A true BR0214875A (pt) | 2004-12-28 |
Family
ID=7709413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0214875-7A BR0214875A (pt) | 2001-12-15 | 2002-11-21 | 2-guanidino-4-heterociclil quinazolinas |
Country Status (11)
Country | Link |
---|---|
US (1) | US20050113396A1 (pt) |
EP (1) | EP1453823A1 (pt) |
KR (1) | KR20040065233A (pt) |
AR (1) | AR037821A1 (pt) |
AU (1) | AU2002342918A1 (pt) |
BR (1) | BR0214875A (pt) |
CA (1) | CA2470030A1 (pt) |
DE (1) | DE10161767A1 (pt) |
MX (1) | MXPA04005692A (pt) |
PL (1) | PL370174A1 (pt) |
WO (1) | WO2003051866A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7241775B2 (en) | 2003-03-24 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines |
DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
MX2011001821A (es) | 2008-09-02 | 2011-03-25 | Sanofi Aventis | Aminoindanos sustituidos y sus analogos, y el uso farmaceutico de los mismos. |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
EP2384318B1 (en) | 2008-12-31 | 2017-11-15 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US20150336892A1 (en) | 2012-08-21 | 2015-11-26 | Ardelyx, Inc | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
KR102287207B1 (ko) | 2013-04-12 | 2021-08-09 | 알데릭스, 인코포레이티드 | Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법 |
ME03311B (me) | 2014-07-25 | 2019-10-20 | Taisho Pharmaceutical Co Ltd | Fenil teтrahidroizokvinolinsko jedinjenje supsтituisano heteroarilom |
MX2019008170A (es) | 2017-01-09 | 2020-02-07 | Ardelyx Inc | Compuestos útiles para tratar transtornos del tracto gastrointestinal. |
EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
EA202090438A1 (ru) | 2017-08-04 | 2020-06-15 | Арделикс, Инк. | Производные глицерретиновой кислоты для лечения гиперкалиемии |
AU2020218255A1 (en) | 2019-02-07 | 2021-09-09 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US395526A (en) * | 1889-01-01 | Tenoning-ivjachine | ||
US396495A (en) * | 1889-01-22 | Ink-bottle and attachment therefor | ||
NL131733C (pt) * | 1961-06-20 | |||
NL292083A (pt) * | 1962-09-18 | |||
US3950526A (en) * | 1970-04-20 | 1976-04-13 | Sumitomo Chemical Company, Limited | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation |
BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US3900476A (en) * | 1973-05-17 | 1975-08-19 | Upjohn Co | 2(2'-pyrimidylamino)quinazolines and their preparation |
US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
IL102764A0 (en) * | 1991-08-16 | 1993-01-31 | Merck & Co Inc | Quinazoline derivatives,and pharmaceutical compositions containing them |
DE19633966A1 (de) * | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10019062A1 (de) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren |
KR100383080B1 (ko) * | 2000-09-05 | 2003-05-12 | 주식회사 포스코 | 조절된 아민기 밀도와 공간을 제공하는 분자층을 표면에포함하는 기질 및 이의 제조방법 |
US20030139431A1 (en) * | 2001-09-24 | 2003-07-24 | Kawakami Joel K. | Guanidines which are agonist/antagonist ligands for neuropeptide FF (NPFF) receptors |
-
2001
- 2001-12-15 DE DE10161767A patent/DE10161767A1/de not_active Withdrawn
-
2002
- 2002-11-21 WO PCT/EP2002/013061 patent/WO2003051866A1/de not_active Application Discontinuation
- 2002-11-21 CA CA002470030A patent/CA2470030A1/en not_active Abandoned
- 2002-11-21 US US10/498,806 patent/US20050113396A1/en not_active Abandoned
- 2002-11-21 AU AU2002342918A patent/AU2002342918A1/en not_active Abandoned
- 2002-11-21 PL PL02370174A patent/PL370174A1/xx unknown
- 2002-11-21 EP EP02779568A patent/EP1453823A1/de not_active Withdrawn
- 2002-11-21 BR BR0214875-7A patent/BR0214875A/pt not_active Application Discontinuation
- 2002-11-21 KR KR10-2004-7008399A patent/KR20040065233A/ko not_active Application Discontinuation
- 2002-11-21 MX MXPA04005692A patent/MXPA04005692A/es unknown
- 2002-12-13 AR ARP020104838A patent/AR037821A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20050113396A1 (en) | 2005-05-26 |
MXPA04005692A (es) | 2004-12-06 |
KR20040065233A (ko) | 2004-07-21 |
AU2002342918A1 (en) | 2003-06-30 |
CA2470030A1 (en) | 2003-06-26 |
PL370174A1 (en) | 2005-05-16 |
EP1453823A1 (de) | 2004-09-08 |
DE10161767A1 (de) | 2003-06-26 |
AR037821A1 (es) | 2004-12-09 |
WO2003051866A1 (de) | 2003-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |