HUP0002324A2 - Benzimidazolszármazékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Benzimidazolszármazékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0002324A2
HUP0002324A2 HU0002324A HUP0002324A HUP0002324A2 HU P0002324 A2 HUP0002324 A2 HU P0002324A2 HU 0002324 A HU0002324 A HU 0002324A HU P0002324 A HUP0002324 A HU P0002324A HU P0002324 A2 HUP0002324 A2 HU P0002324A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
aralkyl
alkenyl
alkoxy
Prior art date
Application number
HU0002324A
Other languages
English (en)
Inventor
Takahiro Hiramura
Takafumi Imoto
Akira Katayama
Hiroshi Kayakiri
Masahiro Nishikawa
Teruo Oku
Osamu Onomura
Hitoshi Sawada
Noritsugu Yamasaki
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HUP0002324A2 publication Critical patent/HUP0002324A2/hu
Publication of HUP0002324A3 publication Critical patent/HUP0002324A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A találmány szerinti új vegyületek (n) általánosképletében R1 jelentése hidrogénatom, alkilcsoport, alkoxicsoport vagyalkil-tio-csoport, R2 jelentése aralkil- vagy heteroaralkil csoport,amely adott esetben, egy vagy több halogénatom, alkilcsoport, halogén-alkil-csoport, nitrocsoport, alkoxi-karbonil-csoport, aromás csoport,aralkil-oxi-csoport, cikloalkil-oxi-alkil-csoport, aralkilcsoport,aralkenilcsoport, aralkinilcsoport, aromás-oxi-alkilcsoport,cikloalkil-alkil-oxi-csoport, alkenilcsoport, alkoxi-csoport, alkil-tio-csoport, alkán-szulfinil-csoport, alkán-szulfonil-csoport ésalkán-szulfonil-karbamoil-csoport közül megválasztott szubsztituensselszubsztituálva lehet, R3 jelentése alkilcsoport, hidroxi-alkil-csoport, alkenilcsoport, aromás csoport, halogénezett aromás csoport,alkil-aril-csoport, alkenil-aril-csoport, aralkilcsoport vagyaralkenilcsoport, -X- jelentése (II)-(VI) képletű csoport. A találmánykiterjed a fenti vegyületeket tartalmazó gyógyszerkészítményekre,amelyek a vér cukorszintjét csökkentő vagy PDE5 inhibitor hatássalrendelkeznek. Ó
HU0002324A 1997-06-27 1998-06-26 Benzimidazole derivatives and pharmaceutical compositions containing them HUP0002324A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18769697 1997-06-27
JP7635798 1998-03-25
PCT/JP1998/002885 WO1999000373A1 (fr) 1997-06-27 1998-06-26 Derives de benzimidazole

Publications (2)

Publication Number Publication Date
HUP0002324A2 true HUP0002324A2 (hu) 2001-05-28
HUP0002324A3 HUP0002324A3 (en) 2001-07-30

Family

ID=26417500

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002324A HUP0002324A3 (en) 1997-06-27 1998-06-26 Benzimidazole derivatives and pharmaceutical compositions containing them

Country Status (15)

Country Link
US (1) US6420409B1 (hu)
EP (1) EP1020452A4 (hu)
KR (1) KR20010014166A (hu)
CN (1) CN1135224C (hu)
AR (1) AR016108A1 (hu)
AU (1) AU748541B2 (hu)
BR (1) BR9811273A (hu)
CA (1) CA2294505A1 (hu)
HK (1) HK1028246A1 (hu)
HU (1) HUP0002324A3 (hu)
IL (1) IL133674A0 (hu)
RU (1) RU2243968C2 (hu)
TR (1) TR199903277T2 (hu)
TW (1) TW453999B (hu)
WO (1) WO1999000373A1 (hu)

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CA2295239A1 (en) * 1997-06-27 1999-01-07 Fujisawa Pharmaceutical Co., Ltd. Sulfonamide compounds and medicinal use thereof
WO1999051574A1 (fr) * 1998-04-06 1999-10-14 Fujisawa Pharmaceutical Co., Ltd. Derives d'indole
WO2000028991A1 (fr) * 1998-11-13 2000-05-25 Fujisawa Pharmaceutical Co., Ltd. Remedes contre le syndrome des ovaires polykystiques
WO2000039099A1 (fr) * 1998-12-24 2000-07-06 Fujisawa Pharmaceutical Co., Ltd. Derives de benzimidazole
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
US6525067B1 (en) 1999-11-23 2003-02-25 Pfizer Inc Substituted heterocyclic derivatives
EP1149583A3 (en) * 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
EP1442042A1 (en) 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US20050032854A1 (en) * 2001-12-03 2005-02-10 Kiminori Kawahara Insulin resistance improving agents
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
AU2003223093B2 (en) * 2002-05-03 2010-02-04 Israel Institute For Biological Research Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
AU2003902860A0 (en) * 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
US20050197376A1 (en) * 2004-03-02 2005-09-08 Fujisawa Pharmaceutical Co. Ltd. Concomitant drugs
EP1983992A4 (en) * 2006-01-19 2010-08-18 Abbott Lab 2-IMINO-BENZIMIDAZOLES
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
CN105919987B (zh) * 2009-12-07 2020-04-03 约翰斯霍普金斯大学 N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物及其用途
CA2782248A1 (en) 2009-12-07 2011-06-16 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives
JP5990106B2 (ja) * 2011-01-28 2016-09-07 佐藤製薬株式会社 縮環化合物
JP6456520B2 (ja) 2015-12-11 2019-01-23 帝人ファーマ株式会社 アミノアゾール誘導体
WO2017192728A1 (en) 2016-05-03 2017-11-09 Virginia Commonwealth University Heteroatom -doped porous carbons for clean energy applications and methods for their synthesis

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JPS51133267A (en) 1975-05-08 1976-11-18 Lilly Co Eli Substituted 11sulphonyl benzimidazole
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Also Published As

Publication number Publication date
CN1135224C (zh) 2004-01-21
HUP0002324A3 (en) 2001-07-30
AU7934698A (en) 1999-01-19
RU2243968C2 (ru) 2005-01-10
CA2294505A1 (en) 1999-01-07
HK1028246A1 (en) 2001-02-09
EP1020452A4 (en) 2003-04-02
WO1999000373A1 (fr) 1999-01-07
TW453999B (en) 2001-09-11
US6420409B1 (en) 2002-07-16
WO1999000373A8 (fr) 2000-07-20
AU748541B2 (en) 2002-06-06
AR016108A1 (es) 2001-06-20
BR9811273A (pt) 2000-07-18
CN1268123A (zh) 2000-09-27
KR20010014166A (ko) 2001-02-26
IL133674A0 (en) 2001-04-30
TR199903277T2 (xx) 2000-07-21
EP1020452A1 (en) 2000-07-19

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees