HUP0203487A2 - Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0203487A2
HUP0203487A2 HU0203487A HUP0203487A HUP0203487A2 HU P0203487 A2 HUP0203487 A2 HU P0203487A2 HU 0203487 A HU0203487 A HU 0203487A HU P0203487 A HUP0203487 A HU P0203487A HU P0203487 A2 HUP0203487 A2 HU P0203487A2
Authority
HU
Hungary
Prior art keywords
group
alkoxy group
fluorine
pde4 inhibitors
completely
Prior art date
Application number
HU0203487A
Other languages
English (en)
Inventor
Daniela Bundschuh
Armin Hatzelmann
Hans-Peter Kley
Ivonne Johanna Laan
Jan Geert Sterk
Hendrik Timmermann
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of HUP0203487A2 publication Critical patent/HUP0203487A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

A (I) általános képletű vegyületek[mely képletben R1 és R2 jelentésekülön-külön hidrogénatom vagy együtt további kötést képeznek; Ajelentése -S- (kénatom), -S(O)- (szulfoxid) vagy -S(O)2 (szulfon) ; Arjelentése (a) vagy (b) általános képletű fenilcsoport, ahol R3jelentése halogénatom, 1-4 szénatomos alkoxi-csoport vagy fluorralteljesen vagy túlnyomórészt helyettesített 1-4 szénatomos alkoxi-csoport; R4 jelentése halogénatom, 1-8 szénatomos alkoxi-csoport, 3-7szénatomos cikloalkoxi-csoport, 3-7 szénatomos cikloalkil-metoxi-csoport vagy fluorral teljesen vagy túlnyomórészt helyettesített 1-4szénatomos alkoxi-csoport; R5 jelentése halogénatom, 1-8 szénatomosalkoxi-csoport 3-5 szénatomos cikloalkoxi-csoport, 3-5 szénatomoscikloalkilmetoxi-csoport vagy fluorral teljesen vagy túlnyomórészthelyettesített 1-4 szénatomos alkoxi-csoport; R6 jelentése 1-4szénatomos alkilcsoport; és R7 jelentése hidrogénatom vagy 1-4szénatomos alkil-csoport; vagy R6 és R7 a két szénatommal együtt,amelyekhez kapcsolódnak, adott esetben oxigén- vagy kénatommalmegszakított spiro-kapcsolódású 5-, 6- vagy 7-tagú szénhidrogén-gyűrűtképeznek] hatékony PDE4 inhibitorok. A találmány kiterjed avegyületeket tartalmazó gyógyszerkészítményekre is. Ó
HU0203487A 1999-10-25 2000-10-24 Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények HUP0203487A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99121243 1999-10-25
US20395000P 2000-05-12 2000-05-12
PCT/EP2000/010445 WO2001030777A1 (en) 1999-10-25 2000-10-24 Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors

Publications (1)

Publication Number Publication Date
HUP0203487A2 true HUP0203487A2 (hu) 2003-02-28

Family

ID=26153155

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203487A HUP0203487A2 (hu) 1999-10-25 2000-10-24 Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények

Country Status (20)

Country Link
US (2) US6544993B1 (hu)
EP (1) EP1244654A1 (hu)
JP (1) JP2003512466A (hu)
KR (1) KR20020043238A (hu)
CN (1) CN1146562C (hu)
AU (1) AU781137B2 (hu)
BR (1) BR0014990A (hu)
CA (1) CA2388119A1 (hu)
CZ (1) CZ20021457A3 (hu)
EA (1) EA005856B1 (hu)
HK (1) HK1047276A1 (hu)
HR (1) HRP20020350A2 (hu)
HU (1) HUP0203487A2 (hu)
IL (1) IL148807A0 (hu)
MX (1) MXPA02003581A (hu)
NO (1) NO20021959L (hu)
PL (1) PL354979A1 (hu)
SK (1) SK7232002A3 (hu)
TR (1) TR200201128T2 (hu)
WO (1) WO2001030777A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL148807A0 (en) * 1999-10-25 2002-09-12 Byk Gulden Lomberg Chem Fab Tetrahydrothiopyran derivatives and pharmaceutical compositions containing the same
EA200300836A1 (ru) 2001-02-15 2004-02-26 Алтана Фарма Аг Производные фталазинон-пиперидина в качестве ингибиторов pde4
WO2002085885A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor
CA2445233A1 (en) * 2001-04-25 2002-10-31 Altana Pharma Ag Phthalazinones derivatives useful as pde4/7 inhibitors
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
CA2494643A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-n-oxide-derivatives
CA2494650A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
AU2003255376A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
JP4555684B2 (ja) * 2002-08-10 2010-10-06 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４阻害剤としての、ピロリジンジオンにより置換されたピペリジン−フタラゾン
CA2512819A1 (en) * 2003-01-14 2004-07-29 Altana Pharma Ag Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
EP1716123A1 (en) * 2004-02-04 2006-11-02 Altana Pharma AG Pyridazinone derivatives and their use as pde4 inhibitors
AU2005210042B2 (en) * 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
PL2589599T4 (pl) * 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
EP2651417B1 (en) * 2010-12-16 2016-11-30 Calchan Limited Ask1 inhibiting pyrrolopyrimidine derivatives
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
BR112015023328A2 (pt) 2013-03-13 2017-07-18 Flatley Discovery Lab compostos de piridazinona e métodos para o tratamento de fibrose cística

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9204808D0 (en) * 1992-03-04 1992-04-15 Rhone Poulenc Rorer Ltd Novel compositions of matter
CZ141795A3 (en) 1992-12-02 1995-11-15 Pfizer 4-substituted catechol diethers as such and for treating diseases and pharmaceutical preparations based thereon
DE19533975A1 (de) 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
WO1998031674A1 (en) * 1997-01-15 1998-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinones
PL191236B1 (pl) 1997-12-15 2006-04-28 Altana Pharma Ag Nowe pochodne dihydrobenzofuranowe, lek zawierający nową pochodną dihydrobenzofuranową oraz zastosowanie tych pochodnych do wytwarzania leków do leczenia schorzeń układu oddechowego lub do leczenia dermatologicznego
AU1760399A (en) * 1997-12-15 1999-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh New phthalazinones
US6255303B1 (en) 1998-03-14 2001-07-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone PDE III/IV inhibitors
IL148807A0 (en) * 1999-10-25 2002-09-12 Byk Gulden Lomberg Chem Fab Tetrahydrothiopyran derivatives and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
BR0014990A (pt) 2002-06-18
NO20021959D0 (no) 2002-04-25
EA200200381A1 (ru) 2002-10-31
KR20020043238A (ko) 2002-06-08
EP1244654A1 (en) 2002-10-02
AU1515101A (en) 2001-05-08
EA005856B1 (ru) 2005-06-30
CN1382137A (zh) 2002-11-27
TR200201128T2 (tr) 2002-08-21
HK1047276A1 (zh) 2003-02-14
PL354979A1 (en) 2004-03-22
CN1146562C (zh) 2004-04-21
US6846821B2 (en) 2005-01-25
AU781137B2 (en) 2005-05-05
CZ20021457A3 (cs) 2002-07-17
US6544993B1 (en) 2003-04-08
CA2388119A1 (en) 2001-05-03
IL148807A0 (en) 2002-09-12
WO2001030777A1 (en) 2001-05-03
HRP20020350A2 (en) 2004-02-29
JP2003512466A (ja) 2003-04-02
US20030166655A1 (en) 2003-09-04
MXPA02003581A (es) 2002-10-23
SK7232002A3 (en) 2002-09-10
NO20021959L (no) 2002-05-29

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ALTANA PHARMA AG, DE

Free format text: FORMER OWNER(S): BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH, DE

FD9A Lapse of provisional protection due to non-payment of fees