BR0313566A - Composto de 4-nitroimidazol 1-substituìdo, método para preparar um composto de 4-nitroimidazol, método para preparar um composto de 4-nitroimidazol 1-substituìdo, derivado de 4-nitroimidazol, e, composto - Google Patents

Composto de 4-nitroimidazol 1-substituìdo, método para preparar um composto de 4-nitroimidazol, método para preparar um composto de 4-nitroimidazol 1-substituìdo, derivado de 4-nitroimidazol, e, composto

Info

Publication number
BR0313566A
BR0313566A BR0313566-7A BR0313566A BR0313566A BR 0313566 A BR0313566 A BR 0313566A BR 0313566 A BR0313566 A BR 0313566A BR 0313566 A BR0313566 A BR 0313566A
Authority
BR
Brazil
Prior art keywords
nitroimidazole
compound
substituted
preparing
nitroimidazole compound
Prior art date
Application number
BR0313566-7A
Other languages
English (en)
Inventor
Fumitaka Goto
Noriaki Takemura
Tadaaki Otani
Takeshi Hasegawa
Hidetsugu Tsubouchi
Naoto Utsumi
Shigekazu Fujita
Hideaki Kiroda
Takuya Shitsuta
Hirofumi Sasaki
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BR0313566A publication Critical patent/BR0313566A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Abstract

"COMPOSTO DE 4-NITROIMIDAZOL 1-SUBSTITUìDO, MéTODO PARA PREPARAR UM COMPOSTO DE 4-NITROIMIDAZOL, MéTODO PARA PREPARAR UM COMPOSTO DE 4-NITROIMIDAZOL 1-SUBSTITUìDO DERIVADO DE 4-NITROIMIDAZOL E COMPOSTO". Um composto de 4-nitroimidazol l-substituído representado pela fórmula geral (1): (1) em que R representa hidrogênio, alquila inferior substituída por alcóxi inferior, alquila inferior substituída por fenil(alcóxi inferior), alquila inferior substituída por ciano, fenil(alquila inferior) opcionalmente tendo como um alcóxi inferior substituinte no anel fenila, ou um grupo representado por -CH~ 2~R^ A^; e X representa halogênio ou um grupo representado por S(O)~ n~-R~ 1^; ou um sal do composto. O composto da fórmula geral (1) é útil como um intermediário para vários medicamentos e produtos químicos agrícolas, especialmente como um intermediário para agentes antituberculares.
BR0313566-7A 2002-10-15 2003-10-14 Composto de 4-nitroimidazol 1-substituìdo, método para preparar um composto de 4-nitroimidazol, método para preparar um composto de 4-nitroimidazol 1-substituìdo, derivado de 4-nitroimidazol, e, composto BR0313566A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002299896 2002-10-15
JP2003037914 2003-02-17
PCT/JP2003/013134 WO2004035547A1 (ja) 2002-10-15 2003-10-14 １位置換―４―ニトロイミダゾール化合物及びその製造法

Publications (1)

Publication Number Publication Date
BR0313566A true BR0313566A (pt) 2005-06-21

Family

ID=32109445

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313566-7A BR0313566A (pt) 2002-10-15 2003-10-14 Composto de 4-nitroimidazol 1-substituìdo, método para preparar um composto de 4-nitroimidazol, método para preparar um composto de 4-nitroimidazol 1-substituìdo, derivado de 4-nitroimidazol, e, composto

Country Status (17)

Country Link
US (4) US7368579B2 (pt)
EP (2) EP2644599B1 (pt)
JP (1) JP5014315B2 (pt)
KR (1) KR100655670B1 (pt)
AR (1) AR041605A1 (pt)
AU (1) AU2003301282B2 (pt)
BR (1) BR0313566A (pt)
CA (1) CA2494710C (pt)
EG (1) EG24885A (pt)
ES (1) ES2526892T3 (pt)
HK (2) HK1083830A1 (pt)
MX (1) MXPA05002414A (pt)
MY (1) MY145079A (pt)
PL (1) PL375103A1 (pt)
RU (1) RU2324682C2 (pt)
TW (2) TWI331607B (pt)
WO (1) WO2004035547A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368579B2 (en) * 2002-10-15 2008-05-06 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and process for producing the same
KR100851802B1 (ko) 2003-10-31 2008-08-13 오쓰까 세이야꾸 가부시키가이샤 결핵의 치료를 위한2,3-디히드로-6-니트로이미다조[2,1-ｂ]옥사졸 화합물
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
TW200624422A (en) * 2004-09-27 2006-07-16 Otsuka Pharma Co Ltd Process for production of 2-chloro-4-nitroimidazole
CN100338039C (zh) * 2004-11-29 2007-09-19 南京圣和药业有限公司 奥硝唑光学对映体的制备及纯化方法
DE602006018617D1 (de) * 2005-07-28 2011-01-13 Otsuka Pharma Co Ltd Pharmazeutische zusammensetzung mit 2,3-dihydro-6-nitroimidazoä2,1-büoxazolderivaten
AR070301A1 (es) * 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
JP5525515B2 (ja) * 2008-08-21 2014-06-18 デイナミート ノーベル ゲゼルシャフト ミット ベシュレンクテル ハフツング エクスプロジーフシュトッフ− ウント ジステームテヒニク ２−ハロ−４−ニトロイミダゾール及びその中間体の製造方法
TW201200523A (en) 2010-01-29 2012-01-01 Otsuka Pharma Co Ltd Synthetic intermediate of oxazole compound and method for producing the same
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
CN103396369B (zh) * 2013-08-14 2016-03-23 盐城工学院 一种制备2-氯-4-硝基咪唑的方法
EP3615530B1 (en) 2017-04-26 2021-04-14 Basf Se Substituted succinimide derivatives as pesticides
EP3696177A1 (en) 2019-02-12 2020-08-19 Basf Se Heterocyclic compounds for the control of invertebrate pests
CN113874341A (zh) * 2019-04-01 2021-12-31 科学与工业研究委员会 制备作为有用中间体的1，1-二烷基乙烷-1，2-二醇的衍生物的方法
CN113767095A (zh) 2019-05-01 2021-12-07 勃林格殷格翰国际有限公司 (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US3341548A (en) * 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
US3435049A (en) * 1965-05-19 1969-03-25 Hoffmann La Roche Nitroimidazole derivatives
DE2414280C2 (de) * 1974-03-25 1981-12-17 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 1-Methyl-5-nitroimidazolen
US4183941A (en) * 1978-08-21 1980-01-15 John R. A. Simoons Treatment of rheumatoid arthritis and related diseases
ES2054035T3 (es) * 1988-01-15 1994-08-01 Rhone Poulenc Sante Procedimiento para la preparacion de alquil-1 nitro-5 imidazoles.
US5344937A (en) * 1993-04-20 1994-09-06 Eli Lilly And Company Alkyl substituted nitroimidazole acetic acids
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TWI347946B (en) * 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
US7368579B2 (en) * 2002-10-15 2008-05-06 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and process for producing the same
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound

Also Published As

Publication number Publication date
CA2494710A1 (en) 2004-04-29
AR041605A1 (es) 2005-05-26
WO2004035547A1 (ja) 2004-04-29
RU2005114534A (ru) 2006-01-20
HK1083830A1 (en) 2006-08-11
EG24885A (en) 2010-12-06
TW200838855A (en) 2008-10-01
KR20050046013A (ko) 2005-05-17
US7368579B2 (en) 2008-05-06
US20080200689A1 (en) 2008-08-21
US20080097107A1 (en) 2008-04-24
JP2009102329A (ja) 2009-05-14
EP1553088A4 (en) 2011-03-02
US7807843B2 (en) 2010-10-05
US20060079697A1 (en) 2006-04-13
KR100655670B1 (ko) 2007-02-28
ES2526892T3 (es) 2015-01-16
EP2644599A1 (en) 2013-10-02
MXPA05002414A (es) 2005-06-22
AU2003301282B2 (en) 2009-04-30
EP1553088A1 (en) 2005-07-13
US20120130082A1 (en) 2012-05-24
MY145079A (en) 2011-12-15
TW200410943A (en) 2004-07-01
AU2003301282A1 (en) 2004-05-04
PL375103A1 (en) 2005-11-28
TWI331607B (en) 2010-10-11
CA2494710C (en) 2011-05-03
JP5014315B2 (ja) 2012-08-29
US8129544B2 (en) 2012-03-06
EP2644599B1 (en) 2014-12-10
RU2324682C2 (ru) 2008-05-20
HK1188993A1 (en) 2014-05-23

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.